リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討

The expression of thymidine phosphorylase (dThd Pase) in node-negative human invasive ductal carcinoma tissues was investigated by the immunocytochemical method using anti-thymidine phosphorylase monoclonal antibody.Subjects were 5 recurrent and 30 non-recurrent patients who underwent surgery at the Department of Surgery at Shinshu University Hospital between 1993 and 1996.The median follow-up period was 62.5 months.Positive dThd Pase staining was observed in the five recurrent and four non-recurrent cases. Tumor recurrence was significantly more developed in patients with dThd Pase positive staining than in those with negative staining (p＜0.01).Among the nine dThd Pase positive cases,four patients who were administered doxifluridine (5’-DFUR) or medroxyprogesterone (MPA) did not manifest recurrence. Among the recurrent patients, two were cured by oral administration of 5’-DFUR or MPA. It is suggested that the expression of thymidine phosphorylase in human breast cancer tissues may be a risk factor for tumor recurrence. The prognosis of node-negative and dThd Pase positive breast cancer patients might be improved by hormonal therapy or oral administration of 5’-DFUR.Article信州医学雑誌 49(2): 79-83(2001)journal articl

乳腺Paget病の１例 : 微細石灰化を伴う乳腺症併存例

The patient was a 51-year-old female, who had been treated for eczema of the right nipple. Scrape cytology of the nipple revealed class V, leading to the suspicion of Paget disease.The mammogram showed microcalcification in the right breast tissue.However,neither ultrasonogram nor palpation could detect any tumor there. It was diagnosed as non-invasive ductal carcinoma and modified mastectomy was performed. Breast cancer was localized to the nipple and no malignant cells were revealed in the breast tissue pathologically. This means that the microcalcification was a lesion due to mastopathy, not non-invasive ductal carcinoma.Article信州医学雑誌 47(6): 513-517(1999)journal articl

透析通信システムと電子カルテの同時導入及び連携を経験して

Article長野県透析研究会誌 35(1): 61-63(2012)journal articl