Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report

Surgery can be curative treatment for pelvic locoregional recurrence of endometrial cancer; however, a cure is contingent on complete resection. Here, we report the case of a patient in whom recurrent endometrial tumor remained in the pelvis after resection; long-term control was achieved with postoperative administration of pembrolizumab.The patient had recurrent endometrial cancer of stage IA and was treated with chemotherapy and radiation, but tumor persisted in the pelvic cavity. We therefore attempted total pelvic exenteration, but the tumor was adherent to the pelvic wall and complete resection could not be achieved. However, postoperative administration of pembrolizumab controlled the residual tumor for more than two years without regrowth. We believe that since the resected tumor was MSI-High, the residual tumor responded well to pembrolizumab. It is not known whether cytoreductive surgery contributes to a long-term response to pembrolizumab, but at least in our patient, pembrolizumab appeared to be a very effective drug therapy for MSI-High endometrial cancer that was refractory to chemotherapy and radiotherapy

Smart Inverse Calculation of Anisotropic and Time dependent Parameters of Slate Based on Tunnel Deformation

台灣地質條件因板塊作用劇烈而破碎複雜，在進中央山脈地區進行隧道工程時常遇到板岩地形。其板岩具有異向性與依時性之行為，板岩中因劈理面傾角造成應力分部不均之狀況，而劈理間時常有夾泥之狀況；此外，而觀察其板岩解壓過程之變形趨勢並非單純的彈塑性關係，而是與時間相關之依時性行為。故探討板岩開挖之行為，需同時考慮異向性與依時性之特性，方能較準確模擬其行為。 本研究採用有限差分軟體FLAC執行隧道斷面開挖分析，並以陳勝翔(2016)所撰寫之FLAC外掛UDM材料模組為基礎執行反算。本研究先針對此外掛材料模組進行平行驗證，接著針對陳勝翔以FLAC所建立之隧道開挖模型，進行FISH指令宣告之檢討，修正其初始極限潛變時間階，讓其分析結果更趨近於現地監測結果。 本研究搭配影像操作工具按鍵精靈，發展一套自動化反算參數之邏輯，期望能以此自動化流程，以給定的參數範圍自動的找尋出符合現地監測結果之參數組合。本研究提出之智能運算模式，除可減低人為出錯之機率，並可提高運算之效率(減少本研究案例約20%運算及操作時間)，並減低繁瑣反算時的工作時間以及參數反算時人為出錯之機率。Due to the active tectonic activities, the geological formations in Taiwan areas are highly fractured and complex, and the slate formations are often encountered, in the tunnel engineering near the Central Ridge. The properties of slates include anisotropy and time-dependent behaviors. Due to the existence of cleavages, there is anisotropic stress distribution in the slate rock mass, it is also affected by the mud fillings in the cleavages. In addition, the stress-strain relation of slates is not simple elastic-plastic, but time-dependent. In this study, the finite difference software FLAC was used to perform the tunnel section excavation analysis and the back calculation was carried out based on the FLAC external UDM material module written by Chen (2016). In this study, a preliminary verification by the intrinsic material modules were carried out. Then, the FISH commands were reviewed for the tunnel excavation model established by Chen (2016), especially the command of time step, such that the analysis results can be closer to the monitoring results. This study, couple the monitor tool 'Keyboard Spirit ' a set of automate parameter back calculation logic, in order to automate the back calculation process. For a ranges of parameters, it can automatically find the most suitable set of parameters, it can automatically find the most suitable set of parameters to obtain the numerical result closed to the monitoring result. The result also suggest that the 'SMART' back calculation method not only can reduce the possible errors induced by manual operations, but also can increase that efficiency (reduce the calculation time by about 20% for the cases in this study).目錄 摘要 ii Abstract iii 目錄 iv 圖目錄 viii 表目錄 xii 符號表 xiv 第一章 緒論 1 1.1 前言 1 1.2 研究背景與目的 1 1.3 研究內容 2 1.4 論文架構 3 研究流程圖 4 第二章 文獻回顧 5 2.1 具劈理岩體相關文獻 5 2.2 具依時行為之岩體相關文獻 6 2.3 弱面與依時行為之岩體相關文獻 8 2.4 自動化反算 10 第三章 研究方法 12 3.1 數值分析軟體及介紹 12 3.2 數值理論與模型 13 3.2.1 數值理論基礎 13 3.3 數值模型建立 15 3.3.1 節點設定以及網格劃分 16 3.3.2 元素選用 16 3.3.3 邊界條件 22 3.4 初步分析結果 22 3.4.1 UBI與複合式模型之驗證結果 23 3.4.2 Burger與複合式模型之驗證結果 23 第四章 研究案例 37 4.1 地形地質條件 37 4.2 基本材料參數選用 38 4.3 二維數值模型 38 4.3.1 模型邊界條件、初始應力條件 39 4.3.2 開挖階段以及支撐型式 39 4.3.3 現地與數值之計測 40 4.4 依時行為基本相關研究 41 4.4.1 Maxwell Model 行為 41 4.4.2 Kelvin Model行為 42 4.4.3 Burger Model行為 43 4.5 潛變分析之時間階探討 44 4.5.1 Burger Model 時間階 44 4.5.2 Burger Model相關行為驗證 45 第五章 自動化反算方法驗證 62 5.1 按鍵精靈 62 5.1.1 操作介紹 63 5.1.2 按鍵精靈指令 63 5.2 整體反算流程 64 5.2.1 FLAC操作 65 5.2.2 FLAC結果檔處理 65 5.2.3 資料清除 67 5.2.4 誤差判識 67 5.3 反算方法驗證 69 第六章 案例自動化反算分析結果 84 6.1 分析案例介紹 84 6.2 參數選用 85 6.2.1 UBI參數選用 85 6.2.2 Burger參數選用 86 6.3 反算流程 87 6.3.1 反算區間決定 87 6.3.2 自動化反算 88 6.4 分析結果 89 第七章 結論 106 7.1 結論 106 7.2 建議 108 參考文獻 10

建築裝修材料耐燃性能之品質研究

The good and the bad for incombustibility of interior finish material of building depend on the smoking modulus CA, is concerned with the structural safely of fire control system. Presently, although there is the regulations for examining the incombustibility of interior finish material of building but it lacks the effective evaluation method to judge whether the quality control capability of incombustibility of interior finish material of building attain the requirement or not. Thus, the principle of statistics is used to infer a convenient, effective and reliable evaluation tool to be evaluation standard for quality control of incombustibility of interior finish material of building. This new evaluation procedure is not only useful for the customers to examine and compare the purchase decision but also the best way to improve the production and quality control capability of incombustibility of interior finish material manufacturers.建築裝修材料之耐燃性，攸關整體建築物之消防安全。目前雖有建築裝修材料耐性之規定，但卻鮮有品質管制之有效評估工具。因此本文利用統計推理的方法，發展一套簡便、有效且值得信賴的評估工具，以作為建築防火裝修材料品質管制之評估標準，此法除可有效評估建築防火裝修材料品質外，並可作為研判建築裝修材料製造商之製程與品管能力的指標，進而可作為建商採購建築防火裝修材料之決策及建築裝修材料製造商改進建築防火修材料製造程序與品質納制之依據

知識社群融入電腦數學之教學研究

[[abstract]]本研究主要探討知識社群平台在已提供數位學習的課程中，如何透過知識社群進行課後輔助教學，了解知識社群平台對學生在「電腦數學」課程學習成效之影響因素，並探討學生使用知識社群學習平台的學習態度，希望透過知識社群的學習方式，提供學生多元的課後輔導管道，藉以提升學生的學習成效。本研究使用文獻分析及教學實驗方法，針對修平科技大學日間部資訊管理系四技一年級進行教學實驗，實驗時間為期十週，由知識社群平台所記錄成員使用線上學習情形，再比對平時測驗成績與學生資訊背景問卷、知識社群平台融入數位學習問卷，並進一步統計分析其結果，發現適當的調整知識社群提供的訊息，且與學生積極的互動，及時解答學生的問題，的確對學生的學習有顯著的改善，也相當程度提高了學生的學習意願

2005年第37屆國際化學奧林匹亞實作競賽試題參考題解與評分標準

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2005年第37屆國際化學奧林匹亞理論競賽試題參考題解與評分標準

[[issue]]281

In0.53Ga0.47As/In0.52Al0.48As量子阱二维电子气的零场自旋分裂

用分子束外延(molecular beam epitaxy,MBE)方法在半绝缘InP衬底上生长In0.52Al0.48As/In0.53Ga0.47As/In0.52Al0.48As量子阱样品.在In0.52Al0.48As势垒层中进行元素Si的δ掺杂,元素Si电离的电子转移到量子阱中,在量子阱中形成二维电子气(two-dimensional electron gas,2DEG).对该样品在低温下进行了磁输运测试,得到了2DEG纵向电阻(磁电阻)和横向电阻(Hall电阻)在不同温度下随磁场的变化曲线.观察到磁电阻的Shubnikov-de Haas(SdH)振荡和由零场自旋分裂引起的SdH振荡在低场下的拍频效应.也观察到Hall电阻出现量子Hall效应所特有的Hall平台.对Hall电阻在低场部分的直线拟合获得2DEG的Hall浓度,并根据Hall浓度和零场电导获得2DEG的Hall迁移率.对磁电阻曲线的快速傅立叶变换(fast Fourier trans-form,FFT)分析获得的2DEG浓度与Hall浓度一致.对拍频节点进行分析,获得了2DEG的自旋轨道耦合常数,并由此得到了零场自旋分裂能,自旋弛豫时间,自旋进动长度等实现自旋器件的相关参