不完全川崎病早期诊断的探讨

目的探讨小儿不完全川崎病(Ikd)早期诊断的方法,以提高对该病的临床诊断水平,减少冠状动脉损害的发生。方法对2008年1月-2012年5月在厦门市第三医院儿科住院的21例Ikd患儿的临床表现及辅助检查进行回顾性分析。结果持续发热、川崎病面容、手足硬肿、肛周潮红或脱皮、卡巴红等症状及体征有助于Ikd的早期诊断。炎症指标(ESr及CrP)、WbC及bnP早期增高以及发病10 d内心脏彩超检查发现冠状动脉扩张是早期诊断Ikd可靠的辅助指标。21例Ikd患者中发生冠状动脉扩张10例,占47.6%,与典型kd比较,差异有统计学意义(P<0.05)。结论由于Ikd病例中冠状动脉病变发生率较高,对持续发热5天以上的婴幼儿,当出现川崎病面容、手足硬肿、肛周潮红或脱皮及卡巴红等表现中的2~3项时要引起重视,尽早做相应的辅助检查及心脏冠状动脉检测,尽早明确诊断,给予早期治疗,以避免冠状动脉损害的发生

F-box proteins and their functions

[中文文摘]F-box蛋白是一类广泛存在于真核生物中,含有F-box结构域的蛋白家族,在泛素-蛋白酶体途径(ubiquitin-protcasomc pathway,UPP)中因特异识别底物蛋白而参与细胞周期调控、转录调控、细胞凋亡、细胞信号转导等生命活动。另外,F-box蛋白还通过其他作用方式参与了体内众多生化过程。本文综述了F-box蛋白的结构和作用途径,以及该蛋白参与的多种生理功能,展示了F-box蛋白家族在生命活动中具有广泛而重要的作用,并指出了F-box蛋白将为阐明疾病发生机制提供新的线索,可望成为疾病治疗中药物作用的靶向位点。[英文文摘]F-box proteins are an expanding family of eukaryotic proteins characterized by an"F-box"motif.They are in charge of substrate specificity in the ubiquitin-proteasome pathway and therefore play a pivotal role in many physiological activities such as cell-cycle progression,transcriptional regulation,programmed cell death and cell signal transduction.In addition,F-box proteins participate in many other biochemical processes through different ways.In this review we focus on the structure and function of F-box proteins and reveal that this protein family has an important role in life. Furthermore,we indicate that F-box proteins are attractive candidates in the disease therapy and drug interaction.福建省青年科技人才创新项目(2006F3128

一种开放海域沉积物污染的修复方法

本发明涉及利用微生物进行水环境治理领域，具体地说，本发明涉及一种开放海域或较深淡水水域、河口等沉积物污染的修复方法。将菌株经沸石负载并絮凝剂包覆，而后将包覆后菌剂投放至待处理水域，进而修复水域内沉积物石油及有机污染物。本发明方法主要针对水深在2?50米的海水/淡水水域，对沉积物的石油污染及其他有机污染有很好的修复效果，该方法系统完整且操作方法简单、沉积物修复效果显著、无二次污染且海上施工安全性较高，特别适合特殊功能性海域，如石油开采区、水产养殖区等，能够指导海洋沉积物污染修复工程的实施

Graphene-Based Fibers: A Review

Motivated by their unique structure and excellent properties, significant progress has been made in recent years in the development of graphene-based fibers (GBFs). Potential applications of GBFs can be found, for instance, in conducting wires, energy storage and conversion devices, actuators, field emitters, solid-phase microextraction, springs, and catalysis. In contrast to graphene-based aerogels (GBAs) and membranes (GBMs), GBFs demonstrate remarkable mechanical and electrical properties and can be bent, knotted, or woven into flexible electronic textiles. In this review, the state-of-the-art of GBFs is summarized, focusing on their synthesis, performance, and applications. Future directions of GBF research are also proposed

Reversible Addition-fragmentation Chain Transfer Polymerization of Styrene and Synthesis of Derived Block Copolymer

通信作者：ｙｓｚｏｕ＠ｘｍｕ．ｅｄｕ．ｃｎ[中文文摘]用三硫代碳酸双(α,α′-二甲基-α″-乙酸)酯作为可逆加成-断裂链转移(RAFT)聚合的链转移剂,制备了一系列具有不同相对分子质量,且相对分子质量分布较窄的聚苯乙烯均聚物.以得到的末端冠有链转移剂活性基团的聚苯乙烯作为大分子链转移剂,与丙烯酸乙酯(EA),丙烯酸丁酯(BA),甲基丙烯酸乙酯(EMA)和甲基丙烯酸丁酯(BMA)4种单体分别进行嵌段聚合反应;通过一步投料,合成了聚苯乙烯-聚(甲基)丙烯酸酯类的两亲性三嵌段共聚物.使用凝胶渗透色谱(GPC)、1 H-NMR对共聚物进行表征. [英文文摘]Ｐｏｌｙｓｔｙｒｅｎｅ　ｗａｓ　 ｐｏｌｙｍｅｒｉｚｅｄ　ｔｈｒｏｕｇｈ　ｕｓｉｎｇ　ｔｈｅ　Ｓ，Ｓ′－ｂｉｓ（Ｒ，Ｒ′－ｄｉｍｅｔｈｙｌａｃｅｔｉｃ　ａｃｉｄ）ｔｒｉｔｈｉｏｃａｒｂｏｎａｔｅ　 ａｓ　ｒｅｖｅｒｓｉｂｌｅ　ａｄｄｉｔｉｏｎｆｒａｇｍｅｎｔａｔｉｏｎ 　ｃｈａｉｎ　ｔｒａｎｓｆｅｒ（ＲＡＦＴ）ａｇｅｎｔｓ．Ｔｈｅ　ｓｙｎｔｈｅｓｉｚｅｄ　ｐｏｌｙｓｔｙｒｅｎｅ　ｈａｄ　ｖａｒｉｏｕｓ　ｃｏｎｔｒｏｌｌｅｄ　 ｍｏｌｅｃｕｌａｒ　ｗｅｉｇｈｔ　ａｎｄ　ｎａｒｒｏｗ　ｍｏｌｅｃｕｌａｒ 　ｗｅｉｇｈｔ　ｄｉｓｔｒｉｂｕｔｉｏｎ．Ａ　ｓｅｒｉｅｓ　ｏｆ　ｄｉｆｆｅｒｅｎｔ　ａｍｐｈｉｐｈｉｌｉｃ　ｔｒｉｂｌｏｃｋ　ｃｏｐｏｌｙｍｅｒｓ　ｗｅｒｅ　ｒｅｓｐｅｃｔｉｖｅｌｙ　ｓｙｎｔｈｅｓｉｚｅｄ　ｗｉｔｈ　ｔｈｅ　ａｄｄｉｔｉｏｎ　ｏｆ ｅｔｈｙｌ　ａｃｒｙｌａｔｅ，ｂｕｔｙｌ　ａｃｒｙｌａｔｅ，ｅｔｈｙｌ　ｍｅｔｈａｃｒｙｌａｔｅ　ａｎｄ　ｂｕｔｙｌ　ｍｅｔｈａｃｒｙｌａｔｅ．Ｄｕｒｉｎｇ　ｔｈｅ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｒｉｂｌｏｃｋ　ｃｏｐｏｌｙｍｅｒｓ，ｔｈｅ　ａｂｏｖｅ　ｏｂｔａｉｎｅｄ　ｐｏｌｙｓｔｙｒｅｎｅ　ｗａｓ　ｕｓｅｄ　ａｓ　ｍａｃｒｏｍｏｌｅｃｕｌａｒ　ＲＡＦＴ　ａｇｅｎｔ．Ｔｈｅ　ｄｅｒｉｖｅｄ　ｐｏｌｙ（ｍｅｔｈｙ）ａｃｒｙｌａｔｅ　ｂｌｏｃｋ　ｐｏｌｙｓｔｙｒｅｎｅ　ｂｌｏｃｋ　ｐｏｌｙ（ｍｅｔｈｙ） ａｃｒｙｌａｔｅ　ｃｏｐｏｌｙｍｅｒｓ ｗｅｒｅ　ｃｈａｒａｃｔｅｒｉｚｅｄ　ｂｙ　ＧＰＣ　ａｎｄ　１　Ｈ－ＮＭＲ

The Effect of Cross-Linking Agent on the Preparation of the Thermally Expandable Microspheres

以丙烯腈为主要单体,以氢氧化镁为无机分散剂,采用常压聚合法,制备了膨胀倍率达到20-30倍的可膨胀小球。系统研究了二丙二醇二丙烯酸酯(dPgdA)、三缩丙二醇二丙烯酸酯(TPgdA)、新戊二醇二丙烯酸酯(nPgdA)、三羟甲基丙烷三丙烯酸酯(TMPTA)和二乙烯基苯(dVb)等5种交联单体对可膨胀小球制备的影响。通过扫描电子显微镜、热重分析、交联密度测定等手段研究了可膨胀小球的形貌、粒径、发泡剂的含量、交联密度、发泡倍率。确定dPgdA为最佳的交联剂种类,用量为1.7%。采用dPgdA作为交联剂的小球既具有较完好的球状形貌,又有较小的粒径,较高的发泡剂含量和较高的交联度,膨胀倍率可达30倍。The thermally expandable microspheres,using acrylonitrile as the main monomer and magnesium hydroxide as the inorganic dispersant,were prepared with atmospheric suspension polymerization.This study systematically researched the effect of cross-linking agent such as dipropylene glycol diacrylate(DPGDA),tripropylene glycol diacrylate(TPGDA),trimethylolpropane trimethacrylate(TMPTA), noe ponlyl glycol di acrylate(NPGDA)and divinylbenzene(DVB)on the preparation of the thermally expandable microspheres.By using scanning electron microscope,thermogravimetric analysis and determination of cross-linking density,the morphology,particle size,foaming agent content,cross-linking density and foaming ratio of thermally expandable microspheres were studied.As a result,DPGDA is found to be the most suitable cross-linking agent because the microspheres prepared with it have the perfect surface morphology,small particle size,high blowing agent content and high cross-linking degree and the dosage is 1.7%