Research of Super-resolution Reconstruction Based on Sparse Representation with Multi Component Dictionary

基于稀疏表示的超分辨率重建算法方法是近年来超分辨率图像重建研究中的热点。在超分辨率图像重建中，需要从现有的低分辨率图像的低频信息中恢复高频信息，因此如何构建高频部分的字典是基于稀疏表示的超分辨率重建的关键。 任意一幅图像，通过形态学成分分析分解成纹理和平滑两部分，且其间相互独立，对纹理部分和平滑部分分别进行学习训练构建过完备字典，用于超分辨率重建。 本文首先将用于训练的高分辨率图像集分离出平滑和纹理两子图，对这两子图分别按照一定的比例（本文采用1/3）进行降采样，然后再采用某种插值方法（本文采用Bicubic插值），将降采样的纹理子图和平滑子图扩大为与原图像同等大小，并将原子图与插值的子图...Super-resolution reconstruction based on sparse representation has been paid more attention in recent years, which need restore the high-frequency information from the low frequency data existing in the low-resolution image. Therefore, it is the key to construct the dictionary containing the high frequency part for super-resolution reconstruction. Every image can be decomposed into texture and ca...学位：工程硕士院系专业：信息科学与技术学院_计算机技术学号：2302011115307

基于微服务的高校信息化系统研究和实现

高校信息化系统基于传统三层BS(Browser/Server,浏览器/服务器模式)架构设计,随着信息化系统的增加,运维难度加大,数据共享变得困难。文章分析了高校信息化系统存在的问题,认为在教育信息化2.0的背景下,高校信息化建设应当尽快进入基于API(Application Programming Interface,应用程序接口)的微服务时代。介绍了开源API网关的选择和在高校使用场景下的配置细节,给出了API开发者应当遵循的最佳实践,并且对开源API网关缺失的统计和监控功能进行了补充。通过基于微服务的开发理念,使用自动化部署手段结合开源软件和少量编程搭建API网关,编写的示例应用验证了通过解决微服务全生命周期管理问题,高校的信息化系统开发、运维将更加透明和高效,数据共享将更为安全。中国高等教育学会2016年度教育信息化专项课题(2016XXZD06

Medication rules in the treatment of digestive system neoplasms of WANG Yan-hui

目的:基于中医传承辅助平台软件,分析王彦晖教授治疗消化系统肿瘤的用药规律。方法:收集并筛选王教授于厦门燕来福国医堂治疗消化系统肿瘤病案,录入中医; 传承辅助平台软件,运用软件集成的数据分析方法,分析王教授治疗消化系统肿瘤的用药规律。结果:筛选出治疗消化系统肿瘤处方672首,分析得出其治疗消化; 系统肿瘤常用药物包括茯苓、陈皮、姜半夏、莪术、三棱、党参、白术、龙骨、牡蛎等,并演化出4首治疗消化系统肿瘤的新处方。结论:王教授治疗消化系统肿瘤; 以益气健脾、理气化痰、祛瘀散结为基本大法,扶正祛邪并重,同时根据闽南地区脾虚湿盛的致病特点重视健脾袪湿治法,并兼顾安神、止痛等治法以综合调理患者; 的机体状态。Objective: To study the medication rules in the treatment of digestive; system neoplasms of professor WANG Yan-hui using the traditional Chinese; medicine inheritance support system software (TCMISS, V2.5). Methods:; The prescriptions used by professor WANG Yan-hui in treating digestive; system neoplasms at the Yan-Lai-Fu Chinese Medicine Clinic were; collected as input data into TCMISS and were analyzed by software; integration method. Results: Totally of 672 prescriptions were selected; according to the collection standard in digestive system neoplasms; treatment. It was found that the most frequently used Chinese medicine; in these prescriptions including Tuckahoe, Pericarpium Citri; Reticulatae, Pinellia Tuber, Rhioxma Curcumae Aeruginosae, Rhizome of; Common Burreed, Root of Pilose Asiabell, Rhizome of Largehead; Atractylodes, Fossilizid, Oyster Shell, and so on. Furthermore, four new; prescriptions for treating digestive system neoplasms were created.; Conclusion: The core rules of professor WANG Yan-hui in treating; digestive system neoplasms were invigorating spleen and replenishing qi,; regulating qi-flowing for eliminating phlegm and dispelling stasis and; resolving hard mass, which means that strengthening vital qi and; eliminating pathogenic factor are equally emphasized in his; prescriptions. Besides, taking into consideration the climate; characteristics of the southern Fujian, professor WANG Yan-hui attaches; importance to invigorating spleen for eliminating dampness, combining; with tranquillization and relieving pain to treating patients; comprehensively.国家自然科学基金项目; 教育部新世纪优秀人才支持计划; 福建省自然科学基金项目; 厦门市科技计划项

Construction and identification of interference plasmid targeting on TNFAIP8

目的:构建并筛选出干扰效率最佳的TnfAIP8-SHrnA-P SIrEn-rETrO Q干扰质粒。方法:通过生物软件选择3个TnfAIP8基因干扰位点,构建干扰质粒并测序验证,将干扰质粒及对照质粒分别转染至A549细胞,通过rT-PCr、WESTErn blOT检测干扰效率。结果:经rT-PCr和WESTErn-blOT证实TnfAIP8-SHrnA-P SIrEn-rETrO Q干扰质粒能有效干扰并抑制细胞内TnfAIP8基因的表达,通过流式检测发现降低TnVAIP8表达可以提高细胞对A dr5SC fV诱导凋亡的敏感性。结论:成功构建和设计了对TnfAIP8基因具有显著干扰效率的干扰质粒,为进一步研究TnfAIP8基因的功能奠定了基础。Objective: To construct and screen the high efficiency interference plasmid of TFAIP8-shRNA-p SIRENRetro Q.Methods: Selected and synthesized three Target Sequence of TNFAIP8 shRNA1,TNFAIP8 shRNA2,TNFAIP8 shRNA3,and construct the TNFAIP8 interference plasmid.Transfection TNFAIP8-shRNA-p SIREN-Retro Q interference plasmid to A549 cells.Filter out the highest interference efficiency plasmid by detecting the mRNA and protein levels using RT-PCR and Western blot methods.Results: We successfully design and built three TNFAIP8-shRNA-p SIREN-Retro Q interference plasmids,and screen out the highest efficiency interference plasmid.Conclusion: Three interference plasmids targeting the TNFAIP8 gene have been constructed successfully and provide a useful tool for studying the function of TNFAIP8.国家自然科学基金项目(81272720); 福建省卫计委医学创新课题(2014-CXB-43); 厦门市科技计划项目(3502Z2083008)资

缺血缺氧环境下葡萄糖转运蛋白1对人脐静脉内皮细胞功能的调控作用

目的本研究旨在探讨葡萄糖转运蛋白1（GLUT1）在缺血缺氧环境下对人类脐静脉内皮细胞（HUVECs）增殖、迁移、粘附和血管形成的影响及其调控作用。方法通过体外实验，将HUVECs置于模拟缺血缺氧的环境中（1%O2，5%CO2，94%N2），对比分析了常氧与缺血缺氧条件下HUVECs的生物学特性，通过检测细胞活性、细胞增殖能力以及利用Western blot技术比较缺血缺氧条件下GLUT1、HIF-1α、VEGFA蛋白的表达变化。进一步采用质粒转染技术过表达GLUT1，并通过划痕实验、细胞粘附实验和管状结构形成实验来评估HUVECs的增殖、迁移、粘附和血管形成能力，透射电镜观察线粒体形态变化，Seahorse代谢分析仪检测氧消耗率（OCR）以评估线粒体功能。结果与常氧条件相比，缺血缺氧环境显著抑制了HUVECs的增殖、细胞活性、迁移和粘附能力，并损害了其血管形成能力。同时，GLUT1，HIF-1α及VEGFA蛋白的表达均显著降低。而在上调GLUT1表达的情况下，HUVECs的迁移、粘附和血管形成能力得到明显改善，同时HIF-1α和VEGFA的蛋白表达量也增加。透射电镜显示，缺血缺氧导致线粒体肿胀和基质损伤，而GLUT1过表达显著缓解线粒体形态异常。OCR结果表明，GLUT1过表达可增强缺血缺氧环境下内皮细胞氧化磷酸化从而改善能量代谢。这些结果提示GLUT1可能通过调节葡萄糖代谢和能量供应，影响HUVECs的功能和血管生成能力。结论本研究揭示了GLUT1在缺血缺氧环境下对HUVECs功能的重要调控作用，这种调控可能通过调节细胞能量代谢和信号传导途径，进而影响细胞增殖、迁移、粘附和血管形成。这些发现为理解GLUT1在心血管疾病中的作用提供了新的视角，并可能为开发新的治疗策略提供潜在的靶点

Study on removal boron from solargrade silicon with hydrometallurgy

湿法提纯作为冶金法制备太阳能级硅的前处理工序,可以去除大部分金属和硼杂质。研究了以氢氟酸-硫酸混合酸为浸出剂,有机溶剂甲醇作为后处理剂,去除硅粉中硼杂质的方法。采用电感耦合等离子体发射光谱仪(ICP)等对产品进行表征。酸浸过程优化工艺条件:硫酸质量分数为55%,氢氟酸质量分数为7%,酸浸温度为70℃、酸浸时间为4 H、液固质量比为8∶1。酸浸后可使硅粉中的硼杂质质量分数由6.893x10-6降至3.867x10-6,去除率为41.9%。在酸浸基础上采用有机溶剂甲醇作为后处理剂,杂质硼质量分数降至3.84x10-6,去除率为44.29%。从硼酸浸后形成的产物入手探索提高硼去除率的方法,实验验证了该方法的可行性,为研究湿法冶金预处理太阳能级硅提供了新的参考。As a pretreatment unit for preparing solargrade silicon(SG-Si) by metallurgic method,wet purification could remove most metallic impurities and nonmetallic impurities,such as boron.Experiment researched a new method to remove boron from SG-Si with mixed hydrofluoric acid-sulfuric acid as leaching agent and with organic solvent methanol as posttreatment agent.Samples were characterized by ICP and other analysis methods.When SG-Si powder had been leached at optimized conditions as follows:mass fraction of sulfuric acid was 55%,mass fraction of hydrofluoric acid was 7%,reaction temperature was 70 ℃,reaction time was 4 h,and liquid-solid mass ratio 8∶1,it was found that mass fraction of impurity boron in SG-Si was reduced to 3.867×10-6 from 6.893×10-6 and the removal rate was 41.9% after acid leaching;on the basis of the former procedure,mass fraction of impurity boron was reduced to 3.84×10-6 and the removal rate was 44.29% when treated with organic solvent.Experiment proved the feasibility of the method and provided a new reference for researching on the pretreatment of SG-Si by hydrometallurgy

Development and fluidized simulation of semi-continuous pilot reactor for carbon nanotubes preparation

第一作者：朱丽（1980—），女，硕士研究生，从事化工过程开发与设计研究。E-mail:[email protected]。联系人：汤培平，教授。E-mail:[email protected]。[中文文摘]在间歇过程的碳纳米管制备实验基础上结合经验公式,开发设计了制备碳纳米管的半连续中试流化床反应器,结果表明:催化剂100 g、反应温度650℃时,甲烷平均转化率23.2%,碳纳米管产率为177.5 g/h,操作周期为间歇反应器的1/3,反应器可较好地实现碳纳米管制备功能。用计算流体力学方法对此反应器内的气固两相流化行为进行数值模拟,得到在工况条件下,最佳的催化剂用量为100 g、操作气速为0.15 m/s等工艺参数。[英文文摘]Semi-continuous pilot test fluidized bed reactor for carbon nanotubes preparation was designed and fabricated,base on experiments of batch fluidized bed reactor and repeated calculations.When reaction temperature is 650 ℃,reaction time is 4 h,velocity of CH4,H2,N2 are 0.1m/s,0.008 m/s,0.016 m/s,the yield of carbon nanotubes is 177.5 g/h,conversion of CH4 is 23.2%,production cycle is shortened by 2/3.The fluidization behavior of gas-solid fluidization process was calculated by using the computational fluid dynamics(CFD) package Fluent6.1.And the optimal condition for carbon nanotubes is that the velocity of CH4 is 0.1m/s,and catalyst is 100g

Effect of Different Concentrations of NaCl and Light Intensities on β-carotene Content in Dunalie

以2种杜氏藻即巴氏杜氏藻和盐生杜氏藻为实验材料,在不同NaCl胁迫和光照(紫外线和高光照强度)进行培养的结果表明,细胞生长的最适盐度是2.0mol·L-1,高产β-胡萝卜素的最适盐度是3.5mol·L-1;紫外线下诱导的藻株环境适应能力较强,β-胡萝卜素含量较高;高光照强度(1080μmol·m-2·s-1)下诱导的杜氏藻β-胡萝卜素含量高;二步法培养的β-胡萝卜素含量比正常培养的提高2倍以上。福建省科技计划重点项目(2003N053

苯胺嘧啶衍生物X-9通过下调整合素β1表达抑制肝细胞癌迁移侵袭

整合素在许多肿瘤细胞中高表达，并且参与肿瘤细胞的侵袭转移。在肝细胞癌中，整合素β1被报导高表达，并促进肿瘤细胞的侵袭。目前，对于整合素的表达调控癌细胞机制以及干预其表达进而抑制肿瘤细胞转移的研究较少。本研究探讨利用小分子化合物抑制整合素表达来抑制肿瘤细胞迁移和侵袭的可能。首先，对临床肝癌细胞患者癌组织和癌旁组织中的整合素β1的表达进行检测，发现其在癌组织中的表达显著高于癌旁组织（P<0.05）。对TCGA肿瘤数据库的生物信息学分析结果同样显示，整合素β1的高表达与肝癌的分期（P=0.019）和预后（P=0.013）相关。通过筛选发现，苯胺嘧啶衍生物X-9可以抑制肝癌细胞中整合素β1的mRNA和蛋白质的表达（P<0.01）。细胞划痕愈合实验和细胞穿孔结果显示，苯胺嘧啶衍生物X-9能够抑制肝癌细胞的迁移和侵袭（P<0.01）。进一步的研究证实，在肝癌细胞中外源表达整合素β1可以逆转X-9对肝癌细胞迁移和侵袭的抑制；而在敲除整合素β1的细胞中，X-9对细胞的迁移和侵袭的抑制被消除。因此，鉴定出苯胺嘧啶衍生物X-9可以通过下调整合素β1表达，进而抑制肝癌细胞的迁移和侵袭。福建省自然科学基金（No.2016J05087,No.2017J01201）;;福建省卫计委医疗创新项目（No.2015-CXB-15