塑料闪烁体β射线望远镜的能量刻度

建立了一台塑料闪烁体β射线望远镜并进行了能量刻度.利用一组端点能量从0.7MeV到6.1MeV的β~+发射体作为参考源,线性能量刻度的误差仅35keV

一台塑料闪烁体β望远镜的能量刻度

一套△E-E塑料闪烁体β望远镜系统,用一组β~+、β~-及单能电子源~(297)Bi进行了线性能量刻度。对β谱用两种不同的方法进行了处理;对原始数据经过有限能量分辨修正后进行费米-库里标绘和对原始数据开方后直接进行线性拟会。结果表明:后一种方法可以很快地对端点能量绘出粗略的估计,前一种可以用来较好地确定端点能量,所给出的能量刻度的不确定性大约为35keV,而且,对塑料闪烁体探测器,β~+与β~-的响应函数没有很大差别

157W准连续AlGaAs/GaAs激光二极管线列阵

通过优化设计量子阱结构和列阵结构，减小腔面光功率密度，避免器件腔面灾变损伤，得到1cm AlGaAs/GaAs激光二极管线列阵，在热沉温度21℃，脉冲宽度200μs，重复频率100Hz时，输出峰值功率达157W

Hairpin Locked Nucleic Acids Probe Based Electrochemical Biosensor for Detection of BCR/ABL Fusion Gene

基于慢性粒细胞白血病中BCR/ABL融合基因的碱基序列，设计了一种新型发夹结构锁核酸(locked nucleic acids, LNA)探针，把LNA探针通过Au-s键固定在金电极表面构建了特异的生物传感器.LNA探针与目标链DNA杂交，以自行合成的苯甲酸二聚铜配合物([Cu2(C7H5O2)4(C2H6O)2], 简称[Cu(R)2]2+)为杂交指示剂，应用差示脉冲伏安法进行检测，表现出良好的响应信号.该新型锁核酸传感器能较好的区分完全互补链DNA、单碱基错配链DNA.对互补链DNA检测的线性范围为1.0×10-8～1.0×10-6 mol•L-1，检出限为2.0×10-9 mol•L-1.In this article, a new kind of structure hairpin LNA probe was designed to detect BCR/ABL fusion gene in Chronic Myelocytic Leukemia. The LNA probe was immobilized on the gold electrode(AuE) through sulfur–Au interaction to construct specific electrochemical biosensor. The electrochemical response of the sensor to hybridization of the LNA probe with the target DNA was studied using [Cu(R)2]2+ as an electrochemical indicator. The optimal condition was discussed. The experimental results indicated that in pH 7.4 PBS buffer solution, this new method has excellent specificity for single base mismatch and complementary after hybridization. The relationship between the increased oxidation peak current of [Cu(R)2]2+ and the concentration of complementary strand was linear in the range of 1.0×10-8~1.0×10-6 mol/L. The detection limit was 2.0×10-9 mol/L.国家自然科学基金项目(20675015)，国家863计划(No. 2008AA02Z433)，福建省自然科学基金(No.2010J06011, 2010J01032)，福建省教育厅（No.JA10155），福建省高校产学研科技重点项目(2010Y4003)作者联系地址：福建医科大学药学院，福建 福州 350004Author's Address: College of Pharmacy, Fujian Medical University, Fuzhou 350004,China通讯作者E-mail：[email protected]