Language Prompt for Autonomous Driving

A new trend in the computer vision community is to capture objects of interest following flexible human command represented by a natural language prompt. However, the progress of using language prompts in driving scenarios is stuck in a bottleneck due to the scarcity of paired prompt-instance data. To address this challenge, we propose the first object-centric language prompt set for driving scenes within 3D, multi-view, and multi-frame space, named NuPrompt. It expands Nuscenes dataset by constructing a total of 35,367 language descriptions, each referring to an average of 5.3 object tracks. Based on the object-text pairs from the new benchmark, we formulate a new prompt-based driving task, \ie, employing a language prompt to predict the described object trajectory across views and frames. Furthermore, we provide a simple end-to-end baseline model based on Transformer, named PromptTrack. Experiments show that our PromptTrack achieves impressive performance on NuPrompt. We hope this work can provide more new insights for the autonomous driving community. Dataset and Code will be made public at \href{https://github.com/wudongming97/Prompt4Driving}{https://github.com/wudongming97/Prompt4Driving}

FeSiO4H2 stabilized at subducting slab conditions: A geologically viable water carrier into the Earth's lower mantle

Hydrous minerals hold the key to unlocking the enduring mystery of the water cycle deep inside the Earth. Tremendous efforts have been devoted to identifying geologically viable minerals meeting stringent pressure-temperature-density stability requirements for descent into deep Earth, and such pursuits remain active. Here, we identify two hydrous iron silicates, α- and β−FeSiO4H2, formed by a reaction of Earth-abundant FeSiO3 and H2O and stabilized at the pressure-temperature conditions in cold subducting slabs. These phases have a sufficiently high density for a stable descent into the Earth's lower mantle, and then decompose to release water after reaching equilibrium with the mantle geotherm. Moreover, Mg(Fe)SiO4H2 solutions are found to be more stable than the pure substances and can serve as effective carriers to transport substantial amounts of water to lower-mantle regions via the cold subduction zones. These findings establish a viable and robust material basis for the deep-Earth water cycle, with major implications for elucidation of many prominent geological processes

Prediction of fully metallic {\sigma}-bonded boron framework induced high superconductivity above 100 K in thermodynamically stable Sr2B5 at 40 GPa

Metal borides have been considered as potential high-temperature superconductors since the discovery of record-holding 39 K superconductivity in bulk MgB2. In this work, we identified a superconducting yet thermodynamically stable F43m Sr2B5 at 40 GPa with a unique covalent sp3-hybridized boron framework through extensive first-principles structure searches. Remarkably, solving the anisotropic Migdal-Eliashberg equations resulted in a high superconducting critical temperature (Tc) around 100 K, exceeding the boiling point (77 K) of liquid nitrogen. Our in-depth analysis revealed that the high-temperature superconductivity mainly originates from the strong coupling between the metalized {\sigma}-bonded electronic bands and E phonon modes of boron atoms. Moreover, anharmonic phonon simulations suggest that F43m Sr2B5 might be recovered to ambient pressure. Our current findings provide a prototype structure with a full {\sigma}-bonded boron framework for the design of high-Tc superconducting borides that may expand to a broader variety of lightweight compounds.Comment: 5 page

Role of natural products in tumor therapy from basic research and clinical perspectives

Cancer is the leading cause of morbidity and mortality worldwide and is an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally and increasing numbers of natural products are approved for clinical studies involving cancer in recent years. To gain more insight into natural products that have undergone clinical trials for cancer treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website was searched for relevant clinical trials and natural product information up to December 2022. The search terms included different types of cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric and haematologic. Then, PubMed and Web of Science were searched for relevant articles up to February 2024. Hence, we listed existing clinical trials about natural products used in the treatment of cancers and discussed the preclinical and clinical studies of some promising natural products and their targets, indications, and underlying mechanisms of action. Our intent was to provide basic information to readers who are interested or majoring in natural products and obtain a deeper understanding of the progress and actions of natural product mechanisms of action

Divergent coupling mechanism of precipitation on plant community multifunction across alpine grassland on the Tibetan Plateau

IntroductionIt is essential to understand plant adaptive strategies on plant stoichiometric traits at the species level rather than at the community level under various environmental conditions across the Tibetan Plateau (TP).MethodsHere, plant community function and edaphic and meteorological factors were collected at 111 sites along an extensive water–heat gradient during the peak growing season in 2015. Community-weighted mean trait (CWM) was introduced to illuminating dynamics of the functional trait at the community level.ResultsOur results indicated that plant functional traits, including CWM-leaf total carbon (CWM_LTC), CWM-leaf total nitrogen (CWM_LTN), and CWM-leaf total phosphorus (CWM_LTP), showed similar and comparatively marked increases from alpine meadow (AM) to alpine steppe (AS). Moreover, since the tightly coordinated variation among each plant functional trait of AM was higher than that of AS, a more stable coupling mechanism of these plant functional traits could be observed in AM under a long-term evolutionary habit. Specifically, there was higher annual mean precipitation (AMP) in AM than that in AS significantly (P < 0.01), and AMP was significantly correlated with soil moisture and soil total phosphorus in AM. Generally, our findings suggest that precipitation determines divergent coupling plant community function in both AS and AM

México: informe de la coyuntura económica: primer trimestre de 1999

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IPC02-27155 DEVELOPMENT OF LARGE DIAMETER X70 HIGH TOUGHNESS HSAW LINEPIPE FOR GAS TRANSMMISION

ABSTRACT X70 large diameter linepipe with helical seam SAW were developed, with1016mm OD and 14.6mm WT. Acicular ferrite type linepipe steel is adopted for the base material, which was found having high toughness and low yield strength loss after pipe forming. The very stringent requirements for toughness, i.e. 190J/140J for average/minimum for pipe body and 120J/90J for average/minimum for weld and HAZ were meet successfully. The yield strength loss due to Bauschinger effect was found lower than 20 MPa, which benefited

Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood

Introduction: Agarwood is a traditional aromatic southern medicine. It has a long history of being used in traditional Chinese aromatherapy to treat insomnia, anxiety and depression. Due to the scarcity of wild resources, people have planted trees successfully and begun to explore various agarwood-inducing techniques. This study comparative analysis of volatile metabolites in agarwood produced by various inducing techniques and its potential sleep-promoting, anti-anxiety and anti-depressant network pharmacological activities. Methods: A total of 23 batches of two types of agarwood were collected, one of which was produced by artificial techniques, including 6 batches of TongTi (TT) agarwood produced by “Agar-Wit” and 6 batches of HuoLao (HL) agarwood produced by “burning, chisel and drilling”, while the other was collected from the wild, including 6 batches of BanTou (BT) agarwood with trunks broken due to natural or man-made factors and 5 batches of ChongLou (CL) agarwood with trunks damaged by moth worms. The study employed metabolomics combined with network analysis to compare the differences in volatile metabolites of agarwood produced by four commonly used inducing techniques, and explored their potential roles and possible action targets in promoting sleep, reducing anxiety, and alleviating depression. Results: A total of 147 volatile metabolites were detected in agarwood samples, mainly including small aromatic hydrocarbons, sesquiterpenes and 2-(2-phenylethyl) chromone and their pyrolysis products. The results showed composition of metabolites was minimally influenced by the agarwood induction method. However, their concentrations exhibited significant variations, with 17 metabolites showing major differences. The two most distinct metabolites were 6-methoxy-2-(2-phenylethyl) chromone and 6,7-dimethoxy-2-(2-phenylethyl) chromone. Among the volatile metabolites, 142 showed promising potential in treating insomnia, anxiety, and depression, implicating various biological and signaling pathways, predominantly ALB and TNF targets. The top three active metabolites identified were 2-(2-phenylethyl) chromone, 1,5-diphenylpent-1-en-3-one, and 6-methoxy-2-[2-(4'-methoxyphenyl) ethyl] chromone, with their relative content in the four types of agarwood being TT>HL>CL>BT. Conclusion: The differences in the content of 2-(2-phenylethyl) chromones suggest that they may be responsible for the varying therapeutic activities observed in different types of agarwood aromatherapy. This study offers theoretical support for the selection of agarwood in aromatherapy practices

Contamination levels and dietary exposure risk assessment of indicator polychlorinated biphenyls in pork in some regions of China

ObjectiveTo investigate the contamination levels of indicator polychlorinated biphenyls （PCBs） in pork in China and the dietary exposure and risks of Chinese residents.MethodsThe concentration of seven indicator PCBs （PCB 28， PCB 52， PCB 101， PCB 118， PCB 138， PCB 153， and PCB 180） in 203 pork samples from 13 provinces （autonomous regions， centrally administered municipality） in China in 2020 as monitoring sites were analyzed by combined isotope dilution-gas chromatography-high resolution mass spectrometry. The health risk of the population exposure of indicator PCBs through pork was assessed in conjunction with date on pork consumption in each province.ResultsThe mean concentrations of the seven indicator PCBs （∑7PCBs） in pork ranged from 0.053 （Guangxi） to 0.826 ng/g fat （Zhejiang）， and P95 concentrations ranged from 0.091 （Guangxi） to 2.702 ng/g fat （Zhejiang）. PCB 28 and PCB 52 were the main fingerprint features. The mean and P95 levels of ∑7PCBs ingested daily by Chinese residents through pork consumption were 0.062±0.076 （ng/kg·BW） and 0.158±0.207 （ng/kg·BW）， respectively， and the exposure risk index （ERI） was less than 1.ConclusionThe contamination level of ∑7PCBs in pork in China， as well as the health risk of residents exposed to indicator PCBs through a pork diet was low