A novel F-box protein affects the development of Drosophila melanogaster

F-box是一段大约50个氨基酸的蛋白质基序，其功能主要是作为蛋白质与蛋白质之间相互作用的结合位点。具有F-box基序的蛋白被统称为F-box蛋白。F-box蛋白家族最初被定义为SCF泛素化连接酶复合物（Skp1，Cullin和F-box蛋白）的成分之一，负责介导被降解的底物与Skp1之间的连接。F-box蛋白在细胞周期调控、转录调节、细胞凋亡、信号转导等生命活动中发挥着重要的作用。我们实验室在果蝇体内发现了一种新的F-box蛋白，将之命名为Fblp（F-boxlikeprotein）。Fblp在果蝇体内由CG4221基因编码，具有F-box基序，其功能尚未被了解。本文利用果蝇作为实验动物模型...The F-box is a protein motif of approximately 50 amino acids which functions as a site of protein-protein interaction. F-box protein family was first characterized as a component of SCF ubiquitin-ligase complexes (Skp1, Cullin, and an F-box protein), which binds degraded substrates for Skp1. F-box proteins play essential roles in various physiological and pathological processes, such as cell cycle...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2172009115216