纸花盆多孔自动打孔机机构设计

针对纸花盆打孔机人工操作劳动强度大、打孔精度低和工作效率低等问题,提出一款多孔自动打孔机构。然后通过建立数学模型,利用数学分析软件对此机械机构进行了分析优化;设计了能够很好地满足运动性能的凸轮轮廓,为以后研究和实体制作提供了有益的理论基础

Effect of collateral-pricking and cupping therapy combined with copper Bian scraping therapy on relieving zoster-associated pain (刺络拔罐联合铜砭刮痧改善带状疱疹患者疼痛症状效果观察)

Objective To investigate the effect of collateral-pricking and cupping therapy combined with copper Bian scraping therapy on relieving zoster-associated pain. Methods A total of 36 patients with herpes zoster who visited the Peking University People's Hospital from January 2021 to January 2023 were selected. They were randomly divided into an observation group and a control group using a random number table method, with 18 patients in each group. All patient patients received conventional drug treatment and nursing, and those in the observation group received collateral-pricking and cupping therapy combined with copper Bian scraping therapy every 3 days. Scores of Visual Analogue Scale (VAS), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were assessed before and after treatment. Results Decreases in VAS score both in resting and active states were observed in the two groups after treatment(P＜0. 05). Lower VAS scores were found both in resting and activating states in the observing group than in the control group after two sessions of treatment(P＜0. 01). Decreases in SDS and SAS score were observed in the two groups after treatment(P＜0. 05), and there was no significant difference in decreased of SDS and SAS score were between two groups. Conclusion The collateral-pricking and cupping therapy combined with copper Bian scraping therapy is effective to alleviate the pain level of patients with herpes zoster. (目的 探讨刺络拔罐联合铜砭刮痧改善带状疱疹患者疼痛症状的效果。方法 选取2021年1月—2023年1月北京大学人民医院中医科门诊及病房就诊的带状疱疹患者36例, 采用随机数字表法分为试验组和对照组, 各18例。对照组给予常规西药治疗和护理; 试验组在对照组基础上, 每隔3日在疱疹区刺络拔罐联合铜砭刮痧治疗。对比两组患者疼痛视觉模拟量表(VAS)评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分。结果 治疗1、2、3次和第1、2次随访时, 两组患者静息状态及活动状态VAS评分均较治疗前下降(P＜0. 05)。治疗2次后, 试验组静息和活动状态下VAS评分低于对照组, 且试验组VAS评分下降较对照组更明显(P＜0. 01)。治疗1、2、3次和第1、2次随访时, 两组患者SDS和SAS评分均较治疗前下降(P＜0. 05), 但评分变化无组间差异。结论 刺络拔罐联合铜砭刮痧能进一步缓解带状疱疹患者疼痛症状, 且操作方法简单。

头颈部动脉支架植入围手术期患者血清NETs标志物的动态变化（Dynamic Changes in Serum NETs Markers during the Perioperative Period in Patients Undergoing Head and Neck Arterial Stent Implantation）

目的 探讨头颈部动脉支架植入后血清中性粒细胞外陷阱（neutrophil extracellular traps，NETs）标志物瓜氨酸化组蛋白3（citrullinated histone 3，cit-H3）及髓过氧化物酶（myeloperoxidase，MPO）水平随时间变化的规律。 方法 前瞻性连续纳入因头颈部动脉粥样硬化性大动脉狭窄行支架植入术的患者，分别于术前空腹24 h内，术后6、12、24、48 h采集患者静脉血，测定血清cit-H3及MPO水平。采用经Greenhouse-Geisser校正的单因素重复测量方差分析，比较患者围手术期不同时间点血清cit-H3及MPO水平的动态变化趋势。根据支架植入部位（颅内 vs. 颅外）、支架植入数目（1个 vs. 2个）、责任血管是否为症状性狭窄，以及手术时脑梗死是否处于急性期（病程≤14 d），对血清cit-H3及MPO水平的变化进行亚组分析。 结果 本研究共纳入48例患者，平均年龄为（61.8±8.4）岁，男性42例（87.5%）。在整体患者中，血清cit-H3在术前及术后6、12、24、48 h的水平分别为（54.50±6.48）ng/mL、（56.73±6.50）ng/mL、（71.27±7.35）ng/mL、（53.53±17.35）ng/mL和（52.22±5.45）ng/mL；血清MPO在术前及术后6、12、24、48 h的水平分别为（25.45±6.67）ng/mL、（26.29±6.75）ng/mL、（28.28±7.68）ng/mL、（31.55±9.09）ng/mL和（28.68±7.61）ng/mL，两者术后水平均呈现先升高后降低趋势，整体差异均具有统计学意义（P=0.002；P=0.022）。颅外及颅内支架亚组、1个及2个支架亚组、症状性狭窄亚组及非急性期亚组的血清cit-H3水平均于术后12 h达到峰值。颅内支架亚组的血清MPO水平于术后12 h达到峰值，2个支架亚组、症状性狭窄亚组及非急性期亚组的血清MPO水平均于术后24 h达到峰值。 结论 头颈部动脉支架植入术后48 h内，血清NETs标志物cit-H3和MPO水平呈现先升高后恢复至术前水平的变化趋势，这种趋势在症状性狭窄患者中更显著。（Abstract: Objective To explore the dynamic changes over time in serum levels of neutrophil extracellular traps (NETs) markers—citrullinated histone 3 (cit-H3) and myeloperoxidase (MPO)—after head and neck arterial stent implantation. Methods Patients with atherosclerotic stenosis of the head and neck arteries who underwent stent implantation were prospectively and consecutively enrolled. Venous blood samples were collected from the patients within 24 hours of fasting before surgery, and at 6, 12, 24, and 48 hours after surgery to measure serum cit-H3 and MPO levels. One-way repeated measures analysis of variance with Greenhouse-Geisser correction was used to compare the dynamic changes in serum cit-H3 and MPO levels across different perioperative time points. Subgroup analyses of the changes in serum cit-H3 and MPO levels were conducted based on stent implantation site (intracranial vs. extracranial), number of stents implanted (1 vs. 2), whether the responsible vessel had symptomatic stenosis, and whether cerebral infarction was in the acute phase (disease duration≤14 days) at the time of surgery. Results A total of 48 patients were enrolled in this study with a mean age of (61.8±8.4) years, including 42 males (87.5%). Among all patients, the serum cit-H3 levels before surgery and at 6, 12, 24, and 48 hours after surgery were (54.50±6.48) ng/mL, (56.73±6.50) ng/mL, (71.27±7.35) ng/mL, (53.53±17.35) ng/mL, and (52.22±5.45) ng/mL, respectively. The serum MPO levels at the corresponding time points were (25.45±6.67) ng/mL, (26.29±6.75) ng/mL, (28.28±7.68) ng/mL, (31.55±9.09) ng/mL, and (28.68±7.61) ng/mL, respectively. Both markers showed a trend of increasing first and then decreasing, with statistically significant overall differences (P=0.002 for cit-H3; P=0.022 for MPO). In the extracranial and intracranial stent subgroups, the single and double stent subgroups, the symptomatic stenosis subgroup, and the non-acute phase subgroup, the serum cit-H3 levels peaked at 12 hours after surgery. The serum MPO levels peaked at 12 hours after surgery in the intracranial stent subgroup. However, in the double stent subgroup, the symptomatic stenosis subgroup, and the non-acute phase subgroup, the serum MPO levels peaked at 24 hours after surgery. Conclusions Within 48 hours after head and neck artery stent implantation, the serum levels of NETs markers cit-H3 and MPO showed an initial increase followed by a gradual return to preoperative levels. This trend was more pronounced in patients with symptomatic arterial stenosis.

Determination of the number of ψ(3686) events taken at BESIII

The number of ψ(3686) events collected by the BESIII detector during the 2021 run period is determined to be (2259.3±11.1)×106 by counting inclusive ψ(3686) hadronic events. The uncertainty is systematic and the statistical uncertainty is negligible. Meanwhile, the numbers of ψ(3686) events collected during the 2009 and 2012 run periods are updated to be (107.7±0.6)×106 and (345.4±2.6)×106, respectively. Both numbers are consistent with the previous measurements within one standard deviation. The total number of ψ(3686) events in the three data samples is (2712.4±14.3)×10^