Indigenous peoples' rights providing by international legal tools

According to the UN data, more than 300 million people in the world today are indigenous people in more than 70 countries, many of which are on the verge of extinction. Being heirs of unique cultures and having a different social, economic and political lifestyle, they try to preserve their way of life in a society dominated by a completely different culture. Throughout history, their rights were constantly violated in the crudest way; they were exterminated, deprived of their land and resettled in areas unsuitable for life. Now times have changed, and international law recognizes the right of indigenous peoples to restore historical justice and protect their traditional way of life. The paper analyzes the main international documents on the protection of the rights of indigenous peoples, the author traces the dynamics of the establishment and development of international standards in this field, which makes it possible to trace the evolution of international law, determine its role in the modern system of protecting the rights of indigenous peoples and assess the potential for the future

Fundamental solution of a multidimensional axisymmetric equation

© 2017 Informa UK Limited, trading as Taylor & Francis Group For the axisymmetric Helmholtz equation (Formula presented.) it is shown that fundamental solutions constructed by the Gellerstedt method and by means of a transmutation operator are coinciding

Fundamental solution of multidimensional axisymmetric Helmholtz equation

© 2016 Informa UK Limited, trading as Taylor & Francis GroupFor axisymmetric Helmholtz equation(Formula presented.) fundamental solutions have been constructed. Those are written explicitly via confluent Horn functions. The obtained fundamental solutions have been proved to possess a power singularity (Formula presented.)

Boundary value problem for B-parabolic equation with integral condition of the first kind

The article deals with the boundary value problem with integral condition of the first kind for a parabolic equation with Bessel operator, and proves its equivalence to the boundary value problem for the same equation with usual local boundary condition. Uniqueness of solution of the problem is proven. The said solution is made as a sum of series by eigenfunctions of the corresponding eigenvalue and eigenfunction problem

Double-layer potential of axially symmetric Helmholtz lowest term equation

© 2016,International Journal of Pharmacy and Technology. All rights reserved.1. The classical method for solving boundary value problems is the potential method. Potential kernels are recorded as linear combinations of normal derivatives of the fundamental solutions relating to the corresponding equations. For equations with constant coefficients,the fundamental solutions have,as a rule,a simple form. And as a consequence,it is not difficult to calculate any normal derivatives of them. This topic is described in some university textbooks. Due to numerous applications,the study of equations with singular coefficients is significant in the modern theory of differential equations with partial derivatives. The fundamental solutions are usually recorded as a power series for singular equations; they are limited to the first term in the further studies,and evaluation formulas are used for everything else. Finding a fundamental solution in an explicit form is in itself a significant result. 2. For a singular equation,which is the generalized Helmholtz equation,both with the lowest term and without it,a double-layer potential is found in this work. Potential kernel is a normal derivative of the fundamental solution. In order to find this derivative a special function unit is used. 3. The fundamental solution to the considered equation is expressed in terms of the confluent Horn function. Formula for calculating the normal derivative of this fundamental solution is obtained in the article. The result is written in an explicit form using the same Horn function. Relevance of calculating the normal derivative of the fundamental solution to the axially symmetric Helmholtz equation is determined by its demand in applications and absence of a general theory for this type of equations. 4. When using the formulas associated with the special hypergeometric functions,there was a wide choice to the authors. Using the so-called transformation formula,the result could be recorded in various ways,and not always compactly. The result is recorded in such a way that in calculating the limit values of the potentials the relevant terms will be able to be combined. 5. The potential constructed in this work can be applied to solve any boundary value problems for axially symmetric Helmholtz equation. According to the same scheme,potentials for higher-order equations can be constructed

Spin Crossover [Fe(qsal)2]X (X = Cl, SCN, CF3SO3) Complexes: EPR and DFT Study

The compounds [Fe(qsal)2]X (X = Cl, SCN, CF3SO3) were synthesized and investigated by electron paramagnetic resonance (EPR). The dependence of the Fe(III) spin state on the type of counterion X and on the temperature was established. On the basis of the density functional calculations, the geometrical parameters of compounds in high- and low-spin states were optimized and the difference in their internal energies was calculated. A correlation between the experimental EPR data and the theoretically calculated energy difference between the high-spin and the low-spin states of the compounds with different anions was obtained. © 2010 Springer-Verlag

Study of the time-differentiated particle flux density at various distances from EAS axis

The EAS time structure is studied using the enlarged EAS array of the Moscow State University. The time measurements are made using 22 scintillators which form 13 rectanges of 180x190 sq m size covering the entire array area. The array is triggered by a signal of 4-fold coincidences of the pulses from the detectors forming each of the rectangles. The data were obtained during 2200 hours of the array operation in 1984. A total of 816 showers, to which at least 14 of 22 scintillator detectors responded, were selected among all those detected. The coordinates of the EAS axis in the observation plane and the EAS sizes were determined by the maximum likelihood method using a computer on the assumption that the electron LDF is the NKG form. A total of 492 showers in the interval of EAS size Ne = 5x10 to the 6th power - 2x10 to the 8th power (N bar e = 1.7x 10 to the 7th power) with zenith angles theta or = 45 deg and axes within the array are analyzed

Norm and reference interval in biochemistry – similarities and differences

The article is devoted to the definition of the essence of the concepts "norm" and "reference interval ", their similarities and differences in biochemistrical diagnostics.Статья посвящена определению сущности понятий «норма» и «референсное значение», их сходстве и различии в биохимической диагностике

NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells

Epithelial ovarian cancer (EOC) accounts for the most gynecologic malignancy-associated deaths in the United States. Enhancer of zeste homolog 2 (EZH2), which silences gene expression through generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3), is often overexpressed in EOCs and has been suggested as a therapeutic target. However, the mechanism underlying EZH2 overexpression in EOCs is unknown. Here, we show that EZH2 is upregulated at the transcription level, and two CCAAT boxes in the proximal regions of the human EZH2gene promoter are critical for its transcription inEOCcells. Indeed, NF-YA, the regulatory subunit of the CCAAT-binding transcription factor NF-Y, is expressed at higher levels in human EOCs than in primary human ovarian surface epithelial (HOSE) cells. In addition, there is a positive correlation between expression of NF-YA and EZH2 in EOCs. Notably, high NF-YA expression predicts shorter overall survival in patients with EOCs. The association of NF-YA with the promoter of the human EZH2 gene is enhanced in human EOC cells compared with primary HOSE cells. Significantly, knockdown of NF-YA downregulates EZH2, decreases H3K27Me3 levels, and suppresses the growth of human EOC cells both in vitro and in a xenograft mouse model. Notably, NF-YA knockdown induces apoptosis ofEOCcells and ectopic EZH2 expression partially rescues apoptosis induced by NF-YA knockdown. Together, these data reveal that NF-Y is a key regulator of EZH2 expression and is required for EOC cell proliferation, thus representing a novel target for developing EOC therapeutics. © 2013 American Association for Cancer Research

Structure, stability, and ligand exchange of copper(II) complexes with oxidized glutathione

Formation constants and structures of copper(II) complexes with oxidized glutathione (L) have been determined by computer modelling of spectrophotometric and NMR relaxation measurements data over a wide range of pH (1-13) and metal and ligand concentrations in aqueous KNO3 (1 M) at 298 K. Among 11 found complexes, four forms were characterized for the first time. Based on a comparison of thermodynamic, relaxation, and optical and EPR spectroscopy parameters the structural conclusions were made. In particular, the CuLH 2 and CuLH- complexes both contain two isomers which are similar to mono- and bis-aminoacid copper(II) complexes. In the Cu2L and Cu3L2 2- species one of the copper atoms is bound only with the carboxylate or carbonyl groups and the others are coordinated similarly to aminoacid chelates. Along with the last, in Cu 2LH-2 2- two bridging OH- groups in one isomer or two chelate rings including deprotonated peptide nitrogen and glycinyl carboxylate oxygen in another are also present. In Cu3L 2H-4 6- the mixed variant of coordination between CuL2- (CuN2O2) and Cu 2LH-4 4- (CuN3O) is realized. The structures of polynuclear complexes have been optimized in density functional theory computations. Rate constants of ligand exchange reactions of Cu(LH) 2 4- and CuL2 6- with participation of the LH3- and L4- forms were determined for the first time. Factors determining rates of these processes have been revealed and their proceeding by associative substitution mechanism shown. © 2005 Elsevier Inc. All rights reserved