23 research outputs found
Supplementary data for the article: Šegan, S.; Opsenica, I.; Zlatović, M.; Milojković-Opsenica, D.; Šolaja, B. Quantitative Structure Retention/Activity Relationships of Biologically Relevant 4-Amino-7-Chloroquinoline Based Compounds. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2016, 1012–1013, 144–152. https://doi.org/10.1016/j.jchromb.2016.01.033
Supplementary material for: [https://doi.org/10.1016/j.jchromb.2016.01.033]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2059
Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028
Supporting information for: [https://doi.org/10.1021/acsinfecdis.5b00028]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2035
Supplementary data for article: Šegan, S. B.; Andrić, F.; Radoičić, A.; Opsenica, D. M.; Šolaja, B. A.; Zlatović, M.; Milojković-Opsenica, D. Correlation between Structure, Retention and Activity of Cholic Acid Derived Cis-Trans Isomeric Bis-Steroidal Tetraoxanes. Journal of Separation Science 2011, 34 (19), 2659–2667. https://doi.org/10.1002/jssc.201100185
Supporting information for: [https://doi.org/10.1002/jssc.201100185]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1212
Supplementary data for article: Šegan, S. B.; Trifković, J.; Verbić, T.; Opsenica, D. M.; Zlatović, M.; Burnett, J.; Šolaja, B. A.; Milojković-Opsenica, D. Correlation between Structure, Retention, Property, and Activity of Biologically Relevant 1,7-Bis(Aminoalkyl)Diazachrysene Derivatives. Journal of Pharmaceutical and Biomedical Analysis 2013, 72, 231–239. https://doi.org/10.1016/j.jpba.2012.08.025
Supplementary material for: [https://doi.org/10.1016/j.jpba.2012.08.025]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1555
Supplementary data for the article: Šegan, S.; Opsenica, I.; Zlatović, M.; Milojković-Opsenica, D.; Šolaja, B. Quantitative Structure Retention/Activity Relationships of Biologically Relevant 4-Amino-7-Chloroquinoline Based Compounds. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2016, 1012–1013, 144–152. https://doi.org/10.1016/j.jchromb.2016.01.033
Supplementary material for: [https://doi.org/10.1016/j.jchromb.2016.01.033]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2059
Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028
Supporting information for: [https://doi.org/10.1021/acsinfecdis.5b00028]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2035
Supplementary material for the article: Božinović, N.; Šegan, S.; Vojnovic, S.; Pavic, A.; Šolaja, B. A.; Nikodinovic-Runic, J.; Opsenica, I. M. Synthesis and Anti-Candida Activity of Novel Benzothiepino[3,2-c]Pyridine Derivatives. Chemical Biology and Drug Design 2016, 88 (6), 795–806. https://doi.org/10.1111/cbdd.12809
Supplementary material for: [https://doi.org/10.1111/cbdd.12809]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2346]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3620
Supplementary data for article: Šegan, S. B.; Andrić, F.; Radoičić, A.; Opsenica, D. M.; Šolaja, B. A.; Zlatović, M.; Milojković-Opsenica, D. Correlation between Structure, Retention and Activity of Cholic Acid Derived Cis-Trans Isomeric Bis-Steroidal Tetraoxanes. Journal of Separation Science 2011, 34 (19), 2659–2667. https://doi.org/10.1002/jssc.201100185
Supporting information for: [https://doi.org/10.1002/jssc.201100185]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1212
Supplementary data for article: Šegan, S. B.; Trifković, J.; Verbić, T.; Opsenica, D. M.; Zlatović, M.; Burnett, J.; Šolaja, B. A.; Milojković-Opsenica, D. Correlation between Structure, Retention, Property, and Activity of Biologically Relevant 1,7-Bis(Aminoalkyl)Diazachrysene Derivatives. Journal of Pharmaceutical and Biomedical Analysis 2013, 72, 231–239. https://doi.org/10.1016/j.jpba.2012.08.025
Supplementary material for: [https://doi.org/10.1016/j.jpba.2012.08.025]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1555
Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria
Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC50 values for such derivatives ranged from 0.81 to 2.27 mu M). Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors with nanomolar-range potencies (e.g., the K-i of compound 67 is 0.10 mu M). During BoNT/A challenge using primary neurons, select derivatives protected SNAP-25 by up to 89%. Docking simulations were performed to rationalize the compounds' in vitro potencies. In addition to specific residue contacts, coordination of the enzyme's catalytic zinc and expulsion of the enzyme's catalytic water were a consistent theme. With respect to antimalarial activity, the compounds provided better IC90 activities against chloroquine resistant (CQR) malaria than CQ, and seven compounds were more active than mefloquine against CQR strain W2