GAP Bölgesi Mevcut Su Kaynakları ve Tesislerinin Organik Balık Yetiştiriciliği Bakımından İncelenmesi Projesi

Bu projede, GAP Bölgesi’nde bulunan klasik su ürünleri yetiştiriciliği yapan işletmeler ve su kaynakları organik balık yetiştiriciliği açısından incelenmiştir. Araştırma, GAP Bölgesi’ nde ki 9 ilde yer alan su ürünleri işletmelerinde ve organik balıkçılık için uygun olabilecek su kaynaklarında yapılmıştır. Halkın beslenme alışkanlığını ve organik tarım konusunda bilgisini, düşüncesini ve potansiyelini ortaya koymak amacıyla; Bölgede bulunan 9 ilde 881 kişiyle, konuyla ilgili anket formu doldurularak, değerlendirilmiştir. Bölgede mevcut 26 adet klasik su ürünleri tesisinde araştırmalar yapılarak, işletme sahipleriyle anket çalışmasında bulunulmuştur. Tesiste kullanılan su kaynağının bazı fiziksel ve kimyasal özelliklerine de bakılmıştır. GAP Bölgesi’nde klasik balıkçılık yapan su ürünleri tesisinden, 9’u kafes balıkçılığı, 17’si havuz balıkçılığı yapmaktadır. Bölgenin toplam su ürünleri yetiştiricilik miktarı 310 ton/yıl’dır. Bu ürünün; 105 ton/yıl’ı havuz balıkçılığı, 205 ton/yıl’ı kafes balıkçılığı ile elde edilmektedir. Su ürünleri işletmelerinin faaliyet yerine, çevresine, su kalitesine, havuz veya kafes yapısına, dizaynına, kuluçkahanesine, hayvan refahına, diğer klasik işletmelere yakınlığına ve işletme sahibinin bilgisine bakılarak; organik balıkçılıkla ilgili değerlendirmeler yapılmıştır. Bu değerlendirmeler neticesinde, Bölgede mevcut durumda faaliyet gösteren tesislerin, organik su ürünleri yetiştiriciliğine uygun şartları taşımadığı sonucuna varılmıştır. Klasik balıkçılık için dahi yetersiz olan bu işletmelerde, mevcut durumda organik balıkçılığın yapılması mümkün değildir. Bölgede bulunan ve ön araştırmalar sonucu debisi yeterli olup, organik balıkçılık için uygun olabilecek özellikteki 17 adet su kaynağının çevresel, fiziksel ve kimyasal özelliklerine mevsimsel olarak bakılarak, değerlendirmelerde bulunulmuştur. Bu değerlendirmeler neticesinde; organik balık yetiştiriciliği yapılabilecek su kaynaklarının Tavaş, Hapşeri, Zebran ve Fırat Irmağı (Atatürk ve Birecik Barajı çıkış suyu)’ nın olduğu belirlenmiştir

The effect of antimicrobial policy implementation on carbapenem resistance: A university hospital experience

Objective: The resistance of Gram-negative bacteria to antibiotics is a global issue that leads to increased mortality and treatment costs. The aim of this study is to see how a newly formed carbapenem control team affected the prevalence of carbapenem-resistant Gram-negative rods and antibiotic consumption expenses in 2017 compared to the year before.Methods: The rate of carbapenem antibiotic usage in Intensive Care Units and Bone Marrow Transplantation services, as well as the findings of culture materials obtained from various body parts of the same patients, between January 1, 2016, and December 31, 2017 were assessed.Results: While there was an ordinary restriction on carbapenem consumption in 2016, carbapenem consumption has been more restricted in 2017. The carbapenem-resistant Gram-negative bacteria patterns of culture materials are examined and compared with Defined Daily Dose data of carbapenems. After the restriction, a significant decrease in the consumption of carbapenems was detected. The decline in carbapenem-resistant Gram-negative bacteria and decreasing antibiotic consumption were found to have a moderately positive correlation (r=0.641, p=0.02). A 60.9% decrease was observed in carbapenem costs after carbapenem restriction, on the other hand, an increase in other unrestricted antibiotics was apparent.Conclusion: Antimicrobial restriction policies can help minimize the rate of carbapenem-resistant Gram-negative rods, which is a serious problem in healthcare. We demonstrated that a decrease in carbapenem-resistant Gram-negative rods isolation rates can lead to a decrease in healthcare-associated infections. Although there is no decrease in the direct antibiotics cost, a drop in carbapenem-resistant may lower the expenses of drastic consequences of infections with carbapenem-resistant and its cost. we can conclude that the Antibiotic Control Policy should be modified based on this new information

The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests

A Weighted Multiobjective Optimization Method for Mixed-Model Assembly Line Problem

Mixed-model assembly line (MMAL) is a type of assembly line where several distinct models of a product are assembled. MMAL is applied in many industrial environments today because of its greater variety in demand. This paper considers the objective of minimizing the work overload (i.e., the line balancing problem) and station-to-station product flows. Generally, transportation time between stations are ignored in the literature. In this paper, Multiobjective Mixed-Integer Programming (MOMIP) model is presented to optimize these two criteria simultaneously. Also, this MOMIP model incorporates a practical constraint that allows to add parallel stations to assembly line to decrease higher station time. In the last section, MOMIP is applied to optimize the cycle time and transportation time simultaneously in mixed-model assembly line of a real consumer electronics firm in Turkey, and computational results are presented

Scalp recurrence of cholangiocarcinoma after curative hepatectomy: A report of two cases

Cholangiocarcinomas are the second most common primary liver malignancies. The lymphatics are the common route of metastatic spread for cholangiocarcinomas. The most frequent sites of metastasis are the liver, abdominal lymph nodes, peritoneum and lungs. Cutaneous metastasis of cholangiocarcinoma is rare, and most commonly occurs following percutaneous biliary drainage. Brain or skull metastases from this tumor are uncommon. However, these rare metastatic lesions may occasionally be the first disease manifestation, although scalp recurrence following curative treatment is uncommon. We herein present the cases of two patients with cholangiocarcinoma, who were evaluated as resectable based on the criteria for cholangiocarcinoma resectability, and developed scalp recurrence following curative hcpatectomy. Therefore, although scalp recurrence is a rare occurrence following curative treatment for cholangiocarcinoma, metastases should be included in the differential diagnosis

KOBİ’lerde Girişimcilik Değerleri ve Dış Ticaret Faaliyetleri Arasındaki İlişki: Sanayi İşletmeleri Örneği - The Relationship Between The Values Of Entrepreneurship And Foreign Trade Activities In SME’s: The Case Of Industrial Enterprises

Nowadays, SME’s and entrepreneurs have important roles in the national and international economy in terms of countries. SME’s and entrepreneurs have several advantages in competitive market economy. These advantages are adapting increasing competition, gaining knowledge of market and production, undertaking the risks that may occur, adapting quickly to innovations in the organization. In this study, it is analyzed relationship between SME’s entrepreneurship values and foreign trade activities. It has been included to study that foreign trade firms in Ankara, Istanbul, Adana, Mersin, Bursa and Kocaeli in order to evaluate their views of foreign trade activities and determine relationship between entrepreneurship and foreign trade. In the scope of the research, it is used primary data that belong to 180 SMEs. The empirical result of research shows that there are positive relationship between entrepreneurship values and foreign trade