21 research outputs found
Zesp贸艂 samotnego wrzodu odbytnicy i enterocele u 13-letniego ch艂opca
Zesp贸艂 samotnego wrzodu odbytnicy (solitary rectal ulcer syndrome - SURS) jest rzadkim schorzeniem u dzieci i m艂odzie偶y.
Zwykle objawia si臋 zaburzeniami oddawania stolca i b贸lami
brzucha. Powszechnie uwa偶a si臋, 偶e w patogenezie tego schorzenia odgrywaj膮 rol臋 zaburzenia defekacji. W niniejszej pracy
przedstawiono opis przypadku 13-letniego ch艂opca z zespo艂em
nadpobudliwo艣ci psychoruchowej i SURS. G艂贸wnymi objawami,
kt贸re zg艂asza艂 pacjent, by艂y: zwi臋kszona cz臋sto艣膰 oddawania
stolca z obecno艣ci膮 艣luzu, okresowe krwawienia z odbytnicy,
uczucie parcia na stolec i niepe艂nego wypr贸偶nienia oraz b贸le
brzucha. W badaniu kolonoskopowym stwierdzono okr臋偶ne
owrzodzenie i uniesion膮, nieregularn膮 zmian臋 si臋gaj膮c膮 esicy
z typowym dla SURS obrazem mikroskopowym. Defekografia
uwidoczni艂a typowy dla enterocele obraz wpuklenia si臋 p臋tli jelita cienkiego w 艣cian臋 prostnicy. Ch艂opcu i jego matce wyja艣niono 艂agodny, chocia偶 przewlek艂y, charakter schorzenia. Leczenie
zachowawcze obejmowa艂o zalecenie unikania wysi艂kowego oddawania stolca oraz stosowanie diety bogatob艂onnikowej, aby
zapobiega膰 zaparciom. W SURS obraz zmian makroskopowych
jest bardziej r贸偶norodny, ni偶 powszechnie si臋 uwa偶a. Ustalenie
w艂a艣ciwego rozpoznania zale偶y w du偶ej mierze od wnikliwo艣ci
zar贸wno klinicysty, jak i patologa.Solitary rectal ulcer syndrome (SRUS) is a rare disorder of childhood, which usually presents with any of the manifestations of
anorectal disease, bowel habit alteration and abdominal pain.
It is commonly accepted that pathogenesis is associated with
disturbances of defecation. We describe a 13-year-old boy with
attention deficit hyperactivity disorder (ADHD) and SRUS. He
complained of increased stool frequency associated with the
passage of blood and mucus, tenesmus, sensation of incomplete defecation and abdominal pain. Circumferential ulcer
and flat lesion extending up to the sigmoid colon with typical
microscopic findings were revealed upon colonoscopy.
Defecography showed an opacified small bowel invaginating
into the rectal wall, the pictures consistent with enterocele.
Conservative treatment, including reassuring the patient and
his mother of the benign nature of the disease, recommendation to avoid straining defecation and use of a high-fiber diet
to prevent constipation, was applied. The macroscopic appearance of rectal lesions in SRUS are much more variable than is
usually realized. An early diagnosis requires a high index of
suspicion both for clinicians and the pathologist
Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development
Background The prevalence of autoimmune thyroiditis
(AIT) and papillary thyroid carcinoma (PTC) is rising in
children and adolescents, and the coincidence of AIT and
PTC is as high as 6.3-43%.
Objective To investigate the ultrasound manifestation of
AIT in relation to PTC development in paediatric patients.
Patients 179 paediatric patients (133 females), mean (SD)
age: 13.9 (3.03) years diagnosed with AIT and referred for
ultrasound evaluation. Eight patients were diagnosed with
PTC (6 females).
Methods Retrospective analysis of thyroid ultrasound
scans of patients diagnosed with AIT. Thyroid and autoimmune
status was assessed based on TSH, fT4, fT3 and
increased aTPO and/or aTG and/or TRAB levels. In patients
with PTC, total thyroidectomy was performed.
Results Analysis of thyroid US scans revealed that the following
five ultrasound variants of AIT were observed in
179 patients: the most common in 35.2%-diffuse thyroiditis
with hypoechogenic background and normoechogenic
parenchyma, in 30.2%-diffuse thyroiditis with irregular background, in 18.9% nodular variant with normoechogenic
background, in 11.7%-micronodulations and in 3.9%-diffuse
hypoechogenic background. Eight cases of PTC were
diagnosed in nodular variant of AIT with normoechogenic
irregular background.
Conclusion Patients with AIT and nodular variant with
normoechogenic irregular background of the thyroid gland
on US scans are in the risk group of developing PTC and
should be followed up with regular neck US assessment
Hereditary hemorragic teleangiectasia in 13-month aged children: case report and review of the literature
Novel insights in ultrasound evaluation of thyroid gland in children with papillary thyroid carcinoma
Wrodzona naczyniakowato艣膰 krwotoczna rozpoznana u 13-miesi臋cznego dziecka: opis przypadku i przegl膮d literatury
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant, rare and severe disease that results from vascular dysplasia. It is characterised by recurrent epistaxis, teleangiectasias of skin and mucosa and arteriovenous malformations in: lungs, brain, liver, gastrointestinal tract and spinal cord. Diagnosis of HHT is rarely done in early childhood, because of the gradual appearance of vascular malformations. Patients with HHT require complex, multidisciplinary management, because of heterogeneity of clinical manifestations, risk of potentially life-threatening complications and poor prognosis especially in case of multiple visceral teleangiectasia. Here we report a case of severe HTT with diffuse pulmonary arteriovenous malformations in 13-month-old child with negative family history, who presented with polyglobulia and development retardation. On the basis of literature review we present current recommendations for diagnosis and management in HHT, in particularly in the case of diffuse pulmonary arteriovenous malformations, disqualified from any interventional procedures and associated with a poor prognosis
Single-agent MOR208 salvage and maintenance therapy in a patient with refractory/relapsing diffuse large B-cell lymphoma : a case report
Background: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin鈥檚 lymphoma. Standard
first-line treatment for this aggressive subtype comprises the anti-CD20 antibody rituximab combined with
cyclophosphamide, doxorubicin, vincristine, and prednisone. If patients receiving such treatment have an early
relapse, or their disease is initially refractory to such treatment, standard salvage regimens may not be effective.
There is therefore a high unmet clinical need for new targeted agents that might improve the outcome for such
patients. CD19 is a B-lymphocyte lineage-specific cell surface antigen that is expressed by most B-cell non-Hodgkin's
lymphomas. MOR208 is an fragment-crystallizable engineered humanized monoclonal antibody with enhanced
antitumor activity that targets CD19 and that may consequently have clinical utility in this setting.
Case presentation: We describe the case of a 33-year-old Caucasian man who presented with a 3-month history of
general symptoms and who was admitted to our pulmonology ward with dyspnea due to pneumonia and severe
anemia. A histopathological examination of an enlarged right suprasternal lymph node confirmed a diagnosis of T-cell/
histiocyte-rich large B-cell lymphoma, an uncommon morphological variant of diffuse large B-cell lymphoma. Our
patient had a complete response to first-line rituximab combined with cyclophosphamide, doxorubicin, vincristine, and
prednisone, but had an early relapse 5 months after the end of treatment. After intensive salvage therapy consolidated
with an autologous stem-cell transplant, our patient again had an early relapse and was subsequently enrolled in a
phase IIa trial of single-agent MOR208. Following a scheduled 3 months of weekly treatment, a partial response was
confirmed and MOR208 was continued as maintenance therapy, with administration every second week. Positron
emission tomography-computed tomography confirmed a complete response 9 months later. This response is ongoing,
with a duration of 24 months. MOR208 was well-tolerated by our patient and his quality of life and performance status
remain high. No hospitalizations were required and our patient engaged in full-time work and physical activities.
Conclusion: Third-line single-agent therapy with the CD19 antibody MOR208 was highly effective in this patient, despite
a history of early relapse after standard first-line and second-line treatment regimens. These data provide support for
future randomized studies of MOR208
Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma
Purpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not
have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal
changes in the thyroid gland prior to the development of PTC.
Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327,
12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%)
presenting this variant were diagnosed with PTC (nine females-mean age 15.3 years; two males aged 11 and 13 years). In
five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation.
For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid
scans and these patients were selected for analysis in this study.
Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a
hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No
thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during
the follow-up. PTC developed in a mean time of 4.6 years (1 9/12-7 4/12 years) since referral to the outpatient thyroid clinic
and 2.9 years (6/12-6 9/12) since the last nodule-free US thyroid scan.
Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility
in the paediatric population
Genetic profile and clinical implications of hepatoblastoma and neuroblastoma coexistence in a child
Economic Determinants of Low-Carbon Development in the Visegrad Group Countries
Low-carbon development is one of the more significant problems of the Visegrad Group countries (Czech Republic, Poland, Slovakia, and Hungary). It is related, among others, to the improvement of life quality in economic terms while taking into account activities for environmental protection. The aim of the article is to identify and explain the problems connected with low-carbon development. The purpose of the analyses is also to prove the negative impact of the emission of greenhouse gas emission (GHG) and other harmful substances into the air on the quality of human life and the natural environment. During the research, an assessment of the eco-efficiency of the used energy resources and technologies that negatively affect the environment was carried out. Moreover, the paper also presents methods to use greener energy sources and analyses the potential of implementing solutions supporting low-carbon development. The study recommends actions that may contribute to the reduction of greenhouse gas emissions. These include the limitation of the use of fossil fuels for the benefit of renewable energy and the development of distributed energy