HA PEGylated Filler in Association with an Infrared Energy Device for the Treatment of Facial Skin Aging: 150 Day Follow-Up Data Report

Background: The face is the area most exposed to the normal course of skin aging, both intrinsically and extrinsically. The aim of the study was to evaluate the cellular and clinical response of a therapeutic protocol aimed at countering facial skin aging. Materials and methods: Twenty female patients with facial skin laxity and photodamage underwent combined therapy including mesotherapy using non-cross-linked hyaluronic acid with calcium hydroxyapatite and an infrared energy-based device treatment with subsequent implementation of PEG-cross-linked hyaluronic acid soft tissue fillers. To evaluate the benefits, patients underwent histological, immunological, and biomechanical evaluations before the treatment and at 21 and 150 days after the treatment. Results: The histological results at 21 days and 150 days after the procedure showed an increase in the number of fibroblasts and angiogenesis. As for the immunological aspect, it was shown that the treatment has an immunomodulating action, avoiding the activation of CD4 and CD8 cells. Biomechanical data showed that, at 150 days after treatment, the average changes in skin elasticity increased by 72% and the skin hydration increased by 49%. Conclusions: A combination of an infrared energy-based device treatment with both non-cross-linked hyaluronic acid and novel PEG-cross-linked hyaluronic acid leads to numerous positive cutaneous changes after histological, immunological, and biomechanical evaluations

Zastosowanie środowiska wirtualizacyjego do zabezpieczenia danych w systemach przetwarzania danych eksploatacyjnych

This paper presents a concept, developed and tested by the authors, of a virtualisation environment enabling the protection of aggregated data through the use of high availability (HA) of IT systems. The presented solution allows securing the central database system and virtualised server machines by using a scalable environment consisting of physical servers and disk arrays. The authors of this paper focus on ensuring the continuity of system operation and on minimising the risk of failures related to the availability of the operational data analysis system.Niniejszy artykuł przedstawia koncepcję środowiska wirtualizacyjnego umożliwiającego zabezpieczenie agregowanych danych poprzez zastosowanie wysokiej dostępności (HA) systemów informatycznych. Przedstawione rozwiązanie pozwala zabezpieczyć centralny system bazodanowy oraz zwirtualizowane maszyny serwerowe poprzez wykorzystanie skalowalnego środowiska składającego się z fizycznych serwerów oraz macierzy dyskowych. Autorzy pracy skupiają się na zapewnieniu ciągłości działania systemów oraz na minimalizacji ryzyka awarii związanych z dostępnością systemu analizy danych eksploatacyjnych

Performance analysis of mobile applications developed with different programming tools

This study examines the efficiency of certain software tasks in applications developed using three frameworks for the Android system: Android SDK, Qt and AppInventor. The results obtained using the Android SDK provided the benchmark for comparison with other frameworks. Three test applications were implemented. Each of them had the same functionality. Performance in the following aspects was tested: sorting a list of items using recursion by means of the Quicksort algorithm, access time to a location from a GPS sensor, duration time for reading the entire list of phone contacts, saving large and small files, reading large and small files, image conversion to greyscale, playback time of a music file, including the preparation time. The results of the Android SDK are good. Unexpectedly, it is not the fastest tool, but the time for performing most operations can be considered satisfactory. The Qt framework is overall about 34% faster than the Android SDK. The worst in terms of overall performance is the AppInventor: it is, on average, over 626 times slower than Android SDK

Performance analysis of mobile applications developed with different programming tools

This study examines the efficiency of certain software tasks in applications developed using three frameworks for the Android system: Android SDK, Qt and AppInventor. The results obtained using the Android SDK provided the benchmark for comparison with other frameworks. Three test applications were implemented. Each of them had the same functionality. Performance in the following aspects was tested: sorting a list of items using recursion by means of the Quicksort algorithm, access time to a location from a GPS sensor, duration time for reading the entire list of phone contacts, saving large and small files, reading large and small files, image conversion to greyscale, playback time of a music file, including the preparation time. The results of the Android SDK are good. Unexpectedly, it is not the fastest tool, but the time for performing most operations can be considered satisfactory. The Qt framework is overall about 34% faster than the Android SDK. The worst in terms of overall performance is the AppInventor: it is, on average, over 626 times slower than Android SDK

Evaluation of the Safety of Neauvia Stimulate Injectable Product in Patients with Autoimmune Thyroid Diseases Based on Histopathological Examinations and Retrospective Analysis of Medical Records

The aim of this study was to test the effect of hyaluronic acid cross-linked with polyethylene glycol containing micronized portions of calcium hydroxyapatite (Neauvia Stimulate) on both local tissue and systemic consequences, which are crucial from the perspective of long-term safety, in patients suffering from Hashimoto’s disease. This most common autoimmune disease is a frequently mentioned contraindication to the use of fillers based on hyaluronic acid as well as biostimulants based on calcium hydroxyapatite. Broad-spectrum aspects of histopathology were analyzed to identify key features of inflammatory infiltration before the procedure and 5, 21, and 150 days after the procedure. A statistically significant effect on the reduction of the intensity of the inflammatory infiltration in the tissue in relation to the state before the procedure was demonstrated, combined with a reduction in the occurrence of both antigen-recognizing (CD4) and cytotoxic (CD8) T lymphocytes. With complete statistical certainty, it was demonstrated that the treatment with Neauvia Stimulate had no effect on the levels of these antibodies. All this corresponds with the risk analysis that showed no alarming symptoms during the time of observation. The choice of hyaluronic acid fillers cross-linked with polyethylene glycol should be considered justified and safe in the case of patients suffering from Hashimoto’s disease