The Association Between Hepatit B Virus (HBV) DNA Levels, Alanin Aminotransferaz Levels And HBV Serologic Markers

In the present study, we planned to evaluate the association between serum alanin aminotransferaz (ALT) levels, age, gender, and Hepatitis B virus (HBV) serologic markers of the patients whose HBV DNA levels were 10(4) copy/mL and higher. HBV DNA was quantitatively detected by real-time polymerase chain reaction (PCR) and serologic markers by enzyme immunoassay (EIA). Of the 322 sera which were tested for HBV DNA and HBV serology, 136 (42.2%) patients had HBV DNA levels between 10(4)-10(7) copy/mL and 186 (57.8%) had HBV DNA levels higher than 10(7) copy/mL. ALT levels were more than two times the upper limit of normal in 131 (40.6%) patients and less than two times the upper limit of normal in 191 (59.4%) patients. Of the patients, 96 (29.8%) were HBeAg positive and 266 (70.2%) were HBeAg negative. Of the study population, 63.7% of the patients were males and 36.3% of the patients were females. When the patients were evaluated according to the age distribution, the largest rate of the patients (51.8%) was within the range of 21-40 years. HBV DNA levels, HBV serology, liver enzymes and the clinical findings should be considered together during the diagnosis, treatment and the follow-up of the patients with HBV infection