mRNA expression levels of elastin, fibulin-5, LOXL-1, MMP-2 and MMP-9 in patients with varicose vein

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Aim: The reason of varicose vein formation is not exactly known yet; but some morphological and physiological changes of venous wall are thought to be responsible. One of those suspected reasons is the changes in quantity and content of elastin protein. There are some recent researches about elastin protein in various other diseases, but there is not enough comprehensive investigations about the mechanisms of elastin assembly in varicose vein formation. In this study, we aimed to investigate the changes in mRNA levels of elastin and some of its related proteins in formation of varicose veins

Analysis of L-MYC gene polymorphism in patients with renal failure outcome to renal transplant

Background. Abnormalities of cell numbers and apoptosis have been observed in renal failure. As uncontrolled expression of c-myc is known to induce apoptosis, we thought that polymorphism in the other myc gene, L-myc gene, which is structually similar to c-myc and reported to be expressed in the kidney, may have a role in the induction of apoptosis and thus have role in chronic renal failure. The aim of this study was to investigate the relationship between the distribution of L-myc genotypes and renal failure