3 research outputs found
Adiponectin: is it a biomarker for assessing the disease severity in knee osteoarthritis patients?
AimThe results of previous studies regarding the role of adiponectin in the pathogenesis of osteoarthritis (OA) are controversial. The aim of this study is to investigate the relation of plasma adiponectin levels with clinical and radiological disease severity in knee OA patients. MethodSixty patients with knee OA and 25 healthy controls were included in the study. Patients were divided into two subgroups: lean (Group 1, n = 30) and obese (Group 2, n = 30). Healthy controls were accepted as Group 3 (n = 25). Pain intensity was measured with a visual analogue scale (VAS), functional disability with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Quality of Life (QoL) with Short Form-36 (SF-36). Also all patients were radiologically evaluated and graded according to Kellgren-Lawrence (KL) scale. Plasma concentrations of adiponectin levels were measured by enzyme-linked immune-sorbent assay (ELISA). ResultsSerum adiponectin levels were higher in OA patient subgroups than those in the control group but the difference did not reach a significant level after adjustments for age, gender and body mass index (P = 0.078). There was a positive correlation between adiponectin concentration and KL grading scores. Additionally, there was a positive correlation between adiponectin levels and clinical variables (VAS and WOMAC total scores) in patient subgroups (r = 0.326 P = 0.012, r = 0.583 P < 0.001, respectively). SF-36 scores were inversely associated with adiponectin levels. ConclusionPlasma adiponectin concentrations were associated with both clinical and radiological disease severity in knee OA patients. Thus, adiponectin hormone might be a potential clinically useful biomarker while assessing disease severity in the future.Turkish League Against Rheumatism (TLAR)This study was funded by Turkish League Against Rheumatism (TLAR)
Adiponectin: Is it a biomarker for assessing the disease severity in knee osteoarthritis patients?
Aim: The results of previous studies regarding the role of adiponectin in the pathogenesis of osteoarthritis (OA)
are controversial. The aim of this study is to investigate the relation of plasma adiponectin levels with clinical
and radiological disease severity in knee OA patients.
Method: Sixty patients with knee OA and 25 healthy controls were included in the study. Patients were divided
into two subgroups: lean (Group 1, n = 30) and obese (Group 2, n = 30). Healthy controls were accepted as
Group 3 (n = 25). Pain intensity was measured with a visual analogue scale (VAS), functional disability with
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Quality of Life (QoL) with
Short Form-36 (SF-36). Also all patients were radiologically evaluated and graded according to Kellgren–Lawrence
(KL) scale. Plasma concentrations of adiponectin levels were measured by enzyme-linked immune-sorbent
assay (ELISA).
Results: Serum adiponectin levels were higher in OA patient subgroups than those in the control group but the
difference did not reach a significant level after adjustments for age, gender and body mass index (P = 0.078).
There was a positive correlation between adiponectin concentration and KL grading scores. Additionally, there
was a positive correlation between adiponectin levels and clinical variables (VAS and WOMAC total scores) in
patient subgroups (r = 0.326 P = 0.012, r = 0.583 P < 0.001, respectively). SF-36 scores were inversely associated
with adiponectin levels.
Conclusion: Plasma adiponectin concentrations were associated with both clinical and radiological disease
severity in knee OA patients. Thus, adiponectin hormone might be a potential clinically useful biomarker while
assessing disease severity in the future
Ankara'nın simgesi : Atakule
Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2013.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Sadiye Sena Dinçyürek.Dinçyürek, Sadiye Sena. HIST 200-14DİNÇYÜREK HIST 200-14/2 2012-1