Does the use of Bispecteral Index reduce the oxidative stress in Endoscopic Retrograde Pancreoticocolangiography?

Background: Endoscopic Retrograde Pancreoticocolangiography (ERCP) is performed for resolving cholestasis by sphincterotomy and/or stone extraction and is done with deep sedation or general anesthesia.Aim: Our aim was to evaluate the effects of the depth of anesthesia on oxidative stress provided via Bispecteral Index (BIS) monitorisation during the ERCP procedure by analyzing the biochemical parameters. And also was the effects of anesthesia depth on propofol consumption and postoperative sedation status.Methods: 50 patients undergoing ERCP procedure were randomly allocated in two groups. Propofol was given to provide the patients Ramsey sedation scale as 3 and 4 in Group R (n=25) patients whereas it was given to Group B (n=25) patients to provide BIS values between 65 to 85. The levels of total oxidant status (TOS), total antioxidant status (TAS), and OSI were measured. Hemodynamic signs, propofol consumption, postoperative recovery time were recorded.Results: TAS and OSI values were similar between the groups but TOS levels were significantly lower in Group B (p=0.027). Heart rate and mean arterial pressures of Group R were significantly higher than Group B. Propofol consumption and postoperative recovery time were smaller in Group B patients (p=0.001, p=0.000).Conclusion: In patients undergoing ERCP, using adequate sedation by BIS monitoring, may not only allow us to avoid unnecessary anesthetic drug consumption but also decrease the oxidant status.</p