Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity

Background. Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with unknown etiology. This report aims to present a case of LCH with diffuse involvement of the oral cavity and to raise awareness of the distinguishing features of this diagnostically challenging entity. Case Report. A 26-year-old male patient presented with complaints of teeth mobility, intense pain, and difficulty in chewing. Intraoral and radiological examinations revealed generalized gingival hyperplasia and severe teeth mobility with widespread alveolar bone loss. Periodontal therapy was performed with no significant improvement. An incisional biopsy revealed Langerhans cells and positive reaction to S-100 and CD1, and the patient was diagnosed with LCH. The patient underwent systemic chemotherapy with vinca alkaloids and corticosteroids. Regression of gingival lesions, as well as significant decrease in mobility of the remaining teeth and severity of pain, was achieved during 12 months of follow-up. Conclusion. The rarity and variable system involvement of LCH necessitate a multidisciplinary approach be carried out for accurate diagnosis, effective treatment, and an uneventful follow-up. Awareness of oral manifestations of LCH may aid clinicians greatly in reducing morbidity and mortality associated with this debilitating condition

Early Chalcolithic Pottery from Tepecik-Çiftlik and Gelveri, Central Anatolia: From Local to Supra-Regional Ceramic Style

We intend to decipher both a chronological and a cultural problematic raised by the sudden appearance of geometric incised decorations on Anatolian pottery, seemingly at the beginning of the sixth millennium cal B.C. Frequently designated as ‘Gelveri type’ in reference to the Gelveri-Güzelyurt Cappadocian pottery assemblage, the lack of a reliable chronology based on a good stratigraphy at the site made it difficult to cope with the nature of the development of such pottery style. Excavations at Tepecik-Çiftlik as well as recent archaeological work at Gelveri have provided us with new stratigraphic and decoration-related technological evidence. Hence, we have the possibility to analyse the emergence and the development of such pottery styles within a reliable archaeological context. Seen on such a large geographical scale, covering at least the entire Anatolian plateau, the nature of this pottery style development cannot be considered as a pottery phenomenon in itself only. It is necessary to investigate the cultural interactions at play, enabling stylistic patterns to be shared within different cultural areas

The Preliminary Report on the 2019-2020 Seasons of the Central Taurus Prehistoric Research Project (OTTA)

Des travaux de terrain ont été menés en 2019 et 2020, par le Central Taurus Prehistoric Research Project, dans les districts d’Erdemli, de Tarsus et de Çamlıyayla à Mersin. Le projet s’est fixé deux buts principaux : mieux connaître la chronologie régionale qui présente encore des lacunes importantes et comprendre le rôle tenu par le centre du Taurus et la Cilicie dans les relations culturelles interrégionales. Des campements éphémères, des grottes avec des niveaux d'occupation et des ateliers de taille de silex ont été découverts en nombre lors de ces deux premières saisons. Ces recherches ont permis de comprendre que la région était pour les communautés préhistoriques une zone d’occupation majeure depuis le Paléolithique. Dans cet article, nous décrivons les sites archéologiques identifiés et nous publions des données ethnobotaniques et une étude des chemins employés à travers les montagnes de Bolkar afin de mieux percevoir les zones de passage interrégionales au cours de la Préhistoire.Field work was carried out in 2019 and 2020 by the Central Taurus Prehistoric Research Project in the districts of Erdemli, Tarsus and Çamlıyayla of Mersin. The project aimed to fill the chronological gaps in the prehistoric chronology of the region, as well as to understand the role of Central Taurus and Cilicia in interregional cultural relations. The numerous temporary camps, caves with occupation debris and flint workshops revealed during the first two field seasons point out that the region was one of the preferred zones for the prehistoric communities since the Paleolithic periods. In addition to describing the archaeological sites identified, this article includes information about the ethnobotanical studies conducted as part of the project and a study of the routeways through the Bolkar Mountains in order to understand the interregional passages

Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity

Background. Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with unknown etiology. This report aims to present a case of LCH with diffuse involvement of the oral cavity and to raise awareness of the distinguishing features of this diagnostically challenging entity. Case Report. A 26-year-old male patient presented with complaints of teeth mobility, intense pain, and difficulty in chewing. Intraoral and radiological examinations revealed generalized gingival hyperplasia and severe teeth mobility with widespread alveolar bone loss. Periodontal therapy was performed with no significant improvement. An incisional biopsy revealed Langerhans cells and positive reaction to S-100 and CD1, and the patient was diagnosed with LCH. The patient underwent systemic chemotherapy with vinca alkaloids and corticosteroids. Regression of gingival lesions, as well as significant decrease in mobility of the remaining teeth and severity of pain, was achieved during 12 months of follow-up. Conclusion. The rarity and variable system involvement of LCH necessitate a multidisciplinary approach be carried out for accurate diagnosis, effective treatment, and an uneventful follow-up. Awareness of oral manifestations of LCH may aid clinicians greatly in reducing morbidity and mortality associated with this debilitating condition