ESTRO-ACROP guideline on surface guided radiation therapy

Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and highlights common challenges and potential errors. Comprehensive guidelines for procurement, acceptance, commissioning, and QA of SGRT systems installed on computed tomography (CT) simulators, C-arm linacs, closed-bore linacs, and particle therapy treatment systems are presented that will help move to a consensus among SGRT users and facilitate a safe and efficient implementation and clinical application of SGRT. Keywords: ACROP; ESTRO; Guideline; SGRT; Surface guided radiation therapy

Do I-Pass for FAIR?:A self-assessment tool to measure the FAIR-ness of an organization

The 15 FAIR data principles are intended to be applied to a dataset, but the acronym FAIR is also used as an adjective for other (digital) matters, such as FAIR data stewardship, FAIR data infrastructure and FAIR data services. Moreover, in the context of Open Science and scientific integrity, more and more Dutch universities and research organizations discuss a FAIR organization as an important goal, thus implementing RDM practices and support with the FAIR principles as a main driver. Triggered by this use of the acronym FAIR for organizations, an LCRDM (National Coordination Point Research Data Management) task group explored the definition, characteristics and principles of a so-called ‘FAIR enabling organization’. The task group delivered two products: (1) a definition for a FAIR enabling organization and (2) a self-assessment tool to evaluate the FAIR-ness of a research organization (research institute, university or university of applied sciences). This self-assessment tool is a simple instrument, presented in an editable PDF form. By answering the questions and evaluating the level (beginner, intermediate, or advanced) at which you assess the performance of your organization, you will be able to define the actual FAIR-ness. In addition you can define a Road Map to become a FAIR Enabling Research Organization using the information in de more advances level(s)

PET imaging of hypoxia using [F-18]HX4: a phase I trial

 Download the images using these instructions and this DOI : 10.1007/s00259-010-1437-x Background and purposeNon-invasive PET imaging of tumour hypoxia could help in the selection of those patients who could benefit from chemotherapy or radiation with specific antihypoxic treatments such as bioreductive drugs or hypoxic radiosensitizers. In this phase I trial, we aimed to determine the toxicity of [18F]HX4, a member of the 2-nitroimidazole family, at different dose levels. The secondary aim was to analyse image quality related to the HX4 dose and the timing of imaging.MethodsPatients with a..

A study of the leakage of the Antarctic polar vortex in late austral winter and spring using isentropic and 3-D trajectories

The permeability of the Antarctic polar vortex is investigated in late austral winter and spring by comparing isentropic and three-dimensional (3-D) trajectories. Trajectory computations were performed with the help of the Royal Dutch Meteorological Institute (KNMI) trajectory model, using data from the European Centre for Medium-Range Weather Forecasts (ECMWF) from August to November 1998. Large numbers of air parcels were initially released inside and outside the polar vortex on the 350, 450, and 550 K isentropic surfaces. They were integrated 4 months forward in time in an isentropic mode, as well as in a 3-D mode that uses all three wind components from the ECMWF and takes into account diabatic heating and cooling effects. For the isentropic trajectory calculations, very little transport (0.37%/week) was found for August and September, while October and November gave somewhat higher transport rates (1.95%/week). The 3-D trajectory calculations for October gave much more exchange between the vortex and midlatitudes than the isentropic ones owing to a significant number of parcels that descended inside the vortex. Descent rates were calculated for 350 K (October), 450 K (August–October) and 550 K (October). Overall, the results show that 3-D trajectories will provide more accurate leakage rates than the isentropic ones. Also, despite the large-scale mixing in the polar vortex or in midlatitudes, little ozone-depleted air leaks from the ozone hole into the midlatitude stratosphere

Recent advances in Surface Guided Radiation Therapy

The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. Although this technology is not new, many aspects of it have only recently been exploited. This review focuses on the latest SGRT developments, both in the field of general clinical applications and special techniques. SGRT has a wide range of applications, including patient positioning with real-time feedback, patient monitoring throughout the treatment fraction, and motion management (as beam-gating in free-breathing or deep-inspiration breath-hold). Special radiotherapy modalities such as accelerated partial breast irradiation, particle radiotherapy, and pediatrics are the most recent SGRT developments. The fact that SGRT is nowadays used at various body sites has resulted in the need to adapt SGRT workflows to each body site. Current SGRT applications range from traditional breast irradiation, to thoracic, abdominal, or pelvic tumor sites, and include intracranial localizations. Following the latest SGRT applications and their specifications/requirements, a stricter quality assurance program needs to be ensured. Recent publications highlight the need to adapt quality assurance to the radiotherapy equipment type, SGRT technology, anatomic treatment sites, and clinical workflows, which results in a complex and extensive set of tests. Moreover, this review gives an outlook on the leading research trends. In particular, the potential to use deformable surfaces as motion surrogates, to use SGRT to detect anatomical variations along the treatment course, and to help in the establishment of personalized patient treatment (optimized margins and motion management strategies) are increasingly important research topics. SGRT is also emerging in the field of patient safety and integrates measures to reduce common radiotherapeutic risk events (e.g. facial and treatment accessories recognition). This review covers the latest clinical practices of SGRT and provides an outlook on potential applications of this imaging technique. It is intended to provide guidance for new users during the implementation, while triggering experienced users to further explore SGRT applications

Is high-dose stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) overkill? A systematic review

AbstractBackground and purposeFor stereotactic body radiotherapy (SBRT), typically a scheme of 60Gy in 3–8 fractions is applied, producing local tumour control rates around 90%. The dose specification is in one point only and ignores possible underdosages at the edge of the planning target volume (PTV). We investigated the doses at the edge of the PTV and correlated this with local tumour control with the aim to shed light on the radiation dose needed to eradicate stage I NSCLC.Materials and methodsPublished data on the freedom from local progression (FFLP) data from SBRT and accelerated high-dose conventional radiotherapy series for stage I NSCLC with a follow up of at least 30months were included. The EQD2,T was calculated from the dose at the periphery of the PTV.ResultsFifteen studies for SBRT (1076 patients) showed a median FFLP of 88.0±10.4% with a median EQD2,T of 76.9±17.4Gy. The median FFLP was 87.6±6.0% for the accelerated schedules with an EQD2,T of 86.9±39.1Gy, respectively. No significant relation was found between FFLP and the EQD2,T (p=0.23).ConclusionsSeveral fractionated and accelerated schedules with equal biological doses achieve the same tumour control rates as SBRT. Lower, but more uniform doses to the whole PTV may be sufficient to achieve similar control rates, with the possibility to deliver SBRT in adapted schedules, beneficial to centrally located tumours in the vicinity of critical structures like the oesophagus and great vessels