Treatment of childhood relapsed hodgkin lymphoma

WOS: 000384818801128

Is There Increased Risk of Childhood Cancers after Assisted Reproductive Techniques?

Background and Aims: Assisted reproductive techniques (ART) havebeen determined to be a risk factors for multiple pregnancy, perinatalcomplications and congenital malformations in children. In this study,we aimed to determine the role of possible risk factors for assistedreproductive techniques in childhood malignancies.Methods: 300 patients between the ages of 0-18 years who wereadmitted to Istanbul Medical Faculty, Department of Pediatric Hema-tology and Oncology, between 2000-2019 and 300 healthy childrenbetween 0-14 years of age who were admitted to Departmens of SocialPediatrics, period of May-June 2018 are included. SPSS 22.0 program was used in statistical analysis. The study was approved by the ClinicalResearch Ethics Committee (17.05.2018 / 181360).Results: The mean age of the case group was 8.3±2.1, control groupwas 6.1±1.2 years. The case group consisted of 131 solid tumors and169 leukemia-lymphoma. 17 of 300 patients in the case group wereborn ART, 21 of 300 patients in the control group were born after ART,there was no statistically significant difference (p = 0.12). Five (6.8%)of the 73 ALL patients in the case group, two of the 38 NBL patients(5.2%), one of 10 germ cell tumors (10%), one of 26 NHL (3.8%), oneof 50 HL (2%), one of 15 RMS (6.6%), two of 17 LCH (11.7%), one of 19wilms tumors (5.2%), one of 8 hepatoblastomas (12,5%) were born withART. The patient who was diagnosed with infantile hemangioendothe-lioma and congenital mesoblastic nephroma in the study were born asaresultofART.Conclusions: Our results did not support retrospectively as a possi-ble risk factor of birth as a result of fertility treatment in children withcancer. The rates of developing tumors in children with healthy donorsused in infertile families will also contribute to the questions betweenART and childhood tumors in the futur