33 research outputs found
Drug-Induced Acneiform Eruptions
Acne vulgaris is a chronic skin disease that develops as a result of inflammation of the pilosebaceous unit and its clinical course is accompanied by comedones, papules, pustules, and nodules. A different group of disease, which is clinically similar to acne vulgaris but with a different etiopathogenesis, is called “acneiform eruptions.” In clinical practice, acneiform eruptions are generally the answer of the question “What is it if it is not an acne?” Although there are many subgroups of acneiform eruptions, drugs are common cause of acneiform eruptions, and this clinical picture is called “drug-induced acneiform eruptions.” There are many drugs related to drug-induced acneiform eruptions. Discontinuation of the responsible drug is generally sufficient in treatment
Evaluation of ocular findings in patients with lichen planus
WOS: 000472026600004PubMed: 31333342Introduction: Lichen planus (LP) is a chronic, inflammatory disease of unknown etiology. Aim: To evaluate the tear functions and the retinal and choroidal thickness (CT) in patients with LP. Material and methods: In total, 33 patients and 30 healthy controls were enrolled. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer 1 test (with anesthesia), tear break-up time (TBUT) test, intraocular pressure (IOP), axial length (AL), and central corneal thickness (CCT). The measurements of retinal thickness (RT) and CT were obtained by spectral domain optical coherence tomography. Results: No significant difference was observed between the groups in IOP, AL, CCT, or RT (p > 0.05 in each group). There was a significant difference in the Schirmer 1 test, TBUT, and OSDI questionnaire (p < 0.05 in each group). Choroidal thickness in LP patients was thinner than that in the controls (p = 0.001 in each location). There was a moderate negative correlation between the disease duration and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.426, r = -0.555, r = -0.637; p = 0.001, p = 0.001, p = 0.001, respectively). There was a moderate negative correlation between the oral mucosal involvement and Schirmer 1 test, TBUT, and subfoveal CT (r = -0.345, r = -0.392, r = -0.467; p = 0.006, p = 0.001, p = 0.001, respectively). There was a positive correlation between disease duration, oral mucosal involvement and OSDI score (r = 0.717, r = 0.345; p = 0.001, p = 0.006, respectively). Conclusions: Lichen planus may influence tear function tests and may cause dry eye. Patients with LP had lower CT values than healthy controls. Further studies are needed to clarify the effect of LP on the eyes
The Significance of Scars: Patient and Clinician Perspectives
The formation of a scar represents the extension of regenerative wound repair mechanisms. On the one hand, scar tissue helps in wound closure by supporting wound contracture and reepithelization. There is no doubt that the scar formation developed in response to an injury facilitates the organism’s survival process directly and effectively. On the other hand, the effect of the pathologically developed scarring on the global disease burden has still not been accurately defined. There are three basic subtypes of scars, namely simple, atrophic, and hypertrophic/pathological (hypertrophic scars and keloids), and they have different histopathological features, development, dispersion patterns, and remission phases. There are important consequences when scars’ global and individual effects are considered. Patients with scars face long-term functional and psychological problems. In interpreting scars for both individuals and society, individual, cultural, psychological, and social effects and prejudices play a crucial role. Both the psychosocial and financial aspects of the scars, as well as the effects on the patient and society, should be considered. © 2019 by Nova Science Publishers, Inc
Behçet disease: New developments in the etiopathogenesis of an old silk road disease
PubMed ID: 29989537Behçet disease (BD) is a systemic inflammatory disorder that affects the skin, mucosa, eyes, joints, blood vessels, brain, and gastrointestinal tract. The etiopathogenesis of BD has not yet been fully elucidated, but disorganized immune responses against the stimuli of environmental triggering factors have been considered to play a major role in the pathogenesis of the disease in individuals with genetic susceptibility. Human leukocyte antigen (HLA)-B*51 is known to be the main factor involved in genetic susceptibility to BD. Among the environmental factors, infectious agents in particular are thought to be important. Immunological abnormalities could thus be the cornerstone in the development of BD. Along with cytokines that play a role in disease pathogenesis, numerous other cytokines have been recently identified or have been the focus of recent studies. This contribution sheds light on the etiopathogenesis and immunology of BD in relation to the current literature. © 2018 Pulse Marketing & Communications, LLC
Cutaneous manifestations of diabetes mellitus and the metabolic syndrome
WOS: 000419087300014PubMed: 29241758Metabolic diseases are commonly encountered in the Western world. Cutaneous manifestations are common in metabolic disorders, such as diabetes mellitus (DM) and the metabolic syndrome (MetS), and metabolic diseases may manifest with specific skin findings. MetS and DM share a common mechanism in their etiopathogenesis. As a result, the skin findings associated with these two diseases partially overlap. Several skin findings in DM and MetS may be the first clinical features of the disease, and early diagnosis facilitates treatment, thereby helping in preventing long-term complications. In this review, MetS and skin manifestations associated with DM are discussed. (C) 2018 Elsevier Inc. All rights reserved
Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris
Ertas, Ragip/0000-0002-9269-2619WOS: 000430876600011Objective: We aimed to investigate the effect of isotretinoin treatment on sleep and quality of life in patients with AV. Methods: 109 total patients who identified as 66 AV patients attended the dermatology outpatient clinic and started isotretinoin treatment, and 43 healthy controls, were enrolled in the study. Pittsburgh Sleep Quality Index (PSQI), short form-36 (SF-36), and Global Acne Grading System (GAGS) were administered to all patients twice; before and two months after the treatment. The results were compared with the healthy control group. Results: The pretreatment physical health scores of the patients were significantly higher than the healthy controls. No significant differences were observed between before-after isotretinoin treatment regarding physical and mental health scores in AV patients. While there were no significant differences between the pretreatment and healthy control group in terms of total PSQI scores; the scores of sleep duration were significantly lower in the pretreatment group. No significant differences were observed between before-after isotretinoin treatment regarding total PSQI and subcomponent scores in AV patients. There was a statistically significant negative correlation between pre- and post-treatment total PSQI scores and physical, mental health scores in patients with AV. Conclusion: Results of the present study suggest that isotretinoin therapy does not affect the sleep quality in patients with AV. The impairment of sleep quality negatively affects the quality of life in patients with AV. More comprehensive studies assessing the effect of isotretinoin treatment on sleep quality are needed
Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study
Uzuncakmak, Tugba Kevser Ustunbas/0000-0001-8057-3463WOS: 000434665900005PubMed: 30374476OBJECTIVE: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group. METHODS: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. The number of diabetic obese patients was 138 (30%), whereas that of nondiabetic obese patients was 312 (70%). A detailed dermatological examination was performed for each case, and accompanying dermatoses were compared. RESULTS: The mean body mass index (BMI) in the obese patients and control group was 37.22 kg/m(2) and 22.23 kg/m(2), respectively. The most common dermatoses in the obese patients were, according to their frequency: striae distensae (291 patients, 64.7%), acrochordon (236 patients, 52.4%), acanthosis nigricans (213 patients, 47.3%), plantar hyperkeratosis (209 patients, 46.4%), and venous insufficiency (202 patients, 44.9%). Although hirsutism was more frequently observed in the nondiabetic obese group than in the diabetic obese group, stasis dermatitis was less frequently observed (p<0.05). CONCLUSION: We found that many dermatoses are more frequently observed in the obese patients than in the controls. We observed that the effect of obesity on skin is different from that of diabetes mellitus and that cutaneous manifestations of obesity occur more frequently. More extensive, comprehensive, and advanced studies on this subject are required
Endothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertility
WOS: 000332502000004PubMed: 24504178Background/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, Base
Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey
WOS: 000519592400024Introduction: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. Aim: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. Material and methods: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. Results: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 +/- 2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 +/- 1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis
Results of Skin Prick Tests in Dermatology Outpatient Allergy Unit
WOS: 000518456300009Amaç: Deri prick testi (DPT) başlıca atopik dermatit (AD), kronik ürtiker (KÜ),
alerjik astma (AA), ve alerjik rinit (AR) gibi hastalıkların tanı ve takibinde
kullanılmaktadır. Bu çalışmanın amacı, Dermatoloji Kliniği Alerji Ünitesi
(DKAÜ)'nde yapılan DPT sonuçlarının geriye dönük olarak incelenerek,
endikasyonları ve pozitiflik oranlarının araştırılmasıdır.
Gereç ve Yöntem: DKAÜ arşivi kullanılarak 2014-2016 yıllarında yapılan DPT
sonuçları incelenmiştir. DPT sonuçları, her hasta için ayrıca arşivlenen DPT formları
okunarak yapılmıştır.
Bulgular: DKAÜ'nde 2014-2016 yılları arasında 1916 hastaya DPT yapılmıştır. Bu
hastaların 941'inde AA, 133'ünde AR, 842'sinde dermatolojik hastalık olduğu
görülmüştür. En az bir ve birden fazla alerjen madde ile DPT pozitiflik oranı, sırasıyla
AA, AR ve dermatolojik hastalıklarda; %92.1, %71.4 ve %50 olarak saptanmıştır.
Dermatolojik hastalıklar incelendiğinde, 69 kronik ürtiker (KÜ), 55 atopik dermatit
(AD) hastası haricinde, geriye kalan 718 hastada, başlıca dermatit, idiopatik
generalize pruritus (İGP) olmak üzere farklı dermatolojik hastalıkların olduğu
görülmüştür. DPT pozitifliği KÜ’de %55.1, AD’te %52.7 ve diğer dermatolojik
hastalıklarda %48.6 olarak saptanmıştır.
Sonuç: Bu çalışmanın sonuçlarına göre DPT pozitiflik oranı, AR ve AA hastalarında
hem KÜ ve AD hem de diğer dermatolojik hastalıklara göre daha yüksektir. Bunun
nedeni, KÜ ve AD etyopatogenezinde tip 1 aşırı duyarlılık reaksiyonlarının rolünün
daha az olması ve/veya farklı dermatolojik tanılarla yönlendirilen hastalarda doğru
olmayan DPT endikasyonları olabilirObjective: Skin prick test (SPT) is mainly used for diagnosis and follow-up of
diseases like atopic dermatitis (AD), chronic urticaria (CU), allergic asthma (AA) and
allegic rhinitis (AR). The aim of current study is to explore the results of SPT
retrospectively which were performed in Dermatology Outpatient Allergy Unit
(DOAU) for identifying indications and positivity.
Methods: Results of SPT which were performed on 2014-2016 were investigated
based on archives of DOAU. Results of SPT were analyzed from the SPT Forms
which were prepared for each patient.
Results: SPT were performed on 1916 individuals who admitted to DOAU during
2015-2016. AA was determined in 941, AR in 133 and dermatological diseases were
842 patients. SPT positive results, for at least one or more allergen agents, of patients
with AA, AR and dermatological diseases were 92.1%, 71.4% and 50% respectively.
Dermatological diseases included; except CU in 69 patients and AD in 55 patients. In
the remaining 718 patients were diagnosed with dermatitis, idiopathic generalised
pruritus (IGP) and other dermatological disorders. SPT positivity rates in CU was
55.1%, 52.7% in AD and 48.6% in several dermatological diseases.
Conclusions: As a result, the rate of SPT positivity in patients with AA and AR were
higher than both CU, AD and several dermatological diseases. The reason of this may
be related with lesser role of type 1 hypersensivity reaction in etiopathogenesis of CU
and AD, and/or improper SPT indications who were directed with diagnosis of several
dermatological diseases