Hepatocellular carcinomas with granulomatous inflammation in tumor stroma: Clinicopathologic characteristics

Objective: To determine the frequency of granulomatous inflammation within hepatocellular carcinoma (HCC) and its clinicopathologic associations. Material and Method: Fifty-eight HCCs (51 explants, 3 lobectomies, and 4 segmentectomies) were reviewed. Results: Five (8.6%) cases (F/M=1/4, mean age: 63.6) were identified with granulomas.1/5 had history of neoadjuvant therapy. 4/5 patients presented with early stage (pT1/2). All were well-differentiated (Grade1-2/4). The mean number of tumor foci was 3.6, with a median size of 2.2 cm. All of them had advanced fibrosis. No difference was identified from cases without granulomas (n=53) in terms of prognosis and aforementioned parameters (p> 0.05). Granulomas were mainly concentrated in peripheral parts of the tumors. One case with nodule-in-nodule formation had granulomas lined along the border of the inner nodule. In 2 cases, granulomas were identified in steatohepatitic areas, while another had clear cell change. Only 1 had necrotizing granulomas, none with acid resistant bacilli. Two cases revealed concomitant granulomas in the adjacent liver parenchyma in addition to the tumor stroma. Except for one with a history of tuberculosis, none of the cases had a granulomatous disease. Conclusion: This is the largest case series of HCCs with granulomas by far. Our data revealed neither clinicopathologic and prognostic difference nor definite etiology related to granulomas. Yet, association with steatotic and clear tumor cells suggests the role of cytoplasmic content, while distribution of granulomas points to host immune response

Random rescreening 10% of negative cervicovaginal smears: Method for quality assurance

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Primary leiomyosarcoma of the stomach: A case report

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The effect of cultural factors and consumer knowledge on fish consumption

Fish is an important part of a healthy diet. Fish and seafood products are recommended to take a prominent position in the human diet thanks to their beneficial effect on the prevention of chronic degenerative diseases. The consumption of fish may be protective against cancers and cardiovascular diseases. Therefore, health authorities and the food industry have a joint interest in stimulating fish consumption

Biosafety in Aquaculture Using Biotechnology

AbstractAquaculture sustainability depends on three pillars, environment, financial and social. The stability of environmental conditions ensures safe production without drawbacks. Yet, aquatic environment tends to change constantly carrying many hazards for aquaculture production. Enviguard system was designed to monitor these environmental threats in real time using biotechnology to provide fish farmers a platform as a biosecurity measure and ensure unhindered production. Enviguard system was developed as a highly specific and precise in situ measurement device to monitor and measure man-made chemical contaminants and biohazards before reaching the farming sites. Different farming sites with variety of species in production were evaluated to establish a modular system with different sensors covering the needs of the farmers. The system was designed to work automatically in the marine environment with remote date sharing. Enviguard system provides early detection of pathogens and man-made pollutants which will prevent future damages of the marine environment to the sustainability of the aquaculture production and supply of healthy, high quality seafood ensuring food safety. Keywords: Enviguard, real time monitoring, sustainability, Fish farming Acknowledgement: This work was supported by European Union 7th Frame Work Programme for Research, Technological Development, Project number: 61405