Evaluation of the efficacy of pro-yellow laser in the management of vascular skin disorders

Background: Lasers have great importance in the management of vascular skin lesions. Aim: To determine the efficacy of 577-nm pro-yellow laser in cure of certain vascular skin diseases. Material and methods: Seventy-four patients who are diagnosed as vascular skin diseases were involved in this study. All participants were treated with 577-nm pro yellow laser with 4-week intervals. The photographs that were taken before and at every following visit were used to evaluate improvement. Results: A significant improvement occurred in port-wine stain, rosacea, facial telangi ectasia, venous lake, scrotal angiokeratoma, and cherry angioma cases. Conclusion: Vascular skin lesions can be treated with 577-nm pro-yellow laser with a minimal adverse effect and great success rate

An alternative for the treatment of vulvar syringoma: 577 nm pro-yellow laser

Background: Syringoma is a benign sweat gland tumor. Aim: Vulvar location of syringoma is rare. Although the lesions are asymptomatic, it requires treatment due to the cosmetic concerns. Patients/Methods: We present a 42-year-old woman with vulvar syringoma. Results: The patient treated with 577 nm pro-yellow laser with a great success. Conclusion: A 577 nm pro-yellow laser is a good alternative in the treatment of vulvar syringoma

A Prediction Study about the Pandemic Era based on Machine Learning Methods

Coronavirus pandemic has been going on since late 2019, millions of people died worldwide, vaccination has recently started in many countries and new strategies are sought by countries since they are still struggling to defeat the virus. So, this research is made to predict the possible ending time of the coronavirus pandemic  in Turkey using data mining and statistical studies. Data mining is a computer science study that processes large amounts of data and produces new useful information. It is especially used to support decision making in companies today. So, this project could support the decision making of authorities in developing an effective strategy against the on-going pandemic. During the research we have practiced on Turkey’s coronavirus and vaccination data between 13 January 2021 and  28 May 2021. We used Rapidminer and the Random Forest method for data mining. After all the simulations we have applied and observed during our research, it was clearly seen that vaccination parameters were decreasing the new cases. Also, the stringency index did not affect the new cases. As a conclusion of our research and observations, we think that the government should vaccinate as many people as it can in order to relax restrictions for the last time

Comparison of the efficacy of broad-band targeted UVB phototherapy and topical psoralen with targeted UVA phototherapy in localized vitiligo

Aim of the study is to compare efficacy of targeted broad-band UVB phototherapy and topical psoralen with targeted UVA phototherapy treatments in localized vitiligo for 3 months prospectively. The cases with symmetrical vitiligo lesions were included in the study. Broad-band targeted UVB was applied on one side and targeted UVA phototherapy with topical psoralen on the other side. Twenty-two patients who were diagnosed with localized vitiligo were enrolled in this study. These cases consisted of 6 (27.3%) females and 16 (72.7%) males aging between 17 and 69 (34.22 ± 14.15). Fifty-four lesions (27 left, 27 right) were compared for treatments. After the first month of the treatments, the sides of the lesions were compared in order to evaluate improvement. Percentages of success were 25% for targeted broad-band UVB microphototherapy and 75% for topical psoralen with targeted UVA microphototherapy. When the two treatment methods were com pared with each other, a significant difference was found in terms of treatment response (P = .017). At the end of the third month, the success rates were 37.5% for targeted broad-band UVB microphototherapy and 62.5% for topical psoralen with targeted UVA microphototherapy, however a statistically significant differ ence was not determined between the two treatments (P > .05). Both targeted broad-band UVB phototherapy and topical psoralen with targeted UVA phototherapy provided repigmentation for localized vitiligo at the end of the third month. Our investigation shows that both treatments are safe and they provide repigmentation with a limited response

Cellulose acetate encapsulated upconversion nanoparticles – a novel theranostic platform

Luminescent upconversion nanoparticles (UCNPs) are of great interest in a wide range of nanotechnological applications, particularly in the biomedical area like imaging and therapy but their biocompatibility and stability pose major challenges hampering progression towards further pharmaceutical applications. Herein, we present a biocompatible theranostic platform enabling simultaneous diagnosis and drug delivery consisting of UCNPs encapsulated with cellulose acetate (CA), a biocompatible polymer. Luminescence properties of UCNPs in the developed theranostic platform remain stable even after encapsulation. The size of the CA capsules, ranging from micro- to nano-sized particles, can easily be tuned by adjusting the stirring rate during encapsulation. Doxorubicin, a well-known chemotherapeutic drug, onto the CA nanocapsules containing UCNPs (UCNP-CA nanocapsules) was loaded with up to ~63 % efficiency and acid-induced release (~47 %) obtained at pH 3.6 and 5.5. It was found that encapsulation decreased toxicity of UCNPs as confirmed in a cellular assay (L-929 and MCF-7 cell lines). Taken together, the developed UCNP-CA nanocapsules serve as a highly interesting novel theranostic platform, combining the biocompatible optical properties of UCNP, with reduced cell toxicity and drug encapsulating properties of CA. The proposed system could be subject for further refinement and exploration.No sponso

An Angiomatous Antrochoanal Polyp with Epistaxis and Bony Destruction

Angiomatous polyps are rare sinonasal masses and may present with intense epistaxis. Angiomatous antrochoanal polyps are rare variants of antrochoanal polyps, and their diagnosis and management requires more detailed evaluation in respect to classical antrochoanal polyps. In both antrochoanal polyps and angiomatous polyps, bone destruction is an exceptional finding. The signs of bone destruction and epistaxis suggest additional pathologies including inverted papilloma, lobular capillary haemangioma and carcinoma as differential diagnoses. In this case, total excision of a left-sided angiomatous antrochoanal polyp with bone destruction was managed with nasal endoscopic approach. Troublesome intraoperative bleeding was avoided with effective additional measures

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) in a Rat Endometriosis Model

Objective: We aimed to investigate the effect of platelet‑rich plasma (PRP) derivatives, which can be produced from the patient’s blood and have minimal side effects, on endometriosis.Methods: To our knowledge, this is the first study in the literature that studies the relationship between PRP and endometriosis. Endometriosis foci were created in the first operation. In the second operation (30th day), four groups were formed wherein group 1 (n = 8) was administered saline, group 2 (n = 7) leukocyte and platelet‑rich plasma (L‑PRP), group 3 (n = 8) pure platelet‑rich plasma (P‑PRP) and group 4 (n = 10) was used to obtain PRP. In the last operation (60th day), the endometriotic foci was measured and then excised.Findings: There was no statistically significant difference between the pre and post volumes of the endometriotic foci, between their volume differences, and volume difference rates (P > 0.05). However, it was observed that existing implant volumes in all groups decreased statistically significantly within their groups by the end of the experiment compared to the previous volumes (P < 0.05).Conclusion: When the implants were assessed through histopathological scoring in terms of edema, vascular congestion, inflammatory cell  infiltration, hemorrhage, epithelial line, and hemosiderin accumulation, and immunohistochemical staining was assessed in terms of VEGF, there was no significant difference in the comparison between the groups. Although L‑PRP and P‑PRP generated more reduction in the endometriosis foci, they did not create any statistical differences. Key words: L‑Prp; P‑Prp; VEGF; endometriosis