Modified Tapvei OÜ Stairs Induce an Anxiolytic Effect in Female C57BL/6 Mice in the Elevated Plus-Maze Test

We evaluated the effect of modified Tapvei OÜ stairs (stairs) on the behaviour of female C57BL/6 and BALB/c mice in the elevated plus-maze (EPM) test. The mice were kept under standard conditions for 4 weeks (control) or exposed to stairs for 3 or 4 weeks, and were assessed thereafter with the EPM. The C57BL/6 mice displayed less anxiety, when compared with the BALB/c mice. Exposure to stairs had an anxiolytic effect in C57BL/6 mice, but not in BALB/c. The strain-dependent effects of stairs should be considered in the design of housing refinements and behavioural experiments