4 research outputs found
Purpuric pityriasis rosea
Pityriasis rosea (PR) is a common self-limited exanthem of unknown
cause. The typical presentation of PR is easily recognized. Since
purpuric PR is a very rarely seen variant, its diagnosis is sometimes
difficult. In our 16-year-old female patient, maculopapular eruptions
were healed spontaneously after one month. Erythrocyte extravasation in
the dermis was observed in the histopathologic examination
Serum Paraoxonase And Arylesterase Activities In Esophageal Cancer: A Controlled Study
Aim: Upper gastrointestinal tract carcinomas are major health problem
around the world. Esophageal cancer (EC) is usually diagnosed at an
advanced stage; therefore most therapeutic approaches are palliative.
The aim of the study was to investigate the possible relationship
between serum activities of paraoxonase (PON1) and arylesterase (ARE),
and clinicopathological characteristics in EC. Method: Forty patients
with EC and twenty seven healthy subjects were included in the study.
The diagnosis of esophageal cancer was established by endoscopic
examination of the esophagus and by biopsy confirmation. PON and ARE
activities were determined by or with spectrophotometrically using
paraoxon and phenyl acetate as substrates, respectively. Mann
-Whitney-U test was used for statistical analysis. Result: The mean
serum PON and ARE activities were significantly higher in the cancer
group compared to healthy controls. Besides, mean values of serum PON
and ARE activities decreased in stage 3 and stage 4 EC patients
compared with stage 2 EC patients. This decrease was statistically
significant. There were no statistically correlation between other
clinicopathological characteristics and serum PON and ARE activities in
this EC patient group. Conclusion: This is the first report on serum
PON and ARE activities in patients with EC. Our results indicate that
low serum PON and ARE activities may be an important indicator for
advanced stage in EC. But these preliminary results need to be verified
by further prospective studies for the early diagnosis of the tumor,
for the detection of clinical relapse and for the monitoring of follow
up treatment