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Pulmonary lymphoid lesions in an experimental model of collapsing glomerulopathy in rats
The characterization of lung damage in an
experimental model of collapsing glomerulopathy (CG)
in rats is described. Methods: 12 rats were divided into
two groups and injected intravenously (iv) with 1 mg/
saline in a final volume of 1 ml/ day in the tail vein for 5
days, with fractionated serum from control and CG
subjects. Proteinuria was quantified, and the Glomerular
filtration rate was calculated based on creatinine
clearance (CC). Rats were sacrificed by perfusion
fixation at day 5. Results: Rats injected with serum from
CG patients developed proteinuria (p<0.001). A decrease
in CC (0.68±0.19) in these rats was also observed.
Glomerular tuft retraction and mesangial proliferation
was observed in all rats receiving serum from the CG
patients. Peribronchiolar infiltrate integrated mainly by
lymphocytes, was identified in all CG rats. In some areas
this infiltration disrupted the basement membrane and
damaged the epithelium. No histopathological
abnormalities in the kidney or lungs were found in rats
receiving control serum. Conclusion: Patchy pulmonary
lymphoid infiltrates were found in the CG model. Up to
now there was no information about pulmonary
lymphoid infiltration in CG patients. Besides fluid
overload due to renal insufficiency or a nephrotic
syndrome, other causes of pulmonary involvement in
CG patients should be explored