2 research outputs found

    Prolapso de la válvula mitral, una revisión bibliográfica

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    Debido a la prevalencia del prolapso de la válvula mitral (PVM) en la población y la diversidad de criterios acerca de ella, se realizó una revisión bibliográfica con el objetivo de caracterizar el prolapso de la válvula mitral, donde se analizaron 30 referencias bibliográficas. La distribución del PVM respecto al sexo, aunque es cuestionada, parece afectar con mayor severidad a los hombres. Esta enfermedad ha sido considerada como una de las valvulopatía benignas más frecuentes en la edad pediátrica. Existe un subgrupo de pacientes con peor pronóstico, fundamentalmente aquellos en los que el PVM se acompaña de válvulas muy afectadas. En pacientes asintomáticos se aconseja realizar un seguimiento clínico-ecocardiográfico que permita estratificar el riesgo de complicaciones. ABSTRACTBecause of the prevalence of mitral valve prolapse in the population and the diversity of views about it, a literature review was conducted with the aim of characterizing the mitral valve prolapse, where 30 references were analyzed. PVM distribution regarding sex, although it is questioned, seems to affect more severely men. This disease has been considered one of the most frequent benign valve disease in children. There is a subgroup of patients with worse prognosis, mainly those in which the PVM is accompanied by very affected valves. In asymptomatic patients are advised to conduct a clinical-echocardiographic follow-up that allows stratify the risk of complications

    POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation

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    Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors cells has been well-known for almost a century, but specific factors that regulate lactate generation and the effects of lactate in both cancer cells and stroma are not yet well understood. In the present study using breast cancer cell lines, human primary cultures of breast tumors, and immune deficient murine models, we demonstrate that the POU1F1 transcription factor is functionally and clinically related to both metabolic reprogramming in breast cancer cells and fibroblasts activation. Mechanistically, we demonstrate that POU1F1 transcriptionally regulates the lactate dehydrogenase A (LDHA) gene. LDHA catalyzes pyruvate into lactate instead of leading into the tricarboxylic acid cycle. Lactate increases breast cancer cell proliferation, migration, and invasion. In addition, it activates normal-associated fibroblasts (NAFs) into cancer-associated fibroblasts (CAFs). Conversely, LDHA knockdown in breast cancer cells that overexpress POU1F1 decreases tumor volume and [18F]FDG uptake in tumor xenografts of mice. Clinically, POU1F1 and LDHA expression correlate with relapse- and metastasis-free survival. Our data indicate that POU1F1 induces a metabolic reprogramming through LDHA regulation in human breast tumor cells, modifying the phenotype of both cancer cells and fibroblasts to promote cancer progressionThis study was supported by FEDER/Ministerio de Ciencia, Innovación y Universidades- Agencia Estatal de Investigación-PGC2018-100776-B-I00 and from Conselleria de Cultura, Educación e Ordenacion Universitaria (GPC2014/001), AM-O was supported by an FPU grant (Ministerio de Educación—FPU14/00548)S
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