Treatment of Primary Nummular Headache: A Series of 183 Patients from the NUMITOR Study

Nummular headache (NH) is a primary headache characterized by superficial coin-shaped pain. NUMITOR (NCT 05475769) is an observational study evaluating the responder rate of preventive drugs in NH patients. The treatment response was assessed between weeks 8 and 12 compared with the baseline. Patients were included between February 2002 and October 2022. Demographic and clinical variables were assessed; treatment response was estimated by 50%, 30%, and 75% responder rates and treatment discontinuation due to inadequate tolerability. A total of 183 out of 282 patients fulfilled eligibility criteria and completed the study. Patients were aged 49.5 (standard deviation (SD): 16.8) years, and 60.7% were female. NH phenotype was a parietal circular pain of four centimeters’ diameter, moderate intensity, and oppressive quality. At baseline, patients had 25 (interquartile range) pain days per month. Preventive treatment was used by 114 (62.3%) patients. The highest 50% and 75% responder rates corresponded to onabotulinumtoxinA (62.5%, 47.5%), followed by gabapentin (43.7%, 35.2%). Oral preventive drugs were not tolerated by 12.9–25%. The present study provides class IV evidence of the effectiveness of oral preventive drugs and onabotulinumtoxinA in the treatment of primary NH. OnabotulinumtoxinA was the most effective and best-tolerated drug, positioning it as first-line treatment of NH

sj-pdf-1-cep-10.1177_03331024231201576 - Supplemental material for Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up

Supplemental material, sj-pdf-1-cep-10.1177_03331024231201576 for Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up by Cristina García-Iglesias, Ana González-Celestino, Álvaro Sierra Mencía, Yésica González Osorio, Andrea Recio García, Cristina Martínez-Badillo, Ana Echavarría Íñiguez, Berta Varona-Galán, David García-Azorín Ángel Luis Guerrero-Peral in Cephalalgia</p

Additional file 1 of Factors associated to the presence of headache in patients with influenza infection and its consequences: a 2010–2020 surveillance-based study

Additional file 1: Supplementary table 1. Surveyed population per age-group. Supplementary table 2. Number of cases per season during the entire study period