83 research outputs found
ACE Inhibition and Endothelial Function: Main Findings of PERFECT, a Sub-Study of the EUROPA Trial
Background: ACE inhibition results in secondary prevention of coronary artery disease (CAD) through different mechanisms including improvement of endothelial dysfunction. The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction.
Methods: PERFECT is a 3-year double blind randomised placebo controlled trial to determine the effect of perindopril 8 mg once daily on brachial artery endothelial function in patients with stable CAD without clinical heart failure. Endothelial function in response to ischaemia was assessed using ultrasound. Primary endpoint was difference in flow-mediated vasodilatation (FMD) assessed at 36 months.
Results: In 20 centers, 333 patients randomly received perindopril or matching placebo. Ischemia-induced FMD was 2.7% (SD 2.6). In the perindopril group FMD went from 2.6% at baseline to 3.3% at 36 months and in the placebo group from 2.8 to 3.0%. Change in FMD after 36 month treatment was 0.55% (95% confidence interval ā0.36, 1.47; pā=ā0.23) higher in perindopril than in placebo group. The rate of change in FMD per 6 months was 0.14% (SE 0.05, pā=ā0.02) in perindopril and 0.02% (SE 0.05, pā=ā0.74) in placebo group (0.12% difference in rate of change pā=ā0.07).
Conclusion: Perindopril resulted in a modest, albeit not statistically significant, improvement in FMD
"Some Observations on the Evaporation of Water from Cellulose," TEXTILE RESEARCH JOURNAL 22: 2, 75-81 (1952)
THE TECHNOLOGY OF MAN-MADE ALGAL CRUST AND ITS APPLICATIONS IN CONTROL OF DESERTIFICATION
Before Evelyn: trees, tree planting and tree management in sixteenth- and early seventeenth-century England
Have Disfluency-Type Measures Contributed to the Understanding and Treatment of Developmental Stuttering?
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