Uji Efektivitas Ekstrak Lidah Buaya (Aloe Vera L.) Terhadap Penurunan Kolesterol Total Pada Tikus (Rattus Norvegicus) Putih Jantan Hiperkolesterolemia

Coronary heart disease is one of the biggest causes of death. Coronary heart disease is caused by the buildup of cholesterol in blood vessels. Aloe vera (Aloe vera L.) has many benefit on which one of them can lower blood cholesterol levels. The purpose of this study is to study the effective dose of aloe vera extracts (Aloe vera L.) which decreases rat (Rattus norvegicus) blood cholesterol level. The method used in this research was an experimental research with pre and post test method and control group design. Aloe vera extracts (Aloe vera L.) used was obtained through maceration method. Aloe vera extracts (Aloe vera L.) was extracted using ethanol 70%. Doses of aloe vera extract used were 0,3 gr/200 grBW, 0,6 gr/200 grBW, 1,2 gr/200 grBW. The positive control used in this study was cholestyramine. The rats were divided into 5 treatment groups, namely the positive control group given cholestyramine, the aquadest negative group, the first treatment group with the first dose, the second treatment group with the second dose, and the third treatment group with the third dose. Based on the result normality and homogenity test results indicate that the data distribution is normal and homogeneous. Statistical test results using one way ANOVA obtained p <0,05, means there are significant differences between each group. LSD test results showed significant differences between groups with different test times. It can be concluded that Aloe vera L. extracts could decrease total blood cholesterol level in white hypercholesterolemic male rat (Rattus norvegicus)

Hubungan Kadar Glukosa Darah Puasa dan Hba1c dengan Terjadinya ISK pada Penderita DM Tipe 2.

The prevalence of diabetes has increased worldwide. Diabetic mellitus patients with high blood glucose levels that are more susceptible to various infections, including urinary tract infections compared with patients who did not suffer from diabetes mellitus. To determine the association between fasting blood glucose levels and levels HbA1c with urinary tract infections in patients with type 2 diabetic mellitus. This study used a case-control study design and carried out at Hospital Dr. Moewardi Surakarta. The number of samples in this study were 48 samples taken with the technique purposive sampling. Data collection was performed by reading the medical records of patients with diabetes mellitus in June to the month of December 2018. The data were analyzed using chi-square test. Results of the chi square test showed no significant correlation between levels of fasting blood glucose with the occurrence of urinary tract infection (p = 0.383). and the value of OR 1.667. There is a significant correlation between the levels HbA1c with the occurrence of urinary tract infection (p = 0.035). and the value of OR 3.800

Uji Aktivitas Ekstrak Etanol 70% Rimpang kencur (Kaempferia galanga L.) Terhadap Staphylococcus epidermidis

Staphylococcus epidermidis is a group of negative coagulase staphylococcus which is a normal flora and can cause infection, often associated with implantable devices such as joint prosthetics, intravascular catheters. Inappropriate or irrational use of antibiotics for unnecessary diseases and the tendency for antibiotics to be bought free or without a prescription result in the development of antibiotic-resistant bacteria. Kencur (Kaempferia galanga L) is one of the herbal plants, active substances such as alkaloids, steroids, flavonoids and saponins contained in kencur rhizome extract has antibacterial activity. To determine the antibacterial activity of 70% ethanol extract of kencur rhizome (Kaempferia galanga L.) to Staphylococcus epidermidis. This research is an experimental laboratory research that is giving treatment of 70% ethanol extract of kencur rhizome (Kaempferia galanga L.) to Staphylococcus epidermidis bacteria by post test only controlled group design method. The kencur rhizome extract was divided into several concentrations, namely 20%, 40%, 60% and 80, On the muller hilton media that had been smeared with bacteria made a 6 mm diameter well. Wells are drippedthe rhizome extract in various concentrations. Furthermore, the media was incubated for 24 hours with a temperature of 370 C then the diameter of the inhibition zone was measured by the calipers. The results of the inhibitory diameter zone outside the well of the kencur rhizome extract were concentrations of 20%, 40%, 60%, and 80%, namely 3.92 mm, 4.07 mm, 4.87 mm and 5.9 mm respectively. The Kruskal Wallis statistical test results p = 0.002. 70% ethanol extract of kencur rhizome (Kaempferia galanga L.) has antibacterial activity against Staphylococcus epidermidis. There are effects at concentrations of 20%, 40%, 60% and 80%

Pengaruh Pemberian Ekstrak Etanol 70% Stroberi (Fragaria X Annanassa Duchesne) Terhadap Kerusakan Morfologi Hepar Mencit (Mus Musculus) Yang Diinduksi Parasetamol Dosis Toksik

Strawberries (Fragaria x annanassa Duchesne) contains a wide variety of antioxidants, namely: flavonoids, ellagic acid, anthocyanins and vitamin C. Antioxidants are thought to have the effect to protect the liver from damage caused by oxidative stress. For this study to determine the effect of 70% ethanol extract of strawberry (Fragaria x annnanassa) in reducing core histological damage due pe mice hepatocyte mberian paracetamol. This research is an experimental laboratory methods With Post Test Only Control Group Design. Test animals used were 30 male mice (Mus musculus) strain male Swiss Webster 2-3 months old weighing 20-30 grams were divided into 5 groups: control group was given distilled Positive, Negative Control group was given 5.07 mg paracetamol / 20 grBB, treatment Group I (0.5 mg / 20 grBB mice), treatment Group II (1.0 mg / 20 grBB), and Group III treatment (2.0 mg / 20 grBB). Damage to liver cells was measured by counting the number of damaged cells that focuses on necrosis. Data were analyzed with the Kruskal-Wallis and Mann Whitney Post Hoc test. 70% ethanol extract of strawberry (Fragaria x annanassa Duchesne) dose of 0.5 mg / grBB, 1.0 mg / grBB, and 2.0 mg / grBB proven already provide a protective effect on liver cells of mice morphological damage due to toxic doses of paracetamol

Hubungan Antara Penggunaan Kontrasepsi dan Usia Pernikahan terhadap Kejadian Kanker Serviks di RSUD dr. Moewardi Surakarta

Cervical cancer is caused by the Human Papilloma Virus. Risk factors for cervical cancer include the use of hormonal contraception and the age of early marriage. There are differences in the results of research on risk factors for the incidence of cervical cancer. This study aims to determine the relationship between contraceptive use and age of first marriage to the incidence of cervical cancer in DR Moewardi General Hospital Surakarta This study uses analytic observational research with Case Control research design. This research was conducted at the Dr. Moewardi General Hospital Surakarta in December 2018. The number of research samples is 68 medical records with Purposive Sampling techniques. Statistical analysis using Chi Square test. The results of univariate analysis found that the number of contraceptive use 3 years as many as 43 samples. The results of univariate analysis of age of first marriage < 20 years were 19 and 49 samples has age of first marriage 20 years. The results of bivariate analysis have a relationship between contraceptive use and cervical cancer incidence (p = 0.012) and there is no relationship between age of first marriage and cervical cancer (p = 1,000). Based on the research that has been done can be concluded that there is a relationship of the use of contraceptives with the incidence of cervical cancer but there is no relationship between the age of first marriage with the incidence of cervical cancer

Uji Efek Analgesik Ekstrak Methanol Kulit Pisang Kepok (Musa paradisiaca) pada Mencit (Mus musculus) Putih Jantan Galur Swiss

Background: Banana or Musa paradisiaca (commonly called pisang kepok in Indonesian) is one of the most cultivated fruit. Till date, the stem and the leaves of banana fruit have been proven to have analgesic effect. However, there is no study for analgesic effect of banana peel. Flavonoid which contained in banana peel is thought to be responsible for the analgesic effect of the fruit. Objective: To study the analgesic effect of methanolic extract of banana (Musa paradisiaca) peel. Method: The method used in this research was post test only with controlled group design. The laboratory animals used were 30 Swiss strain male albino mice (Mus musculus) which divided into 5 treatment groups; group I as negative control group given aquadest, group II as positive control group given Ibuprofen with dose 450 mg/kgBW, group III as the treatment group I given EMKP dose 500 mg/kgBW, group IV as treatment group II given EMKP dose 1000 mg/kgBW, group V as treatment group III given EMKP dose 1,500 mg/kgBW. Results: Based on the result of Kruskal-Wallis statistic test, p = 0,000, which means p < 0,05 significant. Mann-Whitney test results obtained between negative control group and treatment group 1, 2 and 3; p = 0,000; p = 0,000; p = 0.000 (p < 0.05) which mean the results are significantly different. Conclusion: Methanolic extract of banana (Musa paradisiaca) peel has an analgesic effect on Swiss strain male albino mice (Mus musculus)

Aktivitas Antibakteri Minyak Atsiri Daun Sirih Merah (Piper crocatum Ruiz & Pav) Terhadap Staphylococcus aureus Dan Escherichia coli Secara In Vitro

Red betel plant (Piper crocatum Ruiz & Pav) is a traditional plant which has antibacterial function. One of the compounds in red betel which has the ability as an antibacterial is the essential oil. The mechanism of red betel essential oil in inhibiting bacterial growth is by disrupting the integrity of the cell's membrane. The purpose of this experiment was to determine the antibacterial activity of essential oils of red betel (Piper crocatum Ruiz & Pav) against Staphylococcus aureus and Escherichia coli in vitro. Type of this research was experimental research with post test only with control group design method. The bacteria used were Staphylococcus aureus and Escherichia coli in agar nutrient media. Each bacteria received seven different treatments such as essential oil concentration 5%, 10%, 20%, 40%, 80%, positive control, and negative control. For Staphylococcus aureus, the positive control was amoxicillin. Meanwhile, for Escherichia coli the positive control was chloramphenicol. Antibacterial test using diffusion method with well technique

Uji Ekstrak Ethanol 70% Daun Kembang Bulan (Tithonia Diversifolia A. Gray) terhadap Efek Diuresis pada Tikus Putih Jantan Galur Wistar (Rattus Norvegicus)

Background : Hypertension is a condition when the blood pressure in the blood vessels chronically elevated. Data from the National Health and Nutrition Examination Survey (NHNES) since 1999-2000, the incidence of hypertension for adults is about 29-31%. the prevalence of hypertension in Indonesia was 26.5 percent. Now it is known as 5 groups of first-line drugs (first-line drug) that is commonly used for initial treatment of hypertension, one of diuretic which is diuretic drugs are made from chemicals that can cause many side effects, hence the need for an effort to minimize side effects through the use of herbs. Objective : To determine the diuresis effect of Kembang Bulan leaf (Tithonia diversifolia A.gray) extract on white male rats strain wistar (Rattus norvegicus). Kembang bulan leafe contain flavonoid group of flavonol that can causing diuresis effect by incresing natriuresis and klouresus mechanism. Method : The research is laboratory experimental using post test only control group design method. The research subjects are 30 white male rats (Rattus norvegicus) Strain wistar, the ages are around 2-3 mounths, weigh abaut 150-250 grams, devided to 5 groups. Group 1 was given 2ml/200grBW of aquades, group 2 was given 0,45 mg/200 grBW dosage in 2 ml solution of hidrochlortiazid, grup 3 was given kembang bulan leaf ekstract dosage I (0,6 gr/200 mgBw in 2 ml solution), grup 4 was given kembang bulan leaf ekstract dosage II (1,2 gr/200 mgBw in 2 ml solution), and grup 5 was given kembang bulan leaf ekstract dosage III (2,4 gr/200 mgBw in 2 ml solution), rat urine’s volume containment and measurement have to be done every 6 hours per day during observetion. Result : Stastitical calculating using Kruskal-Wallis shows significant differences of urine volume (p<0,05)n between treatment group. Conclusion : The summary of the research is showing Kembang Bulan leaves exstract dosage I and II have diuresis effect then dosage III has diuresis effect that par with hidrochlortiazid. Keyword : Extract, kembang bulan leaf (Tithonia diversifolia A.gray), diuresy

Uji Efek Analgesik Virgin Coconut Oil (VCO) Pada Mencit Putih (Mus musculus) Jantan Galur Swiss

Background: VCO (Virgin Coconut Oil) is one of the processed coconut (Cocos nucifera L). Virgin coconut oil is often called as tropical oils because this palm plants common in tropical regions. VCO (Virgin Coconut Oil) are believed to have an analgesic effect because there is a lauric acid content which can modulate the proliferation of immune cells that can suppress pain. Research Objective: To determine the analgesic effect in VCO (Virgin Coconut Oil). Research Method: The method used in the study Analgesic Effect Test VCO is by post test only with controlled group design. Test animals used were 25 male albino swiss mice (Mus musculus) and divided into five treatment groups: group I: as a negative control group, treated by distilled water, group II: as a control positive group, treated by Ibuprofen at a dose of 450mg / kg, group III: as the first treatment group, treated by VCO with dose of 0,15 ml , group IV: as the second treatment group, treated by VCO with dose of 0,3 ml, group V: as the third treatment group, treated by VCO with dose of 0,3 ml. Result of Research: Based on the Anova statistical test obtained by value p = 0.000 thus p < 0.05 means VCO (Virgin Coconut Oil) has an analgesic effect. Result of post hoc test showed negative between the groups (II) and the treatment group (III, IV, V) values; 0,000; 0.000; 0.000 (p < 0.05

Hubungan Antara Kualitas Hidup Ibu dengan Perkembangan Motorik Halus Balita di Posyandu Desa Bekonang Kecamatan Mojolaban Sukoharjo

Latar Belakang : Ibu adalah lingkungan terdekat dan pertama sekaligus pengasuh bagi perkembangan anak. Kualitas anak masa kini merupakan penentu Sumber Daya Manusia (SDM) dimasa yang akan datang. Pembangunan manusia masa depan dimulai dari pembangunan anak masa sekarang. Untuk mempersiapkan SDM yang berkualitas dimasa yang akan datang maka perlu dipersiapkan agar anak bisa tumbuh dan berkembang sesuai dengan kemampuannya. Tujuan Penelitian : Untuk mengetahui hubungan kualitas hidup ibu dan perkembangan motorik halus balita Metode Penelitian : Merupakan penelitian survei analitik dengan pendekatan cross sectional. Diambil sampel 43 orang ibu dan 43 balita, dengan teknik purposive sampling. Menggunakan uji statistik Chi-Square. Hasil :Pada 22 (51,3%) ibu berkualitas hidup baik mempunyai 2 balita (4,8%) dengan perkembangan motorik halus kurang, 11 balita (25,6%) normal, dan 9 balita (20,9%) lebih. Pada 21 ibu (48,7%) berkualitas hidup buruk terdapat 9 balita (20,9%) mempunyai perkembangan motorik halus kurang, 7 balita (16,2%) normal, dan 5 balita (11,6%) lebih. Dari hasil uji Chi-Square didapatkan X² = 6,467 dan probabilitas signifikansi (ρ) = 0,039. Kesimpulan : Terdapat hubungan antara kualitas hidup ibu dengan perkembangan motorik halus balita di posyandu wilayah kecamatan Bekonang Mojolaban Sukoharjo