STUDI FARMAKOKINETIKA BUPIVAKAIN 0,5% ISOBARIK PADA PASIEN PREEKLAMPSIA YANG MENJALANI SECTIO CAESAREA DENGAN TEKNIK ANESTESI EPIDURAL LUMBAL STUDI KASUS DI RSUP Dr. SARDJITO YOGYAKARTA

This research aims at knowing the pharmacokinetics profiles of isobaric bupivacaine 0.5% with the nonkompartemen model in preeclampsia patients SC with lumbar epidural in RSUP Dr. Sardjito and knowing correlation between protein levels and pharmacokinetics profiles of isobaric bupivacaine 0,5% in preeclampsia patients. The scope of the research is preeclampsia patients SC using bupivacaine 0,5% in lumbar epidural in Integrated Central Surgical Building (GBST) RSUP Dr. Sardjito Yogyakarta. The subjects are pregnancy fullterm, single fetus pregnancies/ twin, weight of body � 85kg, physical status ASA II-III, no fetal distress, no obvious signs of bleeding, no impairment of consciousness when live lumbar epidural anesthesia, willing to participants of this study and signed informed consent. Patients were checked in the laboratory for check albumin and then given isobaric bupivacaine 0.5% in 15ml (75mg) in lumbar epidural and blood taken at minute

KAJIAN DRUG-RELATED PROBLEMS DAN GAMBARAN KUALITAS HIDUP PASIEN HEMODIALISIS RUTIN LANJUT USIA DI RSUP DR. SARDJITO YOGYAKARTA

The growth of elderly population increase fastest among the other age group. The elderly population been related to decrease renal function and other comorbidity as consequence of aging. The elderly patient with chronic kidney failure on high risk of drug-related problem (DRP) so can attribute to patient�s quality of life (QoL). The aim of this study is to know how about corelation of DRP event and QoL of elderly patient on routine hemodialysis in RSUP Dr. Sardjito Yogyakarta. This is a cross sectional study about elderly patient on routine hemodialysis in RSUP Dr. Sardjito Yogyakarta on period October 22th 2012 � January 22th 2013. The study of DRP based on medication list then been analyzed theoritically and interview to patient. The measuring of QoL use SF-36 questionaire. Assessment of adherence and drug side effect use Modified Morisky Scale and Naranjo Scale. There were 38 subjects analized, age < 70 years old (24 patients) and � 70 years old (14 patients

PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 μg dan 100 μg TERHADAP LAMA PERSALINAN DI RSU PKU MUHAMMADIYAH YOGYAKARTA

Background: Stimulation is effort to add strength, frequency and duration of uterus contraction that is considered very weak or not effective to induce labor progress. Labor induction/stimulation occurs between 10% to 20% of all labors with various indications for mother and fetus. In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripening at pregnancy. However, until now misoprostol dosage and administration route for induction are various. There is no fix guide on administration and dosage of misoprostol. Objective: This research was intended to identify profile of misoprostol usage and effectiveness of misoprostol administration at dosage of 50 µg and 100 µg on labor process progress of patient hospitalized in YogyakartaPKUMuhammadiyahHospital based on induction success and induction period. Method: This was non experimental research with historical cohort design. Limitation of this method is not all desired data exist in medical record and capability of physician was not same. Subject was pregnant mothers giving birth with misoprostol induction process in delivery room in YogyakartaPKUMuhammadiyahHospital from 1 January 2009 to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptively analytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administration at 50 µg and 100 µg dosage on labor process progress. Results and conclusion: Research subject meeting inclusion criteria in this research was 109 mothers, where 69 women (63,30%) got 50 µg misoprostol and 40 women (36,70%) got 100 µg misoprostol. The results indicate that there was significant difference of induction success between 50 µg and 100 µg groups. Success of 50 µg misoprostol induction was lower than 100 µg misoprostol induction (81,16% vs 97.50

EVALUASI KUALITAS HIDUP PADA PENDERITA SIROSIS HATI DI INSTALASI RAWAT JALAN RSUP Dr. SARDJITO YOGYAKARTA

Patients with liver cirrhosis has various disease symptom disturbances which bring negative effects to their quality of life. There are a lot of efforts done in order the patients with chronic liver cirrhosis can feel better and recover their quality of life. The improvement of quality of life is important as one of the purposes on chronic diseases therapy, at Dr. Sardjito Hospital Yogyakarta. This research is generally designed to evaluate factors influencing the quality of life on patients with liver cirrhosis. This research is observational research with cross sectional plan. The data recording was done concurrentl

ANALISIS TREND PENGELOLAAN OBAT DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH SLEMAN PERIODE 2009 � 2011

Drug management in hospital should be managed efficiently and effectively. Drug availability and usage in hospital is important aspect influencing health service. Pharmacy unit of Sleman regional Hospital should do trend analysis as long term monitoring of drug management. Obtained trend may provide information on description, evaluation and activities related to policy of drug management in Sleman Regional Hospital. Objective of the research is to identify description and trend of drug management in Pharmacy Unit of Sleman regional Hospital in 2009-2011. It was descriptive research by taking data in retrospective and prospective technique. Data was taken according to population and stratified random sampling (frequency of drug item procurement). Data of drug management was analyzed using indicator of DepKes RI, WHO dan Pudjaningsih. Result of the research in period of 2009-2011 was (1) selection, drug suitability with DOEN (41.23%, 41.23% and 39.26

PERBANDINGAN DOSIS WARFARIN 3 dan 5 mg PADA PASIEN ATRIAL FIBRILASI DI RSAL Dr. RAMELAN SURABAYA

One goal of atrial fibrillation treatment is to prevent complication of thromboemboli using warfarin anticoagulant. Warfarin can reduce stroke risk, but it increases bleeding risk than control therapy. To obtain desirable therapeutic effects and minimize bleeding risk, strict control of patients INR needs to do. The goal of research was to give illustration of therapeutic length to reach INR target and side effects of drug in initial dosage use of 3 and 5 mg warfarin on AF patient. Experimental research using data collection technique was conducted prospectively in 20 patients to compare therapeutic length to reach INR target and side effects of drug in AF patients after giving 3 and 5 mg warfarin, from July 2011 to November 2011. Results of laboratory examination, therapeutic length (day) to reach INR target of 5 mg warfarin dosage groups were 3rd day (1 patient), 4th day (5 patients), 5th day (4 patients), respectively and 3 mg warfarin dosage groups were 4th day (1 patient), 5th day (4 patients), 6th Therapeutic length to reach INR target of 5 mg warfarin dosage groups was 4,30 ± 0,21 day, than 3 mg warfarin 5,40 ± 0,22 day (p < 0.05). Side effects of bleeding such as blackish feces occurred in 1 (of 10 patients) of 5 mg warfarin dosage group

Evaluasi Dampak Kebijakan Harga Obat Generik Tahun 2010 terhadap Harga Jual, Ketersediaan, dan Keterjangkauan Obat di Apotek Swasta Kabupaten Jember

One of government�s efforts to guarantee people access of essential medicine is by applying a policy concerning with medicine prices. The purpose of the research is to find out the variation and the ratio of generic and branded medicine selling prices in comparison with Harga Jual Apotek (HJA) � Pharmacy Selling Price � base on the regulation of Health Department and International Reference Prices (IRPs) 2010 in some private pharmacies in Jember, and their availability and affordability. The research is a descriptive non experimental one. The data used is prescription document during April-August 2010. The data collecting is done retrospectively toward generic and branded medicines mostly given, including their prices and affordability. The ratio of generic medicine selling price toward HJA of Health Department 2010 is 0.14-9.09 times and for branded medicine, it is 0.26-114.06. On the other hand, the ratio of generic medicine selling price toward IRPs 2010 is 0.03-16.67 times, and 0.09-501.88 times for branded medicine. Out of 50 kinds of mostly given medicines, 35 of them are generic medicines with the percentage of availability range as much as 6.8%-100%, while 15 of them are branded medicines with the range of 11.4%-93.2%. In the matter of affordability, it needs 1 working day to do a therapy using generic medicines for diabetes mellitus, hypertension, hypercholesterolemia, rheumatoid arthritis, and infection cases. In contrast, it requires 1-35 working days to do those therapies using branded medicines with Regional Minimum Salary of Rp.33.200,00 for each working day. Base on the research, it shows that there is no conformity of generic and branded medicines selling prices between the rate which has been decided by the government and on real practice

PENGARUH GAYA KEPEMIMPINAN DAN BUDAYA ORGANISASI TERHADAP KOMITMEN DAN PRODUKTIVITAS KARYAWAN (STUDI DI DIVISI PRODUKSI PT. AIR MANCUR SOLO)

Human resource is the most important asset for any organization or company. Human resource has a main role in creating and maintaining good performance and competitive advantage and also will serve as valuable power for company to survive in regional or global competition. Good leadership is an aspect of human resource that creates good system and organizational culture in which contributes in producing high performance and productivity of company�s employee. Leadership and organizational culture have been known as factors that could induce employee commitment in giving their best for organization and company. Various researches concluded that leadership, organizational culture, commitment, and productivity have positive correlation one another. This study aims to explore the relationship among four variables, which are leadership, organizational culture, organizational commitment, and productivity, in context of pharmaceutical industry, partially and simultaniously. This study was a nonexperimental study with associative analytic. Nonprobability purposive sampling was utilized to determine samples. The total number of sample was 50 respondents. The data was collected using questionnaire describing leadership style, organizational culture, organizational commitment, and productivity. Data were analyzed using linear regression, and Pearson correlation to determine relationship between each variables. Path analysis was used to determine mediation effect of variable. The results of analysis showed that there was positive and significant effect among each variables (p < 0,05). The result also showed simultanious effect of leadership and organizational culture to organizational commitment and productivity (p < 0,05). Mediation effect of organizational culture was proven between leadership to organizational commitment and productivity

AKIBAT PENGGUNAAN OBAT ANTIHIPERTENSI PORTAL TERHADAP EPISODE KEJADIAN HEMATEMESIS-MELENA PADA PASIEN DENGAN SIROSIS HATI DI RSUP Dr SARDJITO YOGYAKARTA

Background : Hematemesis and/or melena are complaints frequently occurring in patients with heart sirosis with varicose veins of gastroesophagous. Hematemesis and/or melena occur because there is varicose vein bleeding. Each bleeding episode brings mortality rate ranged from 25% to 30%. Prevention of varicose vein bleeding using appropriate portal anti-hypertensive medicine may minimize mortality risk. Purpose : This research aimed to understand profile of use of portal antihypertension and evaluate use of portal anti-hypertensive medicine consisting of: exact dosage and therapy outcome. Method : This research is observational-descriptive study and it was conducted retrospectively. Subjects of research were patients of RSPU Dr. Sardjito Yogyakarta receiving portal anti-hypertensive medicine from January of 2008 to December of 2010. Collectable data were reviewed and discussed by references of most recent guidelines. Result : 41 inclusive cases indicated that 92.7% of patients used propranolol and 7.3% of patients used isosorbid mononitrate. Given outcome of use of portal antihypertensive medicine based on hematemesis and/or melena incidences in patients using propranolol as primary prophylaxis, one patient (11.1%) experienced hematemesis, while, in patients using isosorbid mononitrate, it could prevent incidence of hematesis and/or melena. In patients using propranolol as secondary prophylaxis, 11 patients (37.9%) experienced hemetemesis and/or melena, while in patients using isosorbid mononitrate, it could not prevent incidence of hematesis and/or melena. Conclusion : In propranolol secondary prophylaxis, there were 9 patients using propranolol and one patient using isosorbid mononitrate. Based on achievable responses, there was one patient experiencing hematemesis. It was caused by non optimum propranolol dosage. While one patient using isosorbid mononitrate could prevent hematemesis and/or melena in patients with liver Cirrhosis. In secondary prophylaxis, there were 29 patients using propranolol and two patients using isosorbid mononitrate. Based on achievable responses, there were 11 patients using propranolol experiencing hematemesis and/or melena. It was caused by non optimum propranolol dosage and there was one patient using propranolol experiencing hematemesis and/or melena