THE DIFFERENCE OF TRANSAMINASE LEVEL IN GALLSTONES LOCATION OF GALLSTONE PATIENTS IN RSUP DR SARDJITO

ABSTRACT Background: Gallstone can occur anywhere within the biliary tree, including the gallbladder and the common bile duct. To identify a biliary etiology, several biochemical investigations have been proposed including bilirubin, ALT, AST, GGT, and alkaline phosphatase. Objectives: To know the difference between the location of gallstones and the level of transaminase. Method: The data of cholelithiasis patient is collected by analysing the medical records obtained from RSUP Dr. Sardjito in 2010 to 2013. The medical record chosen is cholelithiasis patients who were diagnosed by the internist and undergo surgery to remove the stones and classified into cholelithiasis, choledocholithiasis and both cholelithiasis and choledocholithiasis. The data is analysed by using computer. Result: Shapiro-Wilk Test is used for normality test. The difference of transaminase level based on gallstones location was analysed using Kruskal-Wallis H Test. In SGOT, there is statistically significant difference between the gallstone location, (H=18.84,p=0.000), with a mean rank of 52.69 for cholelithiasis, 88.88 for choledocholithiasis, 87.21 for cholelithiasis and choledocholithiasis. In SGPT, there is a statistically significant difference between the three groups of gallstone location, (H=13.52,p=0.001), with a mean rank of 55.61 for cholelithiasis, 81.17 for choledocholithiasis, 86.29 for cholelithiasis and choledocholithiasis. Conclusion: Based on the study, there is difference in the value of SGOT and SGPT according to the gallstones location