1 research outputs found
HUBUNGAN ANTARA HEPATOTOKSISITAS DENGAN USIA, STATUS GIZI, DAN LAMA PEMBERIAN ASAM VALPROAT PADA ANAK EPILEPSI
Epilepsy is still a disease that affects many people all around the world with
an estimated 50 million people suffer from epilepsy. The annual incidence rate ranges
from 20-70 cases per 100,000 population and the prevalence rate from 0.4 to
0.8 percent. The high prevalence of epilepsy will directly impact on the high use
of valproic acid in children and this may increase the risk of hepatotoxicity. The aim
of this study is to investigate the relationship between the age, nutritional status,
duration of therapy and hepatotoxicity in epileptic children who
received valproic acid.
This is a cross-sectional study. The data taken in September-November 2011
in the department of pediatric neurology of DR. Sardjito Hospital Yogyakarta. The
inclusion criteria were children with epilepsy aged < 18 years who received valproic
acid therapy for at least 3 months as outpatient who willing to follow the study.
Exclusion criteria were children with no previous liver disease. Data processed
using Pearson and Spearman correlation. This study showed no association between
age of patient and hepatotoxicity in children with epilepsy using valproic acid (r = -
0.009, p = 0.946). Other factors that were tested showed no
association between duration of therapy, nutritional status and hepatotoxicity (r =
0.009, p = 0.947 and r = -0.198, p = 0.136 irrespectively).
The age of patient, nutritional status, duration of therapy are not
associated with hepatotoxicity in children with epilepsy who received valproic acid