UJI TOKSISITAS ENDOSULFAN TERHADAP IKAN NILA (Oreochromis niloticus)

The research was to determine endosulfan toxic dose and to know pathological changes was caused by endosulfan pesticide in nila fish (Oreochromis niloticus). Research was done in Pathology laboratory Faculty of Veterinary Medicine of Gadjah Mada University. Preliminary research was to find out LC50 of insecticide to Nila fish. Seven aquariums, size of 40x20x25 contained 5 Nila fish with size 0f 8-10 cm for each repeated twice. Each group given insecticide with highest concentrate caused all the fish died and the lowest concentrate where all of the fish were still survive. This first treatment tested on three aquariums and one aquarium as a control (don�t use endosulfan) which containts five litter water and five nila fish. Each treatment done two replicates. The fishs which die are nekroption to histopatological examination. Toxicity dose for the first test were 1/8, 2/8 and 3/8 from LC50. The result LC50 determined with the Reed-Muench method was 0,062 ppb. Dose which was used in first test were 0,008 pp