PENGGUNAAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana) SEBAGAI LARVISIDA TERHADAP LARVA NYAMUK Culex quinquefasciatus

Background. Lymphatic Filariasis is disease caused by parasite whereas 120 million people who live in tropic and subtropic area already infected. Its transmission is via mosquito bite so controlling mosquito using synthetic insecticide becoming usual. However, using synthetic insecticide extensively causes enviranmental pollution and resistency. Therefore, it is important to find alternative larvicide which is safe and natural. In daily routine, mangosteen pericarp is rarely use while it contain alpha mangostin which can be used as larvicide. Objectives. To explore effect of Garcinia mangostana pericarp with ethanol extract as larvicide against larvae of Culex quinquefasciatus. Methode. This research uses simple experimental research design. Instar III-IV larvae divided into 7 treatment group and 1 control group with each group consist of 10 larvae with three times replication, in 10 ml solution. Larvae mortality counted after 24 hours and the data analyzed using probit analysis and ONE WAY ANOVA. Results. The LC50 dan LC90 values were 3.147,99 ppm and 9.983,82ppm dosage of the extract. Conclusion. Ethanol extraction of mangosteen (Garcinia mangostana) pericarp has larvicide effect against instar III-IV Culex quinquefasciatus mosquito and increasing its concentration result in increased larvae mortality but ineffective