Volumetric texture segmentation by discriminant feature selection and multiresolution classification

In this paper, a multiresolution volumetric texture segmentation (M-VTS) algorithm is presented. The method extracts textural measurements from the Fourier domain of the data via subband filtering using an orientation pyramid (Wilson and Spann, 1988). A novel Bhattacharyya space, based on the Bhattacharyya distance, is proposed for selecting the most discriminant measurements and producing a compact feature space. An oct tree is built of the multivariate features space and a chosen level at a lower spatial resolution is first classified. The classified voxel labels are then projected to lower levels of the tree where a boundary refinement procedure is performed with a three-dimensional (3-D) equivalent of butterfly filters. The algorithm was tested with 3-D artificial data and three magnetic resonance imaging sets of human knees with encouraging results. The regions segmented from the knees correspond to anatomical structures that can be used as a starting point for other measurements such as cartilage extraction

Quantitative MRI Brain Studies in Mild Cognitive Impairment and Alzheimer's disease: A Methodological Review

Classifying and predicting Alzheimer's disease (AD) in individuals with memory disorders through clinical and psychometric assessment is challenging especially in Mild Cognitive Impairment (MCI) subjects. Quantitative structural Magnetic Resonance Imaging (MRI) acquisition methods in combination with Computer-Aided Diagnosis (CAD) are currently being used for the assessment AD. These acquisitions methods include: i) Voxel-based Morphometry (VBM), ii) volumetric measurements in specific Regions of Interest (ROIs), iii) cortical thickness measurements, iv) shape analysis and v) texture analysis. This review evaluates the aforementioned methods in the classification of cases into one of the following 3 groups: Normal Controls (NC), MCI and AD subjects. Furthermore, the performance of the methods is assessed on the prediction of conversion from MCI to AD. In parallel, it is also assessed which ROIs are preferred in both classification and prognosis through the different states of the disease. Structural changes in the early stages of the disease are more pronounced in the Medial Temporal Lobe (MTL) especially in the entorhinal cortex, whereas with disease progression both entorhinal cortex and hippocampus offer similar discriminative power. However, for the conversion from MCI subjects to AD, entorhinal cortex provides better predictive accuracies rather than other structures, such as the hippocampus

2D and 3D segmentation of medical images.

"Cardiovascular disease is one of the leading causes of the morbidity and mortality in the western world today. Many different imaging modalities are in place today to diagnose and investigate cardiovascular diseases. Each of these, however, has strengths and weaknesses. There are different forms of noise and artifacts in each image modality that combine to make the field of medical image analysis both important and challenging. The aim of this thesis is develop a reliable method for segmentation of vessel structures in medical imaging, combining the expert knowledge of the user in such a way as to maintain efficiency whilst overcoming the inherent noise and artifacts present in the images. We present results from 2D segmentation techniques using different methodologies, before developing 3D techniques for segmenting vessel shape from a series of images. The main drive of the work involves the investigation of medical images obtained using catheter based techniques, namely Intra Vascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT). We will present a robust segmentation paradigm, combining both edge and region information to segment the media-adventitia, and lumenal borders in those modalities respectively. By using a semi-interactive method that utilizes "soft" constraints, allowing imprecise user input which provides a balance between using the user's expert knowledge and efficiency. In the later part of the work, we develop automatic methods for segmenting the walls of lymph vessels. These methods are employed on sequential images in order to obtain data to reconstruct the vessel walls in the region of the lymph valves. We investigated methods to segment the vessel walls both individually and simultaneously, and compared the results both quantitatively and qualitatively in order obtain the most appropriate for the 3D reconstruction of the vessel wall. Lastly, we adapt the semi-interactive method used on vessels earlier into 3D to help segment out the lymph valve. This involved the user interactive method to provide guidance to help segment the boundary of the lymph vessel, then we apply a minimal surface segmentation methodology to provide segmentation of the valve.

Quantitative texture analysis in MR imaging in the assessment of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease which is clinically characterized by cognitive impairment and memory loss. Anatomically, AD initially affects specific structures within the Medial Temporal Lobe (MTL), which are essential for declarative memory. A definitive diagnosis of AD relies on post-mortem biopsy therefore, clinical assessment and cognitive tests are currently used. However, these tests are not sensitive to detect AD in an early stage. The aim of this research was to investigate the usefulness of quantitative Magnetic Resonance Imaging (MRI) and specifically of texture features in the assessment of Mild Cognitive Impairment (MCI) which is the pre-dementia stage and AD. Firstly, two types of magnetic fields where investigated in order to examine whether, a stronger MR magnetic field would benefit quantitative imaging analysis derived from texture features. Secondly, texture features were extracted from the entorhinal cortex and evaluated in the diagnosis and prediction of MCI and AD. To the best of our knowledge this is the first research that investigated how the MR field strength affects texture features and used entorhinal cortex texture features on the assessment of AD. The main results of this PhD showed that (1) texture features could provide more sensitive measures when they are extracted from stronger MRI magnetic field, such as 3T, compared to 1.5T. From a disease classification and prediction perspective, (2) entorhinal cortex texture features provide better classification between Normal Controls (NC), MCI and AD subjects, and (3) better prediction of the conversion from MCI to AD. In conclusion, this research has shown for the first time in the literature that entorhinal cortex texture features from MRI could contribute towards the early classification of AD