21,090 research outputs found

    Cost-effectiveness analysis in R using a multi-state modelling survival analysis framework: a tutorial

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    This tutorial provides a step-by-step guide to performing cost-effectiveness analysis using a multi-state modelling approach. Alongside the tutorial we provide easy-to-use functions in the statistics package R. We argue this multi-state modelling approach using a package such as R has advantages over approaches where models are built in a spreadsheet package. In particular, using a syntax-based approach means there is a written record of what was done and the calculations are transparent. Reproducing the analysis is straightforward as the syntax just needs to be run again. The approach can be thought of as an alternative way to build a Markov decision analytic model, which also has the option to use a state-arrival extended approach if the Markov property does not hold. In the state-arrival extended multi-state model a covariate that represents patients’ history is included allowing the Markov property to be tested. We illustrate the building of multi-state survival models, making predictions from the models and assessing fits. We then proceed to perform a cost-effectiveness analysis including deterministic and probabilistic sensitivity analyses. Finally, we show how to create two common methods of visualising the results, namely cost-effectiveness planes and cost-effectiveness acceptability curves. The analysis is implemented entirely within R. It is based on adaptions to functions in the existing R package mstate, to accommodate parametric multi-state modelling which facilitates extrapolation of survival curves

    The SSDC contribution to the improvement of knowledge by means of 3D data projections of minor bodies

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    The latest developments of planetary exploration missions devoted to minor bodies required new solutions to correctly visualize and analyse data acquired over irregularly shaped bodies. ASI Space Science Data Center (SSDC-ASI, formerly ASDC-ASI Science Data Center) worked on this task since early 2013, when started developing the web tool MATISSE (Multi-purpose Advanced Tool for the Instruments of the Solar System Exploration) mainly focused on the Rosetta/ESA space mission data. In order to visualize very high-resolution shape models, MATISSE uses a Python module (vtpMaker), which can also be launched as a stand-alone command-line software. MATISSE and vtpMaker are part of the SSDC contribution to the new challenges imposed by the "orbital exploration" of minor bodies: 1) MATISSE allows to search for specific observations inside datasets and then analyse them in parallel, providing high-level outputs; 2) the 3D capabilities of both tools are critical in inferring information otherwise difficult to retrieve for non-spherical targets and, as in the case for the GIADA instrument onboard Rosetta, to visualize data related to the coma. New tasks and features adding valuable capabilities to the minor bodies SSDC tools are planned for the near future thanks to new collaborations

    Mapping crime: Understanding Hotspots

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    Geographically Referenced Data for Social Science

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    An estimated 80% of all information has a spatial reference. Information about households as well as environmental data can be linked to precise locations in the real world. This offers benefits for combining different datasets via the spatial location and, furthermore, spatial indicators such as distance and accessibility can be included in analyses and models. HSpatial patterns of real-world social phenomena can be identified and described and possible interrelationships between datasets can be studied. Michael F. GOODCHILD, a Professor of Geography at the University of California, Santa Barbara and principal investigator at the Center for Spatially Integrated Social Science (CSISS), summarizes the growing significance of space, spatiality, location, and place in social science research as follows: "(...) for many social scientists, location is just another attribute in a table and not a very important one at that. After all, the processes that lead to social deprivation, crime, or family dysfunction are more or less the same everywhere, and, in the minds of social scientists, many other variables, such as education, unemployment, or age, are far more interesting as explanatory factors of social phenomena than geographic location. Geographers have been almost alone among social scientists in their concern for space; to economists, sociologists, political scientists, demographers, and anthropologists, space has been a minor issue and one that these disciplines have often been happy to leave to geographers. But that situation is changing, and many social scientists have begun to talk about a "spatial turn," a new interest in location, and a new "spatial social science" that crosses the traditional boundaries between disciplines. Interest is rising in GIS (Geographic Information Systems) and in what GIS makes possible: mapping, spatial analysis, and spatial modelling. At the same time, new tools are becoming available that give GIS users access to some of the big ideas of social science."

    Detecting and Tracking the Spread of Astroturf Memes in Microblog Streams

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    Online social media are complementing and in some cases replacing person-to-person social interaction and redefining the diffusion of information. In particular, microblogs have become crucial grounds on which public relations, marketing, and political battles are fought. We introduce an extensible framework that will enable the real-time analysis of meme diffusion in social media by mining, visualizing, mapping, classifying, and modeling massive streams of public microblogging events. We describe a Web service that leverages this framework to track political memes in Twitter and help detect astroturfing, smear campaigns, and other misinformation in the context of U.S. political elections. We present some cases of abusive behaviors uncovered by our service. Finally, we discuss promising preliminary results on the detection of suspicious memes via supervised learning based on features extracted from the topology of the diffusion networks, sentiment analysis, and crowdsourced annotations
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