3,217 research outputs found
Computational study of resting state network dynamics
Lo scopo di questa tesi è quello di mostrare, attraverso una simulazione con il software The Virtual Brain, le più importanti proprietà della dinamica cerebrale durante il resting state, ovvero quando non si è coinvolti in nessun compito preciso e non si è sottoposti a nessuno stimolo particolare. Si comincia con lo spiegare cos’è il resting state attraverso una breve revisione storica della sua scoperta, quindi si passano in rassegna alcuni metodi sperimentali utilizzati nell’analisi dell’attività cerebrale, per poi evidenziare la differenza tra connettività strutturale e funzionale. In seguito, si riassumono brevemente i concetti dei sistemi dinamici, teoria indispensabile per capire un sistema complesso come il cervello. Nel capitolo successivo, attraverso un approccio ‘bottom-up’, si illustrano sotto il profilo biologico le principali strutture del sistema nervoso, dal neurone alla corteccia cerebrale. Tutto ciò viene spiegato anche dal punto di vista dei sistemi dinamici, illustrando il pionieristico modello di Hodgkin-Huxley e poi il concetto di dinamica di popolazione. Dopo questa prima parte preliminare si entra nel dettaglio della simulazione. Prima di tutto si danno maggiori informazioni sul software The Virtual Brain, si definisce il modello di network del resting state utilizzato nella simulazione e si descrive il ‘connettoma’ adoperato. Successivamente vengono mostrati i risultati dell’analisi svolta sui dati ricavati, dai quali si mostra come la criticità e il rumore svolgano un ruolo chiave nell'emergenza di questa attività di fondo del cervello. Questi risultati vengono poi confrontati con le più importanti e recenti ricerche in questo ambito, le quali confermano i risultati del nostro lavoro. Infine, si riportano brevemente le conseguenze che porterebbe in campo medico e clinico una piena comprensione del fenomeno del resting state e la possibilità di virtualizzare l’attività cerebrale
Can biological quantum networks solve NP-hard problems?
There is a widespread view that the human brain is so complex that it cannot
be efficiently simulated by universal Turing machines. During the last decades
the question has therefore been raised whether we need to consider quantum
effects to explain the imagined cognitive power of a conscious mind.
This paper presents a personal view of several fields of philosophy and
computational neurobiology in an attempt to suggest a realistic picture of how
the brain might work as a basis for perception, consciousness and cognition.
The purpose is to be able to identify and evaluate instances where quantum
effects might play a significant role in cognitive processes.
Not surprisingly, the conclusion is that quantum-enhanced cognition and
intelligence are very unlikely to be found in biological brains. Quantum
effects may certainly influence the functionality of various components and
signalling pathways at the molecular level in the brain network, like ion
ports, synapses, sensors, and enzymes. This might evidently influence the
functionality of some nodes and perhaps even the overall intelligence of the
brain network, but hardly give it any dramatically enhanced functionality. So,
the conclusion is that biological quantum networks can only approximately solve
small instances of NP-hard problems.
On the other hand, artificial intelligence and machine learning implemented
in complex dynamical systems based on genuine quantum networks can certainly be
expected to show enhanced performance and quantum advantage compared with
classical networks. Nevertheless, even quantum networks can only be expected to
efficiently solve NP-hard problems approximately. In the end it is a question
of precision - Nature is approximate.Comment: 38 page
Fractals in the Nervous System: conceptual Implications for Theoretical Neuroscience
This essay is presented with two principal objectives in mind: first, to
document the prevalence of fractals at all levels of the nervous system, giving
credence to the notion of their functional relevance; and second, to draw
attention to the as yet still unresolved issues of the detailed relationships
among power law scaling, self-similarity, and self-organized criticality. As
regards criticality, I will document that it has become a pivotal reference
point in Neurodynamics. Furthermore, I will emphasize the not yet fully
appreciated significance of allometric control processes. For dynamic fractals,
I will assemble reasons for attributing to them the capacity to adapt task
execution to contextual changes across a range of scales. The final Section
consists of general reflections on the implications of the reviewed data, and
identifies what appear to be issues of fundamental importance for future
research in the rapidly evolving topic of this review
Disentangling causal webs in the brain using functional Magnetic Resonance Imaging: A review of current approaches
In the past two decades, functional Magnetic Resonance Imaging has been used
to relate neuronal network activity to cognitive processing and behaviour.
Recently this approach has been augmented by algorithms that allow us to infer
causal links between component populations of neuronal networks. Multiple
inference procedures have been proposed to approach this research question but
so far, each method has limitations when it comes to establishing whole-brain
connectivity patterns. In this work, we discuss eight ways to infer causality
in fMRI research: Bayesian Nets, Dynamical Causal Modelling, Granger Causality,
Likelihood Ratios, LiNGAM, Patel's Tau, Structural Equation Modelling, and
Transfer Entropy. We finish with formulating some recommendations for the
future directions in this area
Neural Connectivity with Hidden Gaussian Graphical State-Model
The noninvasive procedures for neural connectivity are under questioning.
Theoretical models sustain that the electromagnetic field registered at
external sensors is elicited by currents at neural space. Nevertheless, what we
observe at the sensor space is a superposition of projected fields, from the
whole gray-matter. This is the reason for a major pitfall of noninvasive
Electrophysiology methods: distorted reconstruction of neural activity and its
connectivity or leakage. It has been proven that current methods produce
incorrect connectomes. Somewhat related to the incorrect connectivity
modelling, they disregard either Systems Theory and Bayesian Information
Theory. We introduce a new formalism that attains for it, Hidden Gaussian
Graphical State-Model (HIGGS). A neural Gaussian Graphical Model (GGM) hidden
by the observation equation of Magneto-encephalographic (MEEG) signals. HIGGS
is equivalent to a frequency domain Linear State Space Model (LSSM) but with
sparse connectivity prior. The mathematical contribution here is the theory for
high-dimensional and frequency-domain HIGGS solvers. We demonstrate that HIGGS
can attenuate the leakage effect in the most critical case: the distortion EEG
signal due to head volume conduction heterogeneities. Its application in EEG is
illustrated with retrieved connectivity patterns from human Steady State Visual
Evoked Potentials (SSVEP). We provide for the first time confirmatory evidence
for noninvasive procedures of neural connectivity: concurrent EEG and
Electrocorticography (ECoG) recordings on monkey. Open source packages are
freely available online, to reproduce the results presented in this paper and
to analyze external MEEG databases
Neurofeedback: principles, appraisal and outstanding issues
Neurofeedback is a form of brain training in which subjects are fed back
information about some measure of their brain activity which they are
instructed to modify in a way thought to be functionally advantageous. Over the
last twenty years, NF has been used to treat various neurological and
psychiatric conditions, and to improve cognitive function in various contexts.
However, despite its growing popularity, each of the main steps in NF comes
with its own set of often covert assumptions. Here we critically examine some
conceptual and methodological issues associated with the way general objectives
and neural targets of NF are defined, and review the neural mechanisms through
which NF may act, and the way its efficacy is gauged. The NF process is
characterised in terms of functional dynamics, and possible ways in which it
may be controlled are discussed. Finally, it is proposed that improving NF will
require better understanding of various fundamental aspects of brain dynamics
and a more precise definition of functional brain activity and brain-behaviour
relationships.Comment: 12 page
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