From normal brain and behavior to schzophrenia

Air Force Office of Scientific Research (F49620-01-1-0397); Office of Naval Research (N00014-01-1-0624

The Complementary Brain: From Brain Dynamics To Conscious Experiences

How do our brains so effectively achieve adaptive behavior in a changing world? Evidence is reviewed that brains are organized into parallel processing streams with complementary properties. Hierarchical interactions within each stream and parallel interactions between streams create coherent behavioral representations that overcome the complementary deficiencies of each stream and support unitary conscious experiences. This perspective suggests how brain design reflects the organization of the physical world with which brains interact, and suggests an alternative to the computer metaphor suggesting that brains are organized into independent modules. Examples from perception, learning, cognition, and action are described, and theoretical concepts and mechanisms by which complementarity is accomplished are summarized.Defense Advanced Research Projects and the Office of Naval Research (N00014-95-1-0409); National Science Foundation (ITI-97-20333); Office of Naval Research (N00014-95-1-0657

Neural Dynamics of Autistic Behaviors: Cognitive, Emotional, and Timing Substrates

What brain mechanisms underlie autism and how do they give rise to autistic behavioral symptoms? This article describes a neural model, called the iSTART model, which proposes how cognitive, emotional, timing, and motor processes may interact together to create and perpetuate autistic symptoms. These model processes were originally developed to explain data concerning how the brain controls normal behaviors. The iSTART model shows how autistic behavioral symptoms may arise from prescribed breakdowns in these brain processes.Air Force Office of Scientific Research (F49620-01-1-0397); Office of Naval Research (N00014-01-1-0624

The Complementary Brain: A Unifying View of Brain Specialization and Modularity

Defense Advanced Research Projects Agency and Office of Naval Research (N00014-95-I-0409); National Science Foundation (ITI-97-20333); Office of Naval Research (N00014-95-I-0657

A neural network model of adaptively timed reinforcement learning and hippocampal dynamics

A neural model is described of how adaptively timed reinforcement learning occurs. The adaptive timing circuit is suggested to exist in the hippocampus, and to involve convergence of dentate granule cells on CA3 pyramidal cells, and NMDA receptors. This circuit forms part of a model neural system for the coordinated control of recognition learning, reinforcement learning, and motor learning, whose properties clarify how an animal can learn to acquire a delayed reward. Behavioral and neural data are summarized in support of each processing stage of the system. The relevant anatomical sites are in thalamus, neocortex, hippocampus, hypothalamus, amygdala, and cerebellum. Cerebellar influences on motor learning are distinguished from hippocampal influences on adaptive timing of reinforcement learning. The model simulates how damage to the hippocampal formation disrupts adaptive timing, eliminates attentional blocking, and causes symptoms of medial temporal amnesia. It suggests how normal acquisition of subcortical emotional conditioning can occur after cortical ablation, even though extinction of emotional conditioning is retarded by cortical ablation. The model simulates how increasing the duration of an unconditioned stimulus increases the amplitude of emotional conditioning, but does not change adaptive timing; and how an increase in the intensity of a conditioned stimulus "speeds up the clock", but an increase in the intensity of an unconditioned stimulus does not. Computer simulations of the model fit parametric conditioning data, including a Weber law property and an inverted U property. Both primary and secondary adaptively timed conditioning are simulated, as are data concerning conditioning using multiple interstimulus intervals (ISIs), gradually or abruptly changing ISis, partial reinforcement, and multiple stimuli that lead to time-averaging of responses. Neurobiologically testable predictions are made to facilitate further tests of the model.Air Force Office of Scientific Research (90-0175, 90-0128); Defense Advanced Research Projects Agency (90-0083); National Science Foundation (IRI-87-16960); Office of Naval Research (N00014-91-J-4100

Can Intellectual Processes in the Sciences Also Be Simulated? The Anticipation and Visualization of Possible Future States

Socio-cognitive action reproduces and changes both social and cognitive structures. The analytical distinction between these dimensions of structure provides us with richer models of scientific development. In this study, I assume that (i) social structures organize expectations into belief structures that can be attributed to individuals and communities; (ii) expectations are specified in scholarly literature; and (iii) intellectually the sciences (disciplines, specialties) tend to self-organize as systems of rationalized expectations. Whereas social organizations remain localized, academic writings can circulate, and expectations can be stabilized and globalized using symbolically generalized codes of communication. The intellectual restructuring, however, remains latent as a second-order dynamics that can be accessed by participants only reflexively. Yet, the emerging "horizons of meaning" provide feedback to the historically developing organizations by constraining the possible future states as boundary conditions. I propose to model these possible future states using incursive and hyper-incursive equations from the computation of anticipatory systems. Simulations of these equations enable us to visualize the couplings among the historical--i.e., recursive--progression of social structures along trajectories, the evolutionary--i.e., hyper-incursive--development of systems of expectations at the regime level, and the incursive instantiations of expectations in actions, organizations, and texts.Comment: accepted for publication in Scientometrics (June 2015

Consciousness CLEARS the Mind

A full understanding of consciouness requires that we identify the brain processes from which conscious experiences emerge. What are these processes, and what is their utility in supporting successful adaptive behaviors? Adaptive Resonance Theory (ART) predicted a functional link between processes of Consciousness, Learning, Expectation, Attention, Resonance, and Synchrony (CLEARS), includes the prediction that "all conscious states are resonant states." This connection clarifies how brain dynamics enable a behaving individual to autonomously adapt in real time to a rapidly changing world. The present article reviews theoretical considerations that predicted these functional links, how they work, and some of the rapidly growing body of behavioral and brain data that have provided support for these predictions. The article also summarizes ART models that predict functional roles for identified cells in laminar thalamocortical circuits, including the six layered neocortical circuits and their interactions with specific primary and higher-order specific thalamic nuclei and nonspecific nuclei. These prediction include explanations of how slow perceptual learning can occur more frequently in superficial cortical layers. ART traces these properties to the existence of intracortical feedback loops, and to reset mechanisms whereby thalamocortical mismatches use circuits such as the one from specific thalamic nuclei to nonspecific thalamic nuclei and then to layer 4 of neocortical areas via layers 1-to-5-to-6-to-4.National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624

Multifaceted companion devices: applying the new model of media attendance to smartphone usage

This study inspects the relationship between outcome expectations, habit strength, and smartphone usage by attempting to validate the new model of media attendance (NMMA) (LaRose and Eastin, 2004) , a social-cognitive theory of uses and gratifications. The fast adoption rate of smartphones, and their inherent characteristics as convergent, always-on, always-connected devices, warrant a closer look into user habitualization of this medium. Using a sample of 481 smartphone users selected from a larger panel, we were able to support the NMMA, although surprisingly no significant effect of habit strength on smartphone usage was found. While some uncertainties connected to the method are noted, this suggests a more complex reality, in which habitualization of a convergent media device does not necessarily implicate a significant rise in usage