Joining up health and bioinformatics: e-science meets e-health

CLEF (Co-operative Clinical e-Science Framework) is an MRC sponsored project in the e-Science programme that aims to establish methodologies and a technical infrastructure forthe next generation of integrated clinical and bioscience research. It is developing methodsfor managing and using pseudonymised repositories of the long-term patient histories whichcan be linked to genetic, genomic information or used to support patient care. CLEF concentrateson removing key barriers to managing such repositories ? ethical issues, informationcapture, integration of disparate sources into coherent ?chronicles? of events, userorientedmechanisms for querying and displaying the information, and compiling the requiredknowledge resources. This paper describes the overall information flow and technicalapproach designed to meet these aims within a Grid framework

Provenance-based trust for grid computing: Position Paper

Current evolutions of Internet technology such as Web Services, ebXML, peer-to-peer and Grid computing all point to the development of large-scale open networks of diverse computing systems interacting with one another to perform tasks. Grid systems (and Web Services) are exemplary in this respect and are perhaps some of the first large-scale open computing systems to see widespread use - making them an important testing ground for problems in trust management which are likely to arise. From this perspective, today's grid architectures suffer from limitations, such as lack of a mechanism to trace results and lack of infrastructure to build up trust networks. These are important concerns in open grids, in which "community resources" are owned and managed by multiple stakeholders, and are dynamically organised in virtual organisations. Provenance enables users to trace how a particular result has been arrived at by identifying the individual services and the aggregation of services that produced such a particular output. Against this background, we present a research agenda to design, conceive and implement an industrial-strength open provenance architecture for grid systems. We motivate its use with three complex grid applications, namely aerospace engineering, organ transplant management and bioinformatics. Industrial-strength provenance support includes a scalable and secure architecture, an open proposal for standardising the protocols and data structures, a set of tools for configuring and using the provenance architecture, an open source reference implementation, and a deployment and validation in industrial context. The provision of such facilities will enrich grid capabilities by including new functionalities required for solving complex problems such as provenance data to provide complete audit trails of process execution and third-party analysis and auditing. As a result, we anticipate that a larger uptake of grid technology is likely to occur, since unprecedented possibilities will be offered to users and will give them a competitive edge

Using semantic indexing to improve searching performance in web archives

The sheer volume of electronic documents being published on the Web can be overwhelming for users if the searching aspect is not properly addressed. This problem is particularly acute inside archives and repositories containing large collections of web resources or, more precisely, web pages and other web objects. Using the existing search capabilities in web archives, results can be compromised because of the size of data, content heterogeneity and changes in scientific terminologies and meanings. During the course of this research, we will explore whether semantic web technologies, particularly ontology-based annotation and retrieval, could improve precision in search results in multi-disciplinary web archives

Non-human Modelers:Challenges and Roadmap for Reusable Self-explanation

Increasingly, software acts as a “non-human modeler” (NHM), managing a model according to high-level goals rather than a predefined script. To foster adoption, we argue that we should treat these NHMs as members of the development team. In our GrandMDE talk, we discussed the importance of three areas: effective communication (self-explanation and problem-oriented configuration), selection, and process integration. In this extended version of the talk, we will expand on the self-explanation area, describing its background in more depth and outlining a research roadmap based on a basic case study