The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation

We generalize the SiZer of Chaudhuri and Marron (J. Amer. Statist. Assoc. 94 (1999) 807-823, Ann. Statist. 28 (2000) 408-428) for the detection of shape parameters of densities on the real line to the case of circular data. It turns out that only the wrapped Gaussian kernel gives a symmetric, strongly Lipschitz semi-group satisfying "circular" causality, that is, not introducing possibly artificial modes with increasing levels of smoothing. Some notable differences between Euclidean and circular scale space theory are highlighted. Based on this, we provide an asymptotic theory to make inference about the persistence of shape features. The resulting circular mode persistence diagram is applied to the analysis of early mechanically-induced differentiation in adult human stem cells from their actin-myosin filament structure. As a consequence, the circular SiZer based on the wrapped Gaussian kernel (WiZer) allows the verification at a controlled error level of the observation reported by Zemel et al. (Nat. Phys. 6 (2010) 468-473): Within early stem cell differentiation, polarizations of stem cells exhibit preferred directions in three different micro-environments.Comment: Published at http://dx.doi.org/10.3150/15-BEJ722 in the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Well-posedness of a nonlinear integro-differential problem and its rearranged formulation

We study the existence and uniqueness of solutions of a nonlinear integro-differential problem which we reformulate introducing the notion of the decreasing rearrangement of the solution. A dimensional reduction of the problem is obtained and a detailed analysis of the properties of the solutions of the model is provided. Finally, a fast numerical method is devised and implemented to show the performance of the model when typical image processing tasks such as filtering and segmentation are performed.Comment: Final version. To appear in Nolinear Analysis Real World Applications (2016

A network for multiscale image segmentation

Detecting edges of objects in their images is a basic problem in computational vision. The scale-space technique introduced by Witkin [11] provides means of using local and global reasoning in locating edges. This approach has a major drawback: it is difficult to obtain accurately the locations of the 'semantically meaningful' edges. We have refined the definition of scale-space, and introduced a class of algorithms for implementing it based on using anisotropic diffusion [9]. The algorithms involves simple, local operations replicated over the image making parallel hardware implementation feasible. In this paper we present the major ideas behind the use of scale space, and anisotropic diffusion for edge detection, we show that anisotropic diffusion can enhance edges, we suggest a network implementation of anisotropic diffusion, and provide design criteria for obtaining networks performing scale space, and edge detection. The results of a software implementation are shown