Uncovering spatial topology represented by rat hippocampal population neuronal codes

Hippocampal population codes play an important role in representation of spatial environment and spatial navigation. Uncovering the internal representation of hippocampal population codes will help understand neural mechanisms of the hippocampus. For instance, uncovering the patterns represented by rat hippocampus (CA1) pyramidal cells during periods of either navigation or sleep has been an active research topic over the past decades. However, previous approaches to analyze or decode firing patterns of population neurons all assume the knowledge of the place fields, which are estimated from training data a priori. The question still remains unclear how can we extract information from population neuronal responses either without a priori knowledge or in the presence of finite sampling constraint. Finding the answer to this question would leverage our ability to examine the population neuronal codes under different experimental conditions. Using rat hippocampus as a model system, we attempt to uncover the hidden “spatial topology” represented by the hippocampal population codes. We develop a hidden Markov model (HMM) and a variational Bayesian (VB) inference algorithm to achieve this computational goal, and we apply the analysis to extensive simulation and experimental data. Our empirical results show promising direction for discovering structural patterns of ensemble spike activity during periods of active navigation. This study would also provide useful insights for future exploratory data analysis of population neuronal codes during periods of sleep.National Institutes of Health (U.S.) (NIH Grant DP1-OD003646)National Institutes of Health (U.S.) (Grant MH061976

Uncovering temporal structure in hippocampal output patterns.

Place cell activity of hippocampal pyramidal cells has been described as the cognitive substrate of spatial memory. Replay is observed during hippocampal sharp-wave-ripple-associated population burst events (PBEs) and is critical for consolidation and recall-guided behaviors. PBE activity has historically been analyzed as a phenomenon subordinate to the place code. Here, we use hidden Markov models to study PBEs observed in rats during exploration of both linear mazes and open fields. We demonstrate that estimated models are consistent with a spatial map of the environment, and can even decode animals' positions during behavior. Moreover, we demonstrate the model can be used to identify hippocampal replay without recourse to the place code, using only PBE model congruence. These results suggest that downstream regions may rely on PBEs to provide a substrate for memory. Additionally, by forming models independent of animal behavior, we lay the groundwork for studies of non-spatial memory

Revealing ensemble state transition patterns in multi-electrode neuronal recordings using hidden Markov models

In order to harness the computational capacity of dissociated cultured neuronal networks, it is necessary to understand neuronal dynamics and connectivity on a mesoscopic scale. To this end, this paper uncovers dynamic spatiotemporal patterns emerging from electrically stimulated neuronal cultures using hidden Markov models (HMMs) to characterize multi-channel spike trains as a progression of patterns of underlying states of neuronal activity. However, experimentation aimed at optimal choice of parameters for such models is essential and results are reported in detail. Results derived from ensemble neuronal data revealed highly repeatable patterns of state transitions in the order of milliseconds in response to probing stimuli

Uncovering elements of style

This paper relates the style of 16th century Flemish paintings by Goossen van der Weyden (GvdW) to the style of preliminary sketches or underpaintings made prior to executing the painting. Van der Weyden made underpaintings in markedly different styles for reasons as yet not understood by art historians. The analysis presented here starts from a classification of the underpaintings into four distinct styles by experts in art history. Analysis of the painted surfaces by a combination of wavelet analysis, hidden Markov trees and boosting algorithms can distinguish the four underpainting styles with greater than 90% cross-validation accuracy. On a subsequent blind test this classifier provided insight into the hypothesis by art historians that different patches of the finished painting were executed by different hands

Analysis of Colored Pottery Decoration using Hidden Markov Model Directional Clustering Classification with Deep Learning

Colored pottery decoration is an important cultural artifact that carries significant imagery, symbols, and cultural connotations. This paper presented an in-depth analysis of colored pottery decoration by employing a novel approach, Hidden Markov Model Directional Clustering Classification (HMMDCC), combined with deep learning techniques. The evaluated data comprehensive dataset of colored pottery designs, representing different historical periods and cultural contexts. The imagery, symbols, and cultural connotations embedded in the designs are extracted through a combination of computer vision and image processing techniques. The HMMDCC model is then utilized to perform directional clustering, which identifies spatial relationships and patterns within the decoration elements. To enhance classification accuracy and capture intricate patterns, deep learning techniques are incorporated into the HMMDCC model. The deep learning model is trained on the dataset, enabling it to recognize and classify the imagery, symbols, and cultural connotations present in colored pottery decoration. The findings of this study shed light on the hidden meanings and cultural significance associated with colored pottery decoration. The application of the HMMDCC model with deep learning showcases its effectiveness in analyzing and interpreting complex visual data. The results contribute to a deeper understanding of the historical and cultural contexts in which colored pottery decoration emerged, providing valuable insights for archaeologists, historians, and art enthusiasts

Hierarchical relational models for document networks

We develop the relational topic model (RTM), a hierarchical model of both network structure and node attributes. We focus on document networks, where the attributes of each document are its words, that is, discrete observations taken from a fixed vocabulary. For each pair of documents, the RTM models their link as a binary random variable that is conditioned on their contents. The model can be used to summarize a network of documents, predict links between them, and predict words within them. We derive efficient inference and estimation algorithms based on variational methods that take advantage of sparsity and scale with the number of links. We evaluate the predictive performance of the RTM for large networks of scientific abstracts, web documents, and geographically tagged news.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS309 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org