Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).

BACKGROUND: The prognosis for young people diagnosed with diabetes during childhood remains poor and this is mainly related to the long-term risk of developing vascular complications.Microalbuminuria identifies subjects at risk for diabetic nephropathy (DN) and cardiovascular disease (CVD). It is often detected in adolescence but is rarely treated before the age of 18 years, as at the end of puberty albumin excretion may decline and in some subjects will return into the normal range. However, evidence indicates that subjects with both transient and persistent microalbuminuria have experienced renal damage during puberty and thus reno-protection to prevent long-term complications is warranted. In adults with diabetes and microalbuminuria, the use of angiotensin converting enzyme inhibitors (ACEI) and Statins is increasing, and in order to determine whether these agents are of value in the adolescent population a large randomized controlled clinical trial is needed. METHODS/DESIGN: The Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) is a multi-center, randomized, double-blind, placebo-controlled trial of ACEI and Statin therapy in adolescents with type 1 diabetes. 500 high-risk adolescents, defined on the basis of their albumin excretion, are randomized to receive either ACEI (Quinapril) or Statins (Atorvastatin) or combination therapy or placebo for 3-4 years. There will also be a parallel open observational study, based on the follow-up of 400 low-risk non-randomized adolescents. The major endpoint of the study is the change in albumin excretion; secondary endpoints include markers of CVD, renal function, retinopathy, quality of life combined with assessment of compliance and potential health economic benefits. DISCUSSION: AdDIT will provide important data on the potential renal and cardiovascular protective effects of ACEI and Statins in high-risk adolescents. Long-term follow-up of the randomized subjects will provide direct evidence of disease outcomes, in addition to the data on early surrogate measures of DN and CVD. Follow-up of non-randomized low-risk subjects will determine the potential impact of intervention on DN and CVD. AdDIT will help to determine whether, in addition to encouraging young people to achieve good glycaemic control, pharmacological cardio-renal protection should also be implemented. EUDRACT NUMBER: 2007-001039-72 TRIAL REGISTRATION NUMBER: ISRCTN91419926.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Type 1 diabetes

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care

An Infrared Comparison of Type-1 and Type-2 Quasars

We model the optical to far-infrared SEDs of a sample of six type-1 and six type-2 quasars selected in the mid-infrared. The objects in our sample are matched in mid-IR luminosity and selected based on their Spitzer IRAC colors. We obtained new targeted Spitzer IRS and MIPS observations and used archival photometry to examine the optical to far-IR SEDs. We investigate whether the observed differences between samples are consistent with orientation-based unification schemes. The type-1 objects show significant emission at 3 micron. They do not show strong PAH emission and have less far-IR emission on average when compared to the type-2 objects. The SEDs of the type-2 objects show a wide assortment of silicate features, ranging from weak emission to deep silicate absorption. Some also show strong PAH features. In comparison, silicate is only seen in emission in the type-1 objects. This is consistent with some of the type-2s being reddened by a foreground screen of cooler dust, perhaps in the host galaxy itself. We investigate the AGN contribution to the far-IR emission and find it to be significant. We also estimate the star formation rate for each of the objects by integrating the modeled far-IR flux and compare this with the SFR found from PAH emission. We find the type-2 quasars have a higher average SFR than the type-1 quasars based on both methods, though this could be due to differences in bolometric luminosities of the objects. While we find pronounced differences between the two types of objects, none of them are inconsistent with orientation-based unification schemes.Comment: Accepted for publication in Ap

SO_0(1,d+1) Racah coefficients: Type I representations

We use AdS/CFT inspired methods to study the Racah coefficients for type I representations of the Lorentz group SO_0(1,d+1) with d>1. For such representations (a multiple of) the Racah coefficient can be represented as an integral of a product of 6 bulk-to-bulk propagators over 4 copies of the hyperbolic space H_{d+1}. To compute the integrals we represent the bulk-to-bulk propagators in terms of bulk-to-boundary ones. The bulk integrals can be computed explicitly, and the boundary integrations are carried out by introducing Feynman parameters. The final result is an integral representation of the Racah coefficient given by 4 Barnes-Mellin type integrals.Comment: 20 pages, 1 figure. v2: Case d=1 corrected, case d>1 clarifie

Type 1 diabetes in children

Many children are not diagnosed early enough. Nicky Kime highlights the symptoms and importance of an accurate early diagnosis

Cluster algebras of type A2(1)A_2^{(1)}

In this paper we study cluster algebras \myAA of type $A_2^{(1)}$. We solve the recurrence relations among the cluster variables (which form a T--system of type $A_2^{(1)}$). We solve the recurrence relations among the coefficients of \myAA (which form a Y--system of type $A_2^{(1)}$). In \myAA there is a natural notion of positivity. We find linear bases \BB of \myAA such that positive linear combinations of elements of \BB coincide with the cone of positive elements. We call these bases \emph{atomic bases} of \myAA. These are the analogue of the "canonical bases" found by Sherman and Zelevinsky in type $A_{1}^{(1)}$. Every atomic basis consists of cluster monomials together with extra elements. We provide explicit expressions for the elements of such bases in every cluster. We prove that the elements of \BB are parameterized by \ZZ^3 via their $\mathbf{g}$--vectors in every cluster. We prove that the denominator vector map in every acyclic seed of \myAA restricts to a bijection between \BB and \ZZ^3. In particular this gives an explicit algorithm to determine the "virtual" canonical decomposition of every element of the root lattice of type $A_2^{(1)}$. We find explicit recurrence relations to express every element of \myAA as linear combinations of elements of \BB.Comment: Latex, 40 pages; Published online in Algebras and Representation Theory, springer, 201

Cell Therapy for Type 1 Diabetes

Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher PD

Type Dn(1)D_n^{(1)} rigged configuration bijection

We establish a bijection between the set of rigged configurations and the set of tensor products of Kirillov--Reshetikhin crystals of type $D^{(1)}_n$ in full generality. We prove the invariance of rigged configurations under the action of the combinatorial $R$-matrix on tensor products and show that the bijection preserves certain statistics (cocharge and energy). As a result, we establish the fermionic formula for type $D_n^{(1)}$. In addition, we establish that the bijection is a classical crystal isomorphism.Comment: 54 page

D=4, N=1, Type IIA Orientifolds

We study D=4, N=1, type IIA orientifold with orbifold group $Z_N$ and $Z_N \times Z_M$. We calculate one-loop vacuum amplitudes for Klein bottle, cylinder and Mobius strip and extract the tadpole divergences. We find that the tadpole cancellation conditions thus obtained are satisfied by the $Z_4$, $Z_8$, $Z'_8$, $Z'_{12}$ orientifolds while there is no solution for $Z_3$, $Z_7$, $Z_6$, $Z'_6$, $Z_{12}$. The $Z_4 \times Z_4$ type IIA orientifold is also constructed by introducing four different configurations of 6-branes. We argue about perturbative versus non-perturbative orientifold vacua under T- duality between the type IIA and the type IIB $Z_N$ orientifolds in four dimensions.Comment: 32 pages, LaTe