Design of Experiments for Screening

The aim of this paper is to review methods of designing screening experiments, ranging from designs originally developed for physical experiments to those especially tailored to experiments on numerical models. The strengths and weaknesses of the various designs for screening variables in numerical models are discussed. First, classes of factorial designs for experiments to estimate main effects and interactions through a linear statistical model are described, specifically regular and nonregular fractional factorial designs, supersaturated designs and systematic fractional replicate designs. Generic issues of aliasing, bias and cancellation of factorial effects are discussed. Second, group screening experiments are considered including factorial group screening and sequential bifurcation. Third, random sampling plans are discussed including Latin hypercube sampling and sampling plans to estimate elementary effects. Fourth, a variety of modelling methods commonly employed with screening designs are briefly described. Finally, a novel study demonstrates six screening methods on two frequently-used exemplars, and their performances are compared

Screening Experiments for Simulation: A Review

This article reviews so-called screening in simulation; i.e., it examines the search for the really important factors in experiments with simulation models that have very many factors (or inputs). The article focuses on a most efficient and effec- tive screening method, namely Sequential Bifurcation. It ends with a discussion of possible topics for future research, and forty references for further study.Screening;Metamodel;Response Surface;Design

A fully automatic CAD-CTC system based on curvature analysis for standard and low-dose CT data

Computed tomography colonography (CTC) is a rapidly evolving noninvasive medical investigation that is viewed by radiologists as a potential screening technique for the detection of colorectal polyps. Due to the technical advances in CT system design, the volume of data required to be processed by radiologists has increased significantly, and as a consequence the manual analysis of this information has become an increasingly time consuming process whose results can be affected by inter- and intrauser variability. The aim of this paper is to detail the implementation of a fully integrated CAD-CTC system that is able to robustly identify the clinically significant polyps in the CT data. The CAD-CTC system described in this paper is a multistage implementation whose main system components are: 1) automatic colon segmentation; 2) candidate surface extraction; 3) feature extraction; and 4) classification. Our CAD-CTC system performs at 100% sensitivity for polyps larger than 10 mm, 92% sensitivity for polyps in the range 5 to 10 mm, and 57.14% sensitivity for polyps smaller than 5 mm with an average of 3.38 false positives per dataset. The developed system has been evaluated on synthetic and real patient CT data acquired with standard and low-dose radiation levels

Sensitivity analysis and related analysis: A survey of statistical techniques

This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type of analysis be applied; which statistical techniques may then be used? This paper distinguishes the following five stages in the analysis of a simulation model. 1) Validation: the availability of data on the real system determines which type of statistical technique to use for validation. 2) Screening: in the simulation's pilot phase the really important inputs can be identified through a novel technique, called sequential bifurcation, which uses aggregation and sequential experimentation. 3) Sensitivity analysis: the really important inputs should be This approach with its five stages implies that sensitivity analysis should precede uncertainty analysis. This paper briefly discusses several case studies for each phase.Experimental Design;Statistical Methods;Regression Analysis;Risk Analysis;Least Squares;Sensitivity Analysis;Optimization;Perturbation;statistics

Identifying the important factors in simulation models with many factors

Simulation models may have many parameters and input variables (together called factors), while only a few factors are really important (parsimony principle). For such models this paper presents an effective and efficient screening technique to identify and estimate those important factors. The technique extends the classical binary search technique to situations with more than a single important factor. The technique uses a low-order polynomial approximation to the input/output behavior of the simulation model. This approximation may account for interactions among factors. The technique is demonstrated by applying it to a complicated ecological simulation that models the increase of temperatures worldwide.Simulation Models;econometrics

AI for public health: Self-screening for eye diseases

A software-based visual-field testing (perimetry) system is described which incorporates several AI components, including machine learning, an intelligent user interface and pattern discovery. This system has been successfully used for self-screening in several different public environment