3 research outputs found
'A net for everyone': fully personalized and unsupervised neural networks trained with longitudinal data from a single patient
With the rise in importance of personalized medicine, we trained personalized
neural networks to detect tumor progression in longitudinal datasets. The model
was evaluated on two datasets with a total of 64 scans from 32 patients
diagnosed with glioblastoma multiforme (GBM). Contrast-enhanced T1w sequences
of brain magnetic resonance imaging (MRI) images were used in this study. For
each patient, we trained their own neural network using just two images from
different timepoints. Our approach uses a Wasserstein-GAN (generative
adversarial network), an unsupervised network architecture, to map the
differences between the two images. Using this map, the change in tumor volume
can be evaluated. Due to the combination of data augmentation and the network
architecture, co-registration of the two images is not needed. Furthermore, we
do not rely on any additional training data, (manual) annotations or
pre-training neural networks. The model received an AUC-score of 0.87 for tumor
change. We also introduced a modified RANO criteria, for which an accuracy of
66% can be achieved. We show that using data from just one patient can be used
to train deep neural networks to monitor tumor change