H2O: An Autonomic, Resource-Aware Distributed Database System

This paper presents the design of an autonomic, resource-aware distributed database which enables data to be backed up and shared without complex manual administration. The database, H2O, is designed to make use of unused resources on workstation machines. Creating and maintaining highly-available, replicated database systems can be difficult for untrained users, and costly for IT departments. H2O reduces the need for manual administration by autonomically replicating data and load-balancing across machines in an enterprise. Provisioning hardware to run a database system can be unnecessarily costly as most organizations already possess large quantities of idle resources in workstation machines. H2O is designed to utilize this unused capacity by using resource availability information to place data and plan queries over workstation machines that are already being used for other tasks. This paper discusses the requirements for such a system and presents the design and implementation of H2O.Comment: Presented at SICSA PhD Conference 2010 (http://www.sicsaconf.org/

Fundamental Principles in Bacterial Physiology - History, Recent progress, and the Future with Focus on Cell Size Control: A Review

Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts. In the first part (Sections 1 to 3), we review the first `golden era' of bacterial physiology from the 1940s to early 1970s and provide a complete list of major references from that period. In the second part (Sections 4 to 7), we explain how the pioneering work from the first golden era has influenced various rediscoveries of general quantitative principles and significant further development in modern bacterial physiology. Specifically, Section 4 presents the history and current progress of the `adder' principle of cell size homeostasis. Section 5 discusses the implications of coarse-graining the cellular protein composition, and how the coarse-grained proteome `sectors' re-balance under different growth conditions. Section 6 focuses on physiological invariants, and explains how they are the key to understanding the coordination between growth and the cell cycle underlying cell size control in steady-state growth. Section 7 overviews how the temporal organization of all the internal processes enables balanced growth. In the final Section 8, we conclude by discussing the remaining challenges for the future in the field.Comment: Published in Reports on Progress in Physics. (https://doi.org/10.1088/1361-6633/aaa628) 96 pages, 48 figures, 7 boxes, 715 reference