Separation Framework: An Enabler for Cooperative and D2D Communication for Future 5G Networks

Soaring capacity and coverage demands dictate that future cellular networks need to soon migrate towards ultra-dense networks. However, network densification comes with a host of challenges that include compromised energy efficiency, complex interference management, cumbersome mobility management, burdensome signaling overheads and higher backhaul costs. Interestingly, most of the problems, that beleaguer network densification, stem from legacy networks' one common feature i.e., tight coupling between the control and data planes regardless of their degree of heterogeneity and cell density. Consequently, in wake of 5G, control and data planes separation architecture (SARC) has recently been conceived as a promising paradigm that has potential to address most of aforementioned challenges. In this article, we review various proposals that have been presented in literature so far to enable SARC. More specifically, we analyze how and to what degree various SARC proposals address the four main challenges in network densification namely: energy efficiency, system level capacity maximization, interference management and mobility management. We then focus on two salient features of future cellular networks that have not yet been adapted in legacy networks at wide scale and thus remain a hallmark of 5G, i.e., coordinated multipoint (CoMP), and device-to-device (D2D) communications. After providing necessary background on CoMP and D2D, we analyze how SARC can particularly act as a major enabler for CoMP and D2D in context of 5G. This article thus serves as both a tutorial as well as an up to date survey on SARC, CoMP and D2D. Most importantly, the article provides an extensive outlook of challenges and opportunities that lie at the crossroads of these three mutually entangled emerging technologies.Comment: 28 pages, 11 figures, IEEE Communications Surveys & Tutorials 201

Energy Efficiency Analysis of Heterogeneous Cache-enabled 5G Hyper Cellular Networks

The emerging 5G wireless networks will pose extreme requirements such as high throughput and low latency. Caching as a promising technology can effectively decrease latency and provide customized services based on group users behaviour (GUB). In this paper, we carry out the energy efficiency analysis in the cache-enabled hyper cellular networks (HCNs), where the macro cells and small cells (SCs) are deployed heterogeneously with the control and user plane (C/U) split. Benefiting from the assistance of macro cells, a novel access scheme is proposed according to both user interest and fairness of service, where the SCs can turn into semi- sleep mode. Expressions of coverage probability, throughput and energy efficiency (EE) are derived analytically as the functions of key parameters, including the cache ability, search radius and backhaul limitation. Numerical results show that the proposed scheme in HCNs can increase the network coverage probability by more than 200% compared with the single- tier networks. The network EE can be improved by 54% than the nearest access scheme, with larger research radius and higher SC cache capacity under lower traffic load. Our performance study provides insights into the efficient use of cache in the 5G software defined networking (SDN)

Hybrid Spectrum Sharing in mmWave Cellular Networks

While spectrum at millimeter wave (mmWave) frequencies is less scarce than at traditional frequencies below 6 GHz, still it is not unlimited, in particular if we consider the requirements from other services using the same band and the need to license mmWave bands to multiple mobile operators. Therefore, an efficient spectrum access scheme is critical to harvest the maximum benefit from emerging mmWave technologies. In this paper, we introduce a new hybrid spectrum access scheme for mmWave networks, where data is aggregated through two mmWave carriers with different characteristics. In particular, we consider the case of a hybrid spectrum scheme between a mmWave band with exclusive access and a mmWave band where spectrum is pooled between multiple operators. To the best of our knowledge, this is the first study proposing hybrid spectrum access for mmWave networks and providing a quantitative assessment of its benefits. Our results show that this approach provides major advantages with respect to traditional fully licensed or fully unlicensed spectrum access schemes, though further work is needed to achieve a more complete understanding of both technical and non technical implications

A new targeted CFTR mutation panel based on next-generation sequencing technology

Searching for mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) is a key step in the diagnosis of and neonatal and carrier screening for cystic fibrosis (CF), and it has implications for prognosis and personalized therapy. The large number of mutations and genetic and phenotypic variability make this search a complex task. Herein, we developed, validated, and tested a laboratory assay for an extended search for mutations in CFTR using a next-generation sequencing based method, with a panel of 188 CFTR mutations customized for the Italian population. Overall, 1426 dried blood spots from neonatal screening, 402 genomic DNA samples from various origins, and 1138 genomic DNA samples from patients with CF were analyzed. The assay showed excellent analytical and diagnostic operative characteristics. We identified and experimentally validated 159 (of 188) CFTR mutations. The assay achieved detection rates of 95.0% and 95.6% in two large-scale case series of CF patients from central and northern Italy, respectively. These detection rates are among the highest reported so far with a genetic test for CF based on a mutation panel. This assay appears to be well suited for diagnostics, neonatal and carrier screening, and assisted reproduction, and it represents a considerable advantage in CF genetic counseling