Recent Advances in the Development of Biomimetic Materials

: In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a "bottom-up" artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics

Biomimetics design for tribological applications

Biomimetics, biomimicry and bionics are synonyms for the scientific discipline of creating new structures inspired by nature. Biomimetics systematically analyses the evolutionary processes of living organisms, their structural relationships, the characteristics of natural materials and it studies how this knowledge can be used to create the optimal products and new sustainable materials. In the past decade, the biomimetics has received an incentive for the development by the technology modernization, and above all, by making it possible to study the micro-and nanolevels of biological structures. On the other hand, the miniaturization of technological devices has increased the need to understand the tribological phenomena on micro-and nanolevel, where is a huge potential for technological innovation. The integration of advanced research methods made it possible to discover new aspects in the structure and properties of biological materials and transfer that knowledge into new concepts or products. State-of-the-art of biomimetics progress is discussed, as well as, its goals and the potential to simultaneously achieve the financial and ecological contribution by realization of bio-inspired concepts. An overview of biomimetic researches is also provided, with special emphasis on the possibility of their tribological applications. The characteristic examples have been presented and those examples show how the structural and mechanical properties of the material were used as the basis for developing new creative solutions to solve the problem of friction in engineering applications

Biomimetics design for tribological applications

Biomimetics, biomimicry and bionics are synonyms for the scientific discipline of creating new structures inspired by nature. Biomimetics systematically analyses the evolutionary processes of living organisms, their structural relationships, the characteristics of natural materials and it studies how this knowledge can be used to create the optimal products and new sustainable materials. In the past decade, the biomimetics has received an incentive for the development by the technology modernization, and above all, by making it possible to study the micro-and nanolevels of biological structures. On the other hand, the miniaturization of technological devices has increased the need to understand the tribological phenomena on micro-and nanolevel, where is a huge potential for technological innovation. The integration of advanced research methods made it possible to discover new aspects in the structure and properties of biological materials and transfer that knowledge into new concepts or products. State-of-the-art of biomimetics progress is discussed, as well as, its goals and the potential to simultaneously achieve the financial and ecological contribution by realization of bio-inspired concepts. An overview of biomimetic researches is also provided, with special emphasis on the possibility of their tribological applications. The characteristic examples have been presented and those examples show how the structural and mechanical properties of the material were used as the basis for developing new creative solutions to solve the problem of friction in engineering applications

Biomimicking Extracellular Vesicles with Fully Artificial Ones: A Rational Design of EV-BIOMIMETICS toward Effective Theranostic Tools in Nanomedicine

Extracellular Vesicles (EVs) are the protagonists in cell communication and membrane trafficking, being responsible for the delivery of innumerable biomolecules and signaling moieties. At the moment, they are of paramount interest to researchers, as they naturally show incredibly high efficiency and specificity in delivering their cargo. For these reasons, EVs are employed or inspire the development of nanosized therapeutic delivery systems. In this Perspective, we propose an innovative strategy for the rational design of EV-mimicking vesicles (EV-biomimetics) for theranostic scopes. We first report on the current state-of-the-art use of EVs and their byproducts, such as surface-engineered EVs and EV-hybrids, having an artificial cargo (drug molecule, genetic content, nanoparticles, or dye incorporated in their lumen). Thereafter, we report on the new emerging field of EV-mimicking vesicles for theranostic scopes. We introduce an approach to prepare new, fully artificial EV-biomimetics, with particular attention to maintaining the natural reference lipidic composition. We overview those studies investigating natural EV membranes and the possible strategies to identify key proteins involved in site-selective natural homing, typical of EVs, and their cargo transfer to recipient cells. We propose the use also of molecular simulations, in particular of machine learning models, to approach the problem of lipid organization and self-assembly in natural EVs. We also discuss the beneficial feedback that could emerge combining the experimental tests with atomistic and molecular simulations when designing an EV-biomimetics lipid bilayer. The expectations from both research and industrial fields on fully artificial EV-biomimetics, having the same key functions of natural ones plus new diagnostic or therapeutic functions, could be enormous, as they can greatly expand the nanomedicine applications and guarantee on-demand and scalable production, off-the-shelf storage, high reproducibility of morphological and functional properties, and compliance with regulatory standards

The application of BIM tools to explore the dynamic characteristics of smart materials in a contemporary Shanashil building design element

Traditional architecture is known for its crafted facade features that respond to environmental, social and cultural requirements. Contemporary architecture produced façade features that attempted to enhance local design identity and local culture. Despite the advantages of modern technology, architectural elements have difficulties in fulfilling the idea of sustainable elegance that once traditional elements provided. This problem calls for an interdisciplinary design approach to deliver sustainable design solutions that positively adapt to the surrounding environment as well as maintain the state of elegance in design. With this in mind, the research aims to explore the role of new glass technologies to improve the performance and at the same time maintain the design value of traditional façade element “shanashil” in Baghdadi buildings. This research utilises BIM tools and uses smart materials to restore the lost value in design, which mimics the dynamic characteristics observed in nature, inspired by biomimetics strategies. Such qualities are found in the characteristics of smart dynamic glazing material particularly in the switchable, reversible properties of transparency and coloration efficiency. The material characteristics are attached to a 3D digital prototype to visualise the difference between dynamic and static properties through the use of technology tools Revit plugin and smart glazing virtual reality prototype. This research concludes that the dynamic characteristics of smart glazing materials are effective in delivering a multifunctional design quality to collectively blend in harmony with the surrounding environment

Trade-offs in Computer-aided Biomimetics

Biomimetics, the application of mechanisms observed in nature to inform technical solutions, is inherently cross-disciplinary. For the most part, however, practitioners are only expert in one domain, e.g., engineering. Being a layman in the other domain, biology, can make it hard and time-consuming to find and understand relevant information. Computer-Aided Biomimetics (CAB) involves the development of computational tools to overcome this domain-expertise mismatch. Finding a bridge between engineering and biology has been challenging. Although a plethora of methodological approaches have been proposed to bridge the engineering and biology domains, Biomimetics remains adventitious and research intensive. We give an overview of previous research efforts in CAB and motivate our approach that revolves around the resolution of biological trade-offs. This is a unique approach, as previous work has always aimed to extract engineering functions from biological texts. We describe our novel CAB system that extracts trade-offs, a within-domain concept to indicate a dialectical relation between two or more biological traits. We provide a description of our dataset for the extraction of trade-offs from biology research papers, as well as our state-of-the-art Relation Extraction system. The dataset consists of over 1.5k sentences taken from biology research papers, describing a trade-off or similar high-level relation between two or more concepts. Furthermore, we provide an in-depth analysis of the information extracted by our CAB system from a corpus of 10k biology research papers. We show in a qualitative analysis that our system extracts key concepts and relations from biology research papers that are relevant to Biomimetics. Unique to our approach is that our system makes it feasible to collect a comprehensive list of the system parameters and solution principles used in biology. This enables statistical analysis, such as finding the distribution of fundamental principles among the resolution of various trade-offs. Notably, the solutions to trade-offs differ little over various hierarchical levels of biology. This makes our finding relevant to any research that aims to find desired, but underutilized, properties observed in nature

Nature as paradigm for sustainability in the textile and apparel industry

Imagine if clothing of the future would adapt, grow, self repair and change appearance. The relationship between wearer and garment would be that of symbiosis enabled by developments in material science that produce textiles able to imitate functionalities of living organisms rather than just the properties of natural fibres. We can expect clothing of the future to host an array of new properties that may interact or integrate with the body, self maintain, reproduce and self assemble to accommodate changes in our activity and environment. Materials and structures in nature already demonstrate these functions and can indicate ways of transferring the technology into clothing. Biomimetics can operate as a platform to accommodate these future requirements and provide a new perspective in the design and assembly of clothing systems

Biomimetic spatial and temporal (4D) design and fabrication

We imagine the built environment of the future as a ‘bio-hybrid machine for living in’ that will sense and react to activities within the space in order to provide experiences and services that will elevate quality of life while coexisting seamlessly with humans and the natural environment. The study of Hierarchical design in biological materials has the potential to alter the way designers/ engineers/ crafts-men of the future engage with materials in order to realise such visions. We are ex-ploring this design approach using digital manufacturing technologies such as jac-quard weaving and 3D printing