Towards Automatic Evaluation of Health-Related CQA Data

The paper reports on evaluation of Russian community question answering (CQA) data in health domain. About 1,500 question-answer pairs were manually evaluated by medical professionals, in addition automatic evaluation based on reference disease-medicine pairs was performed. Although the results of the manual and automatic evaluation do not fully match, we find the method still promising and propose several improvements. Automatic processing can be used to dynamically monitor the quality of the CQA content and to compare different data sources. Moreover, the approach can be useful for symptomatic surveillance and health education campaigns.This work is partially supported by the Russian Foundation for Basic Research, project #14-07-00589 “Data Analysis and User Modelling in Narrow-Domain Social Media”. We also thank assessors who volunteered for the evaluation and Mail.Ru for granting us access to the data

Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies

© 2019 American Chemical Society.The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. Therefore, it is not surprising that permeability of many different compounds has been measured through several in vitro and in vivo techniques. Moreover, many different in silico approaches have been used to identify the correlation between the structure of the permeants and their permeability, to reproduce the skin behavior, and to predict the ability of specific chemicals to permeate this barrier. A significant number of issues, like interlaboratory variability, experimental conditions, data set building rationales, and skin site of origin and hydration, still prevent us from obtaining a definitive predictive skin permeability model. This review wants to show the main advances and the principal approaches in computational methods used to predict this property, to enlighten the main issues that have arisen, and to address the challenges to develop in future research.Peer reviewedFinal Accepted Versio