Comparison of response surface methodology and the Nelder and Mead simplex method for optimization in microsimulation models

Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface Methodology and the Nelder and Mead Simplex Method for optimization of microsimulation models. To this end, we tested several automated versions of both methods on a small microsimulation model, as well as on a standard set of test functions. With respect to accuracy, Response Surface Methodology performed better in case of optimization of the microsimulation model, whereas the results for the test functions were rather variable. The Nelder and Mead Simplex Method performed more efficiently than Response Surface Methodology, both for the microsimulation model and the test functions.health;simulation;optimization

OPTIMIZING COMPLEX BIOECONOMIC SIMULATIONS USING AN EFFICIENT SEARCH HEURISTIC

For simulation to be truly useful for investigating many problems in agricultural economics, non-simplifying optimization techniques need to be employed. General methods for simulation optimization that do not inhibit system characterization or analysis are available, and they would appear to provide much of the mathematical and optimizing rigor demanded by economists. This paper describes the theory and algorithm of a robust and efficient simulation optimization approach, the Complex Method. An example of implementing the algorithm is illustrated using a pest management problem.simulation, optimization, Complex Method, hill-climbing, Research Methods/ Statistical Methods,

Comparison of response surface methodology and the Nelder and Mead simplex method for optimization in microsimulation models

Microsimulation models are increasingly used in the evaluation of cancer screening. Latent parameters of such models can be estimated by optimization of the goodness-of-fit. We compared the efficiency and accuracy of the Response Surface Methodology and the Nelder and Mead Simplex Method for optimization of microsimulation models. To this end, we tested several automated versions of both methods on a small microsimulation model, as well as on a standard set of test functions. With respect to accuracy, Response Surface Methodology performed better in case of optimization of the microsimulation model, whereas the results for the test functions were rather variable. The Nelder and Mead Simplex Method performed more efficiently than Response Surface Methodology, both for the microsimulation model and the test functions

Testing Strategies for Simulation Optimization

Testing Strategies for Simulation Optimizatio